| 1 | Mon Nov 4 | vs E Texas A&M | W89-67 | 1-0 | 1.000 | - | B1G+ | Carver-Hawkeye Arena · Iowa City, IA |
| 2 | Thu Nov 7 | vsSouthern | W89-74 | 2-0 | 1.000 | - | B1G+ | Carver-Hawkeye Arena · Iowa City, IA |
| 3 | Tue Nov 12 | vsSouth Dakota | W96-77 | 3-0 | 1.000 | - | BTN | Carver-Hawkeye Arena · Iowa City, IA |
| 4 | Fri Nov 15 | vsWashington St | W76-66 | 4-0 | 1.000 | - | BTN | Scotiabank Saddledome · Calgary, Alberta |
| 5 | Tue Nov 19 | vsRider | W83-58 | 5-0 | 1.000 | - | B1G+ | Carver-Hawkeye Arena · Iowa City, IA |
| 6 | Fri Nov 22 | vsUtah State | L69-77 | 5-1 | .833 | - | BTN | T-Mobile Center · Kansas City, MOS |
| 7 | Tue Nov 26 | vsSC Upstate | W110-77 | 6-1 | .857 | - | BTN | Carver-Hawkeye Arena · Iowa City, IA |
| 8 | Tue Dec 3 | vsNorthwestern | W80-79 | 7-1 | .875 | - | Peacock | Carver-Hawkeye Arena · Iowa City, IA |
| 9 | Sat Dec 7 | atMichigan | L83-85 | 7-2 | .778 | - | FS1 | Crisler Center · Ann Arbor, MI |
| 10 | Thu Dec 12 | vs3Iowa State | L80-89 | 7-3 | .700 | - | FS1 | Carver-Hawkeye Arena · Iowa City, IA |
| 11 | Sun Dec 15 | vsNew Orleans | W104-57 | 8-3 | .727 | - | BTN | Carver-Hawkeye Arena · Iowa City, IA |
| 12 | Sat Dec 21 | vsUtah | W95-88 | 9-3 | .750 | - | BTN | Carver-Hawkeye Arena · Iowa City, IA |
| 13 | Mon Dec 30 | vsNew Hampshire | W112-70 | 10-3 | .769 | - | BTN | Carver-Hawkeye Arena · Iowa City, IA |
| 14 | Fri Jan 3 | atWisconsin | L85-116 | 10-4 | .714 | - | FS1 | Kohl Center · Madison, WI |
| 15 | Tue Jan 7 | vsNebraska | W97-87 (OT) | 11-4 | .733 | - | Peacock | Carver-Hawkeye Arena · Iowa City, IA |
| 16 | Sat Jan 11 | vsIndiana | W85-60 | 12-4 | .750 | - | FOX | Carver-Hawkeye Arena · Iowa City, IA |
| 17 | Tue Jan 14 | atUSC | L89-99 | 12-5 | .706 | - | FS1 | Galen Center · Los Angeles, CA |
| 18 | Fri Jan 17 | atUCLA | L70-94 | 12-6 | .667 | - | FS1 | Pauley Pavilion · Los Angeles, CA |
| 19 | Tue Jan 21 | vsMinnesota | L67-72 | 12-7 | .632 | - | BTN | Carver-Hawkeye Arena · Iowa City, IA |
| 20 | Fri Jan 24 | vsPenn State | W76-75 | 13-7 | .650 | - | FS1 | Carver-Hawkeye Arena · Iowa City, IA |
| 21 | Mon Jan 27 | atOhio State | L65-82 | 13-8 | .619 | - | FS1 | Value City Arena · Columbus, OH |
| 22 | Tue Feb 4 | vs7Purdue | L81-90 | 13-9 | .591 | - | Peacock | Carver-Hawkeye Arena · Iowa City, IA |
| 23 | Sat Feb 8 | vs21Wisconsin | L63-74 | 13-10 | .565 | - | NBC | Carver-Hawkeye Arena · Iowa City, IA |
| 24 | Wed Feb 12 | atRutgers | W84-73 | 14-10 | .583 | - | BTN | Jersey Mike’s Arena · Piscataway, NJ |
| 25 | Sun Feb 16 | at25Maryland | L75-101 | 14-11 | .560 | - | FS1 | XFINITY Center · College Park, MD |
| 26 | Wed Feb 19 | vsOregon | L78-80 | 14-12 | .538 | - | BTN | Carver-Hawkeye Arena · Iowa City, IA |
| 27 | Sat Feb 22 | vsWashington | W85-79 | 15-12 | .556 | - | FS1 | Carver-Hawkeye Arena · Iowa City, IA |
| 28 | Tue Feb 25 | atIllinois | L61-81 | 15-13 | .536 | - | FS1 | State Farm Center · Champaign, IL |
| 29 | Fri Feb 28 | atNorthwestern | L57-68 | 15-14 | .517 | - | FS1 | Welsh-Ryan Arena · Evanston, IL |
| 30 | Thu Mar 6 | vs8Michigan St | L84-91 | 15-15 | .500 | - | FS1 | Carver-Hawkeye Arena · Iowa City, IA |
| 31 | Sun Mar 9 | atNebraska | W83-68 | 16-15 | .516 | - | FOX | Pinnacle Bank Arena · Lincoln, NE |
| 32 | Wed Mar 12 | atOhio State | W77-70 | 17-15 | .531 | - | Peacock | Value City Arena · Columbus, OH |
| 33 | Thu Mar 13 | at24Illinois | L94-106 | 17-16 | .515 | - | BTN | State Farm Center · Champaign, IL |
