| 1 | Mon Nov 3 | vs Mercyhurst | W70-47 | 1-0 | 1.000 | - | B1G+ | Welsh-Ryan Arena · Evanston, IL |
| 2 | Fri Nov 7 | vsBoston Univ | W76-52 | 2-0 | 1.000 | - | Peacock | Welsh-Ryan Arena · Evanston, IL |
| 3 | Mon Nov 10 | vsCleveland St | W110-63 | 3-0 | 1.000 | - | BTN | Welsh-Ryan Arena · Evanston, IL |
| 4 | Fri Nov 14 | atDePaul | W81-79 | 4-0 | 1.000 | - | truTV | Wintrust Arena · Chicago, IL |
| 5 | Fri Nov 21 | atVirginia | L78-83 | 4-1 | .800 | - | CBSSN | John Paul Jones Arena · Charlottesville, VA |
| 6 | Sun Nov 23 | vsSouth Carolina | W79-77 | 5-1 | .833 | - | CBSSN | Welsh-Ryan Arena · Evanston, IL |
| 7 | Thu Nov 27 | vsOklahoma St | L81-86 | 5-2 | .714 | - | BTN | Welsh-Ryan Arena · Evanston, IL |
| 8 | Wed Dec 3 | atWisconsin | L73-85 | 5-3 | .625 | - | BTN | Kohl Center · Madison, WI |
| 9 | Sat Dec 6 | vsOhio State | L82-86 | 5-4 | .556 | - | BTN | Welsh-Ryan Arena · Evanston, IL |
| 10 | Sat Dec 13 | vsJackson St | W93-53 | 6-4 | .600 | - | BTN | Welsh-Ryan Arena · Evanston, IL |
| 11 | Tue Dec 16 | vsValparaiso | W86-70 | 7-4 | .636 | - | Peacock | Welsh-Ryan Arena · Evanston, IL |
| 12 | Sat Dec 20 | atButler | L58-61 | 7-5 | .583 | - | Peacock | Hinkle Fieldhouse · Indianapolis, IN |
| 13 | Tue Dec 30 | vsHoward | W80-60 | 8-5 | .615 | - | BTN | Welsh-Ryan Arena · Evanston, IL |
| 14 | Sat Jan 3 | vsMinnesota | L78-84 | 8-6 | .571 | - | BTN | Welsh-Ryan Arena · Evanston, IL |
| 15 | Thu Jan 8 | at12Michigan St | L66-76 | 8-7 | .533 | - | BTN | Breslin Center · East Lansing, MI |
| 16 | Sun Jan 11 | atRutgers | L75-77 (OT) | 8-8 | .500 | - | Peacock | Jersey Mike’s Arena · Piscataway, NJ |
| 17 | Wed Jan 14 | vs13Illinois | L68-79 | 8-9 | .471 | - | BTN | Welsh-Ryan Arena · Evanston, IL |
| 18 | Sat Jan 17 | vs8Nebraska | L58-77 | 8-10 | .444 | - | BTN | Welsh-Ryan Arena · Evanston, IL |
| 19 | Wed Jan 21 | atUSC | W74-68 | 9-10 | .474 | - | BTN | Galen Center · Los Angeles, CA |
| 20 | Sat Jan 24 | atUCLA | L64-71 | 9-11 | .450 | - | FS1 | Pauley Pavilion · Los Angeles, CA |
| 21 | Thu Jan 29 | vsPenn State | W94-73 | 10-11 | .476 | - | Peacock | Welsh-Ryan Arena · Evanston, IL |
| 22 | Sat Jan 31 | vsWashington | L62-76 | 10-12 | .455 | - | BTN | Welsh-Ryan Arena · Evanston, IL |
| 23 | Wed Feb 4 | at5Illinois | L44-84 | 10-13 | .435 | - | BTN | State Farm Center · Champaign, IL |
| 24 | Sun Feb 8 | atIowa | L70-76 | 10-14 | .417 | - | FS1 | Carver-Hawkeye Arena · Iowa City, IA |
| 25 | Wed Feb 11 | vs2Michigan | L75-87 | 10-15 | .400 | - | BTN | Welsh-Ryan Arena · Evanston, IL |
| 26 | Sat Feb 14 | at7Nebraska | L49-68 | 10-16 | .385 | - | BTN | Pinnacle Bank Arena · Lincoln, NE |
| 27 | Wed Feb 18 | vsMaryland | W78-74 | 11-16 | .407 | - | BTN | Welsh-Ryan Arena · Evanston, IL |
| 28 | Tue Feb 24 | atIndiana | W72-68 | 12-16 | .429 | - | FS1 | Simon Skjodt Assembly Hall · Bloomington, IN |
| 29 | Sat Feb 28 | vsOregon | W63-62 | 13-16 | .448 | - | BTN | Welsh-Ryan Arena · Evanston, IL |
