| 1 | Mon Nov 3 | vs Mercyhurst | 8:00 PM | 15-16 | .484 | - | B1G+ | Welsh-Ryan Arena · Evanston, IL |
| 2 | Fri Nov 7 | vsBoston Univ | TBD | 16-16 | .500 | - | Peacock | Welsh-Ryan Arena · Evanston, IL |
| 3 | Mon Nov 10 | vsCleveland St | TBD | 23-13 | .639 | - | | Welsh-Ryan Arena · Evanston, IL |
| 4 | Fri Nov 14 | atDePaul | TBD | 14-20 | .412 | - | | Wintrust Arena · Chicago, IL |
| 5 | Fri Nov 21 | vsVirginia | 5:00 PM | 15-17 | .469 | - | | Welsh-Ryan Arena · Evanston, IL |
| 6 | Sun Nov 23 | vsSouth Carolina | 5:00 PM | 12-20 | .375 | - | | Welsh-Ryan Arena · Evanston, IL |
| 7 | Thu Nov 27 | vsOklahoma St | 10:30 PM | 17-18 | .486 | - | Peacock | Welsh-Ryan Arena · Evanston, IL |
| 8 | Wed Dec 3 | at#24Wisconsin | TBD | 27-10 | .730 | - | | Kohl Center · Madison, WI |
| 9 | Sat Dec 6 | vsOhio State | TBD | 17-15 | .531 | - | | Welsh-Ryan Arena · Evanston, IL |
| 10 | Sat Dec 13 | vsJackson St | TBD | 16-18 | .471 | - | | Welsh-Ryan Arena · Evanston, IL |
| 11 | Tue Dec 16 | vsValparaiso | TBD | 15-19 | .441 | - | | Welsh-Ryan Arena · Evanston, IL |
| 12 | Sat Dec 20 | atButler | 4:00 PM | 15-20 | .429 | - | | Hinkle Fieldhouse · Indianapolis, IN |
| 13 | Tue Dec 30 | vsHoward | TBD | 12-20 | .375 | - | | Welsh-Ryan Arena · Evanston, IL |
| 14 | Sat Jan 3 | vsMinnesota | TBD | 15-17 | .469 | - | | Welsh-Ryan Arena · Evanston, IL |
| 15 | Thu Jan 8 | at#22Michigan St | TBD | 30-7 | .811 | - | | Breslin Center · East Lansing, MI |
| 16 | Sun Jan 11 | atRutgers | TBD | 15-17 | .469 | - | | Jersey Mike’s Arena · Piscataway, NJ |
| 17 | Wed Jan 14 | vs#17Illinois | TBD | 22-13 | .629 | - | | Welsh-Ryan Arena · Evanston, IL |
| 18 | Sat Jan 17 | vsNebraska | 4:00 PM | 21-14 | .600 | - | BTN | Welsh-Ryan Arena · Evanston, IL |
| 19 | Wed Jan 21 | atUSC | 11:00 PM | 17-18 | .486 | - | | Galen Center · Los Angeles, CA |
| 20 | Sat Jan 24 | at#12UCLA | 6:00 PM | 23-11 | .676 | - | | Pauley Pavilion · Los Angeles, CA |
| 21 | Thu Jan 29 | vsPenn State | 8:00 PM | 16-15 | .516 | - | Peacock | Welsh-Ryan Arena · Evanston, IL |
| 22 | Sat Jan 31 | vsWashington | TBD | 13-18 | .419 | - | | Welsh-Ryan Arena · Evanston, IL |
| 23 | Wed Feb 4 | at#17Illinois | TBD | 22-13 | .629 | - | | State Farm Center · Champaign, IL |
| 24 | Sun Feb 8 | atIowa | TBD | 17-16 | .515 | - | | Carver-Hawkeye Arena · Iowa City, IA |
| 25 | Wed Feb 11 | vs#7Michigan | TBD | 27-10 | .730 | - | | Welsh-Ryan Arena · Evanston, IL |
| 26 | Sat Feb 14 | atNebraska | 1:00 PM | 21-14 | .600 | - | BTN | Pinnacle Bank Arena · Lincoln, NE |
| 27 | Wed Feb 18 | vsMaryland | TBD | 27-9 | .750 | - | | Welsh-Ryan Arena · Evanston, IL |
| 28 | Tue Feb 24 | atIndiana | TBD | 19-13 | .594 | - | | Simon Skjodt Assembly Hall · Bloomington, IN |
| 29 | Sat Feb 28 | vsOregon | TBD | 25-10 | .714 | - | | Welsh-Ryan Arena · Evanston, IL |
| 30 | Wed Mar 4 | vs#1Purdue | TBD | 24-12 | .667 | - | | Welsh-Ryan Arena · Evanston, IL |
| 31 | Sat Mar 7 | atMinnesota | TBD | 15-17 | .469 | - | | Williams Arena · Minneapolis, MN |
