| 1 | Fri Nov 8 | vs Merrimack | L61-71 | 0-1 | .000 | - | | Welsh-Ryan Arena · Evanston, IL |
| 2 | Wed Nov 13 | vs Providence | W72-63 | 1-1 | .500 | - | BTN | Welsh-Ryan Arena · Evanston, IL |
| 3 | Tue Nov 19 | vs Radford | L56-67 | 1-2 | .333 | - | | Welsh-Ryan Arena · Evanston, IL |
| 4 | Fri Nov 22 | vs Norfolk St | W70-59 | 2-2 | .500 | - | | Welsh-Ryan Arena · Evanston, IL |
| 5 | Mon Nov 25 | at Bradley | W78-51 | 3-2 | .600 | - | FS1 | Carver Arena · Peoria, IL |
| 6 | Wed Nov 27 | at Pitt | L59-72 | 3-3 | .500 | - | | Petersen Events Center · Pittsburgh, PA |
| 7 | Tue Dec 3 | at Boston College | W82-64 | 4-3 | .571 | - | ESPNU | Silvio O. Conte Forum · Chestnut Hill, MA |
| 8 | Sun Dec 8 | at Purdue | L44-58 | 4-4 | .500 | - | BTN | Mackey Arena · West Lafayette, IN |
| 9 | Sun Dec 15 | vs SIUE | W72-54 | 5-4 | .556 | - | ESPNU | Welsh-Ryan Arena · Evanston, IL |
| 10 | Wed Dec 18 | vs #15Michigan St | L72-77 | 5-5 | .500 | - | BTN | Welsh-Ryan Arena · Evanston, IL |
| 11 | Sat Dec 21 | at DePaul | L78-83 | 5-6 | .455 | - | CBS | Wintrust Arena · Chicago, IL |
| 12 | Sun Dec 29 | vs TBD | L66-67 | 5-7 | .417 | - | BTN | Welsh-Ryan Arena · Evanston, IL |
| 13 | Sun Jan 5 | at Minnesota | L68-77 | 5-8 | .385 | - | BTN | Williams Arena · Minneapolis, MN |
| 14 | Wed Jan 8 | at Indiana | L62-66 | 5-9 | .357 | - | BTN | Simon Skjodt Assembly Hall · Bloomington, IN |
| 15 | Sat Jan 11 | vs Nebraska | W62-57 | 6-9 | .400 | - | BTN | Welsh-Ryan Arena · Evanston, IL |
| 16 | Tue Jan 14 | vs Iowa | L62-75 | 6-10 | .375 | - | BTN | Welsh-Ryan Arena · Evanston, IL |
| 17 | Sat Jan 18 | at #24Illinois | L71-75 | 6-11 | .353 | - | BTN | State Farm Center · Champaign, IL |
| 18 | Tue Jan 21 | vs #17Maryland | L66-77 | 6-12 | .333 | - | FS1 | Welsh-Ryan Arena · Evanston, IL |
| 19 | Sun Jan 26 | vs Ohio State | L59-71 | 6-13 | .316 | - | BTN | Welsh-Ryan Arena · Evanston, IL |
| 20 | Wed Jan 29 | at #14Michigan St | L50-79 | 6-14 | .300 | - | BTN | Breslin Center · East Lansing, MI |
| 21 | Sat Feb 1 | vs Purdue | L58-61 | 6-15 | .286 | - | BTN | Welsh-Ryan Arena · Evanston, IL |
| 22 | Sun Feb 9 | at Rutgers | L73-77 (OT) | 6-16 | .273 | - | BTN | Jersey Mike’s Arena · Piscataway, NJ |
| 23 | Wed Feb 12 | vs Michigan | L54-79 | 6-17 | .261 | - | BTN | Welsh-Ryan Arena · Evanston, IL |
| 24 | Sat Feb 15 | at #13Penn State | L61-77 | 6-18 | .250 | - | BTN | Bryce Jordan Center · University Park, PA |
| 25 | Tue Feb 18 | at Maryland | L67-76 | 6-19 | .240 | - | BTN | XFINITY Center · College Park, MD |
| 26 | Sun Feb 23 | vs Minnesota | L57-83 | 6-20 | .231 | - | BTN | Welsh-Ryan Arena · Evanston, IL |
| 27 | Thu Feb 27 | vs Illinois | L66-74 | 6-21 | .222 | - | BTN | Welsh-Ryan Arena · Evanston, IL |
| 28 | Sun Mar 1 | at Nebraska | W81-76 (OT) | 7-21 | .250 | - | BTN | Pinnacle Bank Arena · Lincoln, NE |
| 29 | Wed Mar 4 | at #24Wisconsin | L48-63 | 7-22 | .241 | - | BTN | Kohl Center · Madison, WI |
| 30 | Sat Mar 7 | vs #20Penn State | W80-69 | 8-22 | .267 | - | BTN | Welsh-Ryan Arena · Evanston, IL |
| 31 | Wed Mar 11 | at Minnesota | L57-74 | 8-23 | .258 | - | BTN | Williams Arena · Minneapolis, MN |