| 1 | Mon Nov 6 | vs Binghamton | W72-61 | 1-0 | 1.000 | - | | Welsh-Ryan Arena · Evanston, IL |
| 2 | Fri Nov 10 | vsDayton | W71-66 | 2-0 | 1.000 | - | BTN | Welsh-Ryan Arena · Evanston, IL |
| 3 | Tue Nov 14 | vsW Michigan | W63-59 | 3-0 | 1.000 | - | | Welsh-Ryan Arena · Evanston, IL |
| 4 | Sat Nov 18 | atRhode Island | W72-61 | 4-0 | 1.000 | - | | Ryan Center · Kingston, RI |
| 5 | Sun Nov 19 | atMississippi St | L57-66 | 4-1 | .800 | - | ESPN2 | Humphrey Coliseum · Starkville, MS |
| 6 | Mon Nov 27 | vsN Illinois | W89-67 | 5-1 | .833 | - | | Welsh-Ryan Arena · Evanston, IL |
| 7 | Fri Dec 1 | vs#1Purdue | W92-88 (OT) | 6-1 | .857 | - | BTN | Welsh-Ryan Arena · Evanston, IL |
| 8 | Sun Dec 10 | vsDetroit Mercy | W91-59 | 7-1 | .875 | - | | Welsh-Ryan Arena · Evanston, IL |
| 9 | Wed Dec 13 | vsChicago St | L73-75 | 7-2 | .778 | #25 | BTN | Welsh-Ryan Arena · Evanston, IL |
| 10 | Sat Dec 16 | atDePaul | W56-46 | 8-2 | .800 | #25 | FS1 | Wintrust Arena · Chicago, IL |
| 11 | Wed Dec 20 | atArizona St | W65-46 | 9-2 | .818 | - | ESPN2 | Desert Financial Arena · Tempe, AZ |
| 12 | Fri Dec 29 | vsJackson St | W74-63 | 10-2 | .833 | - | | Welsh-Ryan Arena · Evanston, IL |
| 13 | Tue Jan 2 | at#9Illinois | L66-96 | 10-3 | .769 | - | BTN | State Farm Center · Champaign, IL |
| 14 | Sun Jan 7 | vsMichigan St | W88-74 | 11-3 | .786 | - | | Welsh-Ryan Arena · Evanston, IL |
| 15 | Wed Jan 10 | atPenn State | W76-72 | 12-3 | .800 | - | BTN | Bryce Jordan Center · University Park, PA |
| 16 | Sat Jan 13 | at#15Wisconsin | L63-71 | 12-4 | .750 | - | BTN | Kohl Center · Madison, WI |
| 17 | Wed Jan 17 | vsMaryland | W72-69 | 13-4 | .765 | - | BTN | Welsh-Ryan Arena · Evanston, IL |
| 18 | Sat Jan 20 | atNebraska | L69-75 | 13-5 | .722 | - | BTN | Pinnacle Bank Arena · Lincoln, NE |
| 19 | Wed Jan 24 | vs#10Illinois | W96-91 (OT) | 14-5 | .737 | - | BTN | Welsh-Ryan Arena · Evanston, IL |
| 20 | Sat Jan 27 | vsOhio State | W83-58 | 15-5 | .750 | - | BTN | Welsh-Ryan Arena · Evanston, IL |
| 21 | Wed Jan 31 | at#2Purdue | L96-105 (OT) | 15-6 | .714 | - | BTN | Mackey Arena · West Lafayette, IN |
| 22 | Sat Feb 3 | atMinnesota | L66-75 (OT) | 15-7 | .682 | - | BTN | Williams Arena · Minneapolis, MN |
| 23 | Wed Feb 7 | vsNebraska | W80-68 | 16-7 | .696 | - | BTN | Welsh-Ryan Arena · Evanston, IL |
| 24 | Sun Feb 11 | vsPenn State | W68-63 | 17-7 | .708 | - | BTN | Welsh-Ryan Arena · Evanston, IL |
| 25 | Thu Feb 15 | atRutgers | L60-63 | 17-8 | .680 | - | BTN | Jersey Mike’s Arena · Piscataway, NJ |
| 26 | Sun Feb 18 | atIndiana | W76-72 | 18-8 | .692 | - | FS1 | Simon Skjodt Assembly Hall · Bloomington, IN |
| 27 | Thu Feb 22 | vsMichigan | W76-62 | 19-8 | .704 | - | FS1 | Welsh-Ryan Arena · Evanston, IL |
| 28 | Wed Feb 28 | atMaryland | W68-61 | 20-8 | .714 | - | BTN | XFINITY Center · College Park, MD |
| 29 | Sat Mar 2 | vsIowa | L80-87 | 20-9 | .690 | - | BTN | Welsh-Ryan Arena · Evanston, IL |
| 30 | Wed Mar 6 | atMichigan St | L49-53 | 20-10 | .667 | - | BTN | Breslin Center · East Lansing, MI |
| 31 | Sat Mar 9 | vsMinnesota | W90-66 | 21-10 | .677 | - | BTN | Welsh-Ryan Arena · Evanston, IL |
| 32 | Fri Mar 15 | vsWisconsin | L61-70 | 21-11 | .656 | - | BTN | Welsh-Ryan Arena · Evanston, IL |
| 33 | Fri Mar 22 | at#8FAU | W77-65 (OT) | 22-11 | .667 | #9 | CBS | FAU Arena · Boca Raton, FL |
| 34 | Sun Mar 24 | at#1UConn | L58-75 | 22-12 | .647 | #9 | truTV | Gampel Pavilion · Storrs, CT |
