| 1 | Tue Nov 5 | vs Georgia Tech | L81-82 (OT) | 0-1 | .000 | - | ACC Network | PNC Arena · Raleigh, NC |
| 2 | Sun Nov 10 | vs Detroit Mercy | W84-65 | 1-1 | .500 | - | | PNC Arena · Raleigh, NC |
| 3 | Wed Nov 13 | vs FIU | W86-77 | 2-1 | .667 | - | | PNC Arena · Raleigh, NC |
| 4 | Sat Nov 16 | vs St Francis BK | W95-64 | 3-1 | .750 | - | | PNC Arena · Raleigh, NC |
| 5 | Tue Nov 19 | vs Alcorn St | W87-64 | 4-1 | .800 | - | | PNC Arena · Raleigh, NC |
| 6 | Sat Nov 23 | vs Little Rock | W74-58 | 5-1 | .833 | - | | PNC Arena · Raleigh, NC |
| 7 | Thu Nov 28 | at Memphis | L78-83 | 5-2 | .714 | - | ESPN2 | FedExForum · Memphis, TN |
| 8 | Wed Dec 4 | vs Wisconsin | W69-54 | 6-2 | .750 | - | ESPN2 | PNC Arena · Raleigh, NC |
| 9 | Sat Dec 7 | at Wake Forest | W91-82 | 7-2 | .778 | - | ACC Network | Lawrence Joel Veterans Memorial Coliseum · Winston-Salem, NC |
| 10 | Sun Dec 15 | at UNC Greensboro | W80-77 | 8-2 | .800 | - | | Greensboro Coliseum · Greensboro, NC |
| 11 | Thu Dec 19 | at #12Auburn | L73-79 | 8-3 | .727 | - | ESPN2 | Neville Arena · Auburn, AL |
| 12 | Sun Dec 22 | vs The Citadel | W83-63 | 9-3 | .750 | - | ACC Network | PNC Arena · Raleigh, NC |
| 13 | Sun Dec 29 | vs Appalachian St | W72-60 | 10-3 | .769 | - | ACC Network | PNC Arena · Raleigh, NC |
| 14 | Sat Jan 4 | at Clemson | L70-81 | 10-4 | .714 | - | ACC Network | Littlejohn Coliseum · Clemson, SC |
| 15 | Wed Jan 8 | vs Notre Dame | W73-68 | 11-4 | .733 | - | ESPN2 | PNC Arena · Raleigh, NC |
| 16 | Sat Jan 11 | at Virginia Tech | L58-72 | 11-5 | .688 | - | | Cassell Coliseum · Blacksburg, VA |
| 17 | Wed Jan 15 | vs Miami | W80-63 | 12-5 | .706 | - | | PNC Arena · Raleigh, NC |
| 18 | Sat Jan 18 | vsClemson | W60-54 | 13-5 | .722 | - | | PNC Arena · Raleigh, NC |
| 19 | Mon Jan 20 | at Virginia | W53-51 | 14-5 | .737 | - | ESPN | John Paul Jones Arena · Charlottesville, VA |
| 20 | Sat Jan 25 | atGeorgia Tech | L58-64 | 14-6 | .700 | - | | McCamish Pavilion · Atlanta, GA |
| 21 | Mon Jan 27 | vs UNC | L65-75 | 14-7 | .667 | - | ESPN | PNC Arena · Raleigh, NC |
| 22 | Sat Feb 1 | vs #6Louisville | L57-77 | 14-8 | .636 | - | ESPN | PNC Arena · Raleigh, NC |
| 23 | Wed Feb 5 | atMiami | W83-72 | 15-8 | .652 | - | ACC Network | Watsco Center · Coral Gables, FL |
| 24 | Tue Feb 11 | at Syracuse | W79-74 | 16-8 | .667 | - | ESPN2 | JMA Wireless Dome · Syracuse, NY |
| 25 | Sun Feb 16 | at Boston College | L68-71 | 16-9 | .640 | - | ACC Network | Silvio O. Conte Forum · Chestnut Hill, MA |
| 26 | Wed Feb 19 | vs #6Duke | W88-66 | 17-9 | .654 | - | ESPN | PNC Arena · Raleigh, NC |
| 27 | Sat Feb 22 | vs #8Florida St | L61-67 | 17-10 | .630 | - | ACC Network | PNC Arena · Raleigh, NC |
| 28 | Tue Feb 25 | atUNC | L79-85 | 17-11 | .607 | - | ESPN | Dean E. Smith Center · Chapel Hill, NC |
| 29 | Sat Feb 29 | vs Pitt | W77-73 | 18-11 | .621 | - | ACC Network | PNC Arena · Raleigh, NC |
| 30 | Mon Mar 2 | at#12Duke | L69-88 | 18-12 | .600 | - | ESPN | Cameron Indoor Stadium · Durham, NC |
| 31 | Fri Mar 6 | vsWake Forest | W84-64 | 19-12 | .613 | - | ACC Network | PNC Arena · Raleigh, NC |
| 32 | Wed Mar 11 | vsPitt | W73-58 | 20-12 | .625 | - | ESPN | PNC Arena · Raleigh, NC |
