| 1 | Tue Nov 7 | vs FAMU | W105-54 | 1-0 | 1.000 | #8 | FS1 | CHI Health Center Omaha · Omaha, NE |
| 2 | Sat Nov 11 | vs N Dakota St | W89-60 | 2-0 | 1.000 | #8 | FS2 | CHI Health Center Omaha · Omaha, NE |
| 3 | Tue Nov 14 | vs Iowa | W92-84 | 3-0 | 1.000 | #8 | FS1 | CHI Health Center Omaha · Omaha, NE |
| 4 | Sat Nov 18 | vs Texas So | W82-50 | 4-0 | 1.000 | #8 | FS2 | CHI Health Center Omaha · Omaha, NE |
| 5 | Wed Nov 22 | vs Loyola Chicago | W88-65 | 5-0 | 1.000 | #8 | CBS | CHI Health Center Omaha · Omaha, NE |
| 6 | Thu Nov 23 | vs Colorado St | L48-69 | 5-1 | .833 | #8 | | CHI Health Center Omaha · Omaha, NE |
| 7 | Thu Nov 30 | at Oklahoma St | W79-65 | 6-1 | .857 | #15 | ESPN2 | Gallagher-Iba Arena · Stillwater, OK |
| 8 | Sun Dec 3 | at Nebraska | W89-60 | 7-1 | .875 | #15 | FS1 | Pinnacle Bank Arena · Lincoln, NE |
| 9 | Sat Dec 9 | vs C Michigan | W109-64 | 8-1 | .889 | #10 | FS2 | CHI Health Center Omaha · Omaha, NE |
| 10 | Wed Dec 13 | at UNLV | L64-79 | 8-2 | .800 | #8 | CBS | Thomas & Mack Center · Las Vegas, NV |
| 11 | Sat Dec 16 | vs Alabama | W85-82 | 9-2 | .818 | #8 | FOX | CHI Health Center Omaha · Omaha, NE |
| 12 | Wed Dec 20 | vs Villanova | L66-68 (OT) | 9-3 | .750 | #12 | FS1 | CHI Health Center Omaha · Omaha, NE |
| 13 | Sat Dec 30 | at #10Marquette | L67-72 | 9-4 | .692 | #22 | CBS | Fiserv Forum · Milwaukee, WI |
| 14 | Tue Jan 2 | at Georgetown | W77-60 | 10-4 | .714 | - | CBS | Capital One Arena · Washington, D.C. |
| 15 | Sat Jan 6 | vs #23Providence | W69-60 | 11-4 | .733 | - | FS1 | CHI Health Center Omaha · Omaha, NE |
| 16 | Tue Jan 9 | at DePaul | W84-58 | 12-4 | .750 | #22 | CBS | Wintrust Arena · Chicago, IL |
| 17 | Sat Jan 13 | vs St John's | W66-65 | 13-4 | .765 | #22 | FOX | CHI Health Center Omaha · Omaha, NE |
| 18 | Wed Jan 17 | at #1UConn | L48-62 | 13-5 | .722 | #18 | FS1 | Gampel Pavilion · Storrs, CT |
| 19 | Sat Jan 20 | at Seton Hall | W97-94 (3OT) | 14-5 | .737 | #18 | FS1 | Prudential Center · Newark, NJ |
| 20 | Tue Jan 23 | vs Xavier | W85-78 | 15-5 | .750 | #17 | FS1 | CHI Health Center Omaha · Omaha, NE |
| 21 | Sat Jan 27 | vsDePaul | W85-62 | 16-5 | .762 | #17 | FS1 | CHI Health Center Omaha · Omaha, NE |
| 22 | Fri Feb 2 | vs Butler | L98-99 | 16-6 | .727 | #13 | FS1 | CHI Health Center Omaha · Omaha, NE |
| 23 | Wed Feb 7 | atProvidence | L87-91 (OT) | 16-7 | .696 | #19 | FS2 | Amica Mutual Pavilion · Providence, RI |
| 24 | Sat Feb 10 | atXavier | W78-71 | 17-7 | .708 | #19 | FOX | Cintas Center · Cincinnati, OH |
| 25 | Tue Feb 13 | vsGeorgetown | W94-72 | 18-7 | .720 | #17 | FS1 | CHI Health Center Omaha · Omaha, NE |
| 26 | Sat Feb 17 | atButler | W79-57 | 19-7 | .731 | #17 | FOX | Hinkle Fieldhouse · Indianapolis, IN |
| 27 | Tue Feb 20 | vs#1UConn | W85-66 | 20-7 | .741 | #15 | FS1 | CHI Health Center Omaha · Omaha, NE |
| 28 | Sun Feb 25 | atSt John's | L66-80 | 20-8 | .714 | #15 | CBS | Carnesecca Arena · Queens, NY |
| 29 | Wed Feb 28 | vsSeton Hall | W85-64 | 21-8 | .724 | #12 | FS1 | CHI Health Center Omaha · Omaha, NE |
| 30 | Sat Mar 2 | vs#5Marquette | W89-75 | 22-8 | .733 | #12 | FOX | CHI Health Center Omaha · Omaha, NE |
| 31 | Sat Mar 9 | atVillanova | W69-67 | 23-8 | .742 | #10 | FOX | Finneran Pavilion · Villanova, PA |
| 32 | Thu Mar 14 | vsProvidence | L73-78 | 23-9 | .719 | #8 | FS1 | CHI Health Center Omaha · Omaha, NE |
| 33 | Thu Mar 21 | vs #14Akron | W77-60 | 24-9 | .727 | #3 | TNT | CHI Health Center Omaha · Omaha, NE |
| 34 | Sat Mar 23 | vs #11Oregon | W86-73 (2OT) | 25-9 | .735 | #3 | TBS | CHI Health Center Omaha · Omaha, NE |
| 35 | Fri Mar 29 | at #2Tennessee | L75-82 | 25-10 | .714 | #3 | TBS | Thompson-Boling Arena · Knoxville, TN |
