| 1 | Mon Nov 6 | vs C Michigan | W89-59 | 1-0 | 1.000 | - | | Lloyd Noble Center · Norman, OK |
| 2 | Fri Nov 10 | vs Miss Valley St | W82-43 | 2-0 | 1.000 | - | | Lloyd Noble Center · Norman, OK |
| 3 | Tue Nov 14 | vs Texas St | W93-54 | 3-0 | 1.000 | - | | Lloyd Noble Center · Norman, OK |
| 4 | Fri Nov 17 | vs UT Rio Grande | W90-66 | 4-0 | 1.000 | - | | Lloyd Noble Center · Norman, OK |
| 5 | Thu Nov 23 | at Iowa | W79-67 | 5-0 | 1.000 | - | FS1 | Carver-Hawkeye Arena · Iowa City, IA |
| 6 | Fri Nov 24 | at #23USC | W72-70 | 6-0 | 1.000 | - | | Galen Center · Los Angeles, CA |
| 7 | Thu Nov 30 | vs AR-Pine Bluff | W107-86 | 7-0 | 1.000 | #25 | | Lloyd Noble Center · Norman, OK |
| 8 | Tue Dec 5 | vs Providence | W72-51 | 8-0 | 1.000 | #19 | ESPNU | Lloyd Noble Center · Norman, OK |
| 9 | Sat Dec 9 | vs Arkansas | W79-70 | 9-0 | 1.000 | #19 | ESPN2 | Lloyd Noble Center · Norman, OK |
| 10 | Sat Dec 16 | vs Green Bay | W81-47 | 10-0 | 1.000 | #11 | | Lloyd Noble Center · Norman, OK |
| 11 | Wed Dec 20 | vs #11UNC | L69-81 | 10-1 | .909 | #7 | ESPN | Lloyd Noble Center · Norman, OK |
| 12 | Thu Dec 28 | vs C Arkansas | W88-72 | 11-1 | .917 | #12 | | Lloyd Noble Center · Norman, OK |
| 13 | Sun Dec 31 | vs Monmouth | W72-56 | 12-1 | .923 | #12 | | Lloyd Noble Center · Norman, OK |
| 14 | Sat Jan 6 | vs Iowa State | W71-63 | 13-1 | .929 | #11 | | Lloyd Noble Center · Norman, OK |
| 15 | Wed Jan 10 | at TCU | L71-80 | 13-2 | .867 | #9 | ESPN2 | Ed and Rae Schollmaier Arena · Fort Worth, TX |
| 16 | Sat Jan 13 | at #3Kansas | L66-78 | 13-3 | .813 | #9 | | Allen Fieldhouse · Lawrence, KS |
| 17 | Wed Jan 17 | vs West Virginia | W77-63 | 14-3 | .824 | #15 | | Lloyd Noble Center · Norman, OK |
| 18 | Sat Jan 20 | at Cincinnati | W69-65 | 15-3 | .833 | #15 | | Fifth Third Arena · Cincinnati, OH |
| 19 | Tue Jan 23 | vs Texas | L60-75 | 15-4 | .789 | #11 | ESPN | Lloyd Noble Center · Norman, OK |
| 20 | Sat Jan 27 | vs #20Texas Tech | L84-85 | 15-5 | .750 | #11 | | Lloyd Noble Center · Norman, OK |
| 21 | Tue Jan 30 | at Kansas St | W73-53 | 16-5 | .762 | #23 | | Bramlage Coliseum · Manhattan, KS |
| 22 | Sat Feb 3 | at UCF | L63-74 | 16-6 | .727 | #23 | | Addition Financial Arena · Orlando, FL |
| 23 | Tue Feb 6 | vs #21BYU | W82-66 | 17-6 | .739 | - | | Lloyd Noble Center · Norman, OK |
| 24 | Sat Feb 10 | vs Oklahoma St | W66-62 | 18-6 | .750 | - | | Lloyd Noble Center · Norman, OK |
| 25 | Tue Feb 13 | at #12Baylor | L62-79 | 18-7 | .720 | #25 | ESPN2 | Ferrell Center · Waco, TX |
| 26 | Sat Feb 17 | vs#6Kansas | L57-67 | 18-8 | .692 | #25 | ESPN | Lloyd Noble Center · Norman, OK |
| 27 | Sat Feb 24 | atOklahoma St | W84-82 (OT) | 19-8 | .704 | - | ESPN2 | Gallagher-Iba Arena · Stillwater, OK |
| 28 | Wed Feb 28 | at#8Iowa State | L45-58 | 19-9 | .679 | - | | James H. Hilton Coliseum · Ames, IA |
| 29 | Sat Mar 2 | vs #1Houston | L85-87 | 19-10 | .655 | - | ESPN2 | Lloyd Noble Center · Norman, OK |
| 30 | Tue Mar 5 | vsCincinnati | W74-71 (OT) | 20-10 | .667 | - | | Lloyd Noble Center · Norman, OK |
| 31 | Sat Mar 9 | atTexas | L80-94 | 20-11 | .645 | - | ESPN | Moody Center · Austin, TX |
| 32 | Wed Mar 13 | atTCU | L70-77 | 20-12 | .625 | - | | Ed and Rae Schollmaier Arena · Fort Worth, TX |
