| 1 | Mon Nov 3 | at #8BYU | 9:30 PM | 26-10 | .722 | - | TNT | Marriott Center · Provo, UT |
| 2 | Sat Nov 8 | vsQueens | TBD | 20-15 | .571 | - | | Finneran Pavilion · Villanova, PA |
| 3 | Tue Nov 11 | vsSacred Heart | TBD | 15-18 | .455 | - | | Finneran Pavilion · Villanova, PA |
| 4 | Sat Nov 15 | vsDuquesne | TBD | 13-19 | .406 | - | | Finneran Pavilion · Villanova, PA |
| 5 | Wed Nov 19 | atLa Salle | TBD | 14-19 | .424 | - | | Tom Gola Arena · Philadelphia, PA |
| 6 | Tue Nov 25 | vsOld Dominion | TBD | 15-20 | .429 | - | | Finneran Pavilion · Villanova, PA |
| 7 | Mon Dec 1 | vsTemple | TBD | 17-15 | .531 | - | | Finneran Pavilion · Villanova, PA |
| 8 | Tue Dec 9 | at#7Michigan | TBD | 27-10 | .730 | - | | Crisler Center · Ann Arbor, MI |
| 9 | Sat Dec 13 | vsPitt | TBD | 17-15 | .531 | - | | Finneran Pavilion · Villanova, PA |
| 10 | Fri Dec 19 | vs#24Wisconsin | 8:00 PM | 27-10 | .730 | - | | Finneran Pavilion · Villanova, PA |
| 11 | Tue Dec 23 | atSeton Hall | TBD | 7-25 | .219 | - | | Prudential Center · Newark, NJ |
| 12 | Wed Dec 31 | vsDePaul | TBD | 14-20 | .412 | - | | Finneran Pavilion · Villanova, PA |
| 13 | Sat Jan 3 | atButler | TBD | 15-20 | .429 | - | | Hinkle Fieldhouse · Indianapolis, IN |
| 14 | Wed Jan 7 | vs#23Creighton | TBD | 25-11 | .694 | - | | Finneran Pavilion · Villanova, PA |
| 15 | Sat Jan 10 | atMarquette | TBD | 23-11 | .676 | - | | Fiserv Forum · Milwaukee, WI |
| 16 | Tue Jan 13 | atProvidence | TBD | 12-20 | .375 | - | | Amica Mutual Pavilion · Providence, RI |
| 17 | Sat Jan 17 | vs#5St John's | TBD | 31-5 | .861 | - | | Finneran Pavilion · Villanova, PA |
| 18 | Wed Jan 21 | vsGeorgetown | TBD | 18-16 | .529 | - | | Finneran Pavilion · Villanova, PA |
| 19 | Sat Jan 24 | at#4UConn | 12:30 PM | 24-11 | .686 | - | | Gampel Pavilion · Storrs, CT |
| 20 | Fri Jan 30 | vsProvidence | TBD | 12-20 | .375 | - | | Finneran Pavilion · Villanova, PA |
| 21 | Wed Feb 4 | vsSeton Hall | TBD | 7-25 | .219 | - | | Finneran Pavilion · Villanova, PA |
| 22 | Sat Feb 7 | atGeorgetown | TBD | 18-16 | .529 | - | | Capital One Arena · Washington, D.C. |
| 23 | Tue Feb 10 | vsMarquette | TBD | 23-11 | .676 | - | | Finneran Pavilion · Villanova, PA |
| 24 | Sat Feb 14 | at#23Creighton | TBD | 25-11 | .694 | - | | CHI Health Center Omaha · Omaha, NE |
| 25 | Tue Feb 17 | atXavier | TBD | 22-12 | .647 | - | | Cintas Center · Cincinnati, OH |
| 26 | Sat Feb 21 | vs#4UConn | 7:00 PM | 24-11 | .686 | - | | Finneran Pavilion · Villanova, PA |
| 27 | Wed Feb 25 | vsButler | TBD | 15-20 | .429 | - | | Finneran Pavilion · Villanova, PA |
| 28 | Sat Feb 28 | at#5St John's | TBD | 31-5 | .861 | - | | Carnesecca Arena · Queens, NY |
| 29 | Wed Mar 4 | atDePaul | TBD | 14-20 | .412 | - | | Wintrust Arena · Chicago, IL |
| 30 | Sat Mar 7 | vsXavier | TBD | 22-12 | .647 | - | | Finneran Pavilion · Villanova, PA |
