| 1 | Tue Nov 5 | vs Army | W97-54 | 1-0 | 1.000 | #10 | FS1 | Finneran Pavilion · Villanova, PA |
| 2 | Wed Nov 13 | atOhio State | L51-76 | 1-1 | .500 | - | FS1 | Value City Arena · Columbus, OH |
| 3 | Sat Nov 16 | vsOhio | W78-54 | 2-1 | .667 | - | FS2 | Xfinity Mobile Arena · Philadelphia, PA |
| 4 | Thu Nov 21 | atMTSU | W98-69 | 3-1 | .750 | - | ESPN2 | The HTC Center · Conway, SC |
| 5 | Fri Nov 22 | atMississippi St | W83-76 | 4-1 | .800 | - | ESPN2 | The HTC Center · Conway, SC |
| 6 | Sun Nov 24 | atBaylor | L78-87 | 4-2 | .667 | - | ESPN | The HTC Center · Conway, SC |
| 7 | Sun Dec 1 | vsLa Salle | W83-72 | 5-2 | .714 | #22 | FS1 | Finneran Pavilion · Villanova, PA |
| 8 | Wed Dec 4 | vsPenn | W80-69 | 6-2 | .750 | #23 | FS1 | Finneran Pavilion · Villanova, PA |
| 9 | Sat Dec 7 | atSaint Joseph's | W78-66 | 7-2 | .778 | #23 | ESPN2 | Michael J. Hagan '85 Arena · Philadelphia, PA |
| 10 | Sat Dec 14 | vsDelaware | W78-70 | 8-2 | .800 | - | ESPN2 | Prudential Center · Newark, NJ |
| 11 | Sat Dec 21 | vs1Kansas | W56-55 | 9-2 | .818 | #18 | FOX | Xfinity Mobile Arena · Philadelphia, PA |
| 12 | Mon Dec 30 | vsXavier | W68-62 | 10-2 | .833 | #10 | FS1 | Finneran Pavilion · Villanova, PA |
| 13 | Sat Jan 4 | atMarquette | L60-71 | 10-3 | .769 | #10 | FOX | Fiserv Forum · Milwaukee, WI |
| 14 | Tue Jan 7 | atCreighton | W64-59 | 11-3 | .786 | #16 | FS1 | CHI Health Center Omaha · Omaha, NE |
| 15 | Sat Jan 11 | vsGeorgetown | W80-66 | 12-3 | .800 | #16 | FS1 | Xfinity Mobile Arena · Philadelphia, PA |
| 16 | Tue Jan 14 | vsDePaul | W79-75 (OT) | 13-3 | .813 | #14 | FS1 | Finneran Pavilion · Villanova, PA |
| 17 | Sat Jan 18 | vsUConn | W61-55 | 14-3 | .824 | #14 | FS1 | Xfinity Mobile Arena · Philadelphia, PA |
| 18 | Tue Jan 21 | vs13Butler | W76-61 | 15-3 | .833 | #9 | CBSSN | Finneran Pavilion · Villanova, PA |
| 19 | Sat Jan 25 | atProvidence | W64-60 | 16-3 | .842 | #9 | CBS | Amica Mutual Pavilion · Providence, RI |
| 20 | Tue Jan 28 | atSt John's | W79-59 | 17-3 | .850 | #8 | FS1 | Carnesecca Arena · Queens, NY |
| 21 | Sat Feb 1 | vsCreighton | L61-76 | 17-4 | .810 | #8 | FS1 | Xfinity Mobile Arena · Philadelphia, PA |
| 22 | Wed Feb 5 | at19Butler | L76-79 | 17-5 | .773 | #10 | FS1 | Hinkle Fieldhouse · Indianapolis, IN |
| 23 | Sat Feb 8 | vs12Seton Hall | L64-70 | 17-6 | .739 | #10 | FOX | Xfinity Mobile Arena · Philadelphia, PA |
| 24 | Wed Feb 12 | vs18Marquette | W72-71 | 18-6 | .750 | #15 | FS1 | Finneran Pavilion · Villanova, PA |
| 25 | Sun Feb 16 | atTemple | W76-56 | 19-6 | .760 | #15 | ESPN | Liacouras Center · Philadelphia, PA |
| 26 | Wed Feb 19 | atDePaul | W91-71 | 20-6 | .769 | #12 | CBSSN | Wintrust Arena · Chicago, IL |
| 27 | Sat Feb 22 | atXavier | W64-55 | 21-6 | .778 | #12 | FOX | Cintas Center · Cincinnati, OH |
| 28 | Wed Feb 26 | vsSt John's | W71-60 | 22-6 | .786 | #12 | FS1 | Finneran Pavilion · Villanova, PA |
| 29 | Sat Feb 29 | vsProvidence | L54-58 | 22-7 | .759 | #12 | FOX | Xfinity Mobile Arena · Philadelphia, PA |
| 30 | Wed Mar 4 | at8Seton Hall | W79-77 | 23-7 | .767 | #14 | FS1 | Prudential Center · Newark, NJ |
| 31 | Sat Mar 7 | atGeorgetown | W70-69 | 24-7 | .774 | #14 | FOX | Capital One Arena · Washington, D.C. |
