| 1 | Mon Nov 6 | vs American | W90-63 | 1-0 | 1.000 | #22 | | Finneran Pavilion · Villanova, PA |
| 2 | Fri Nov 10 | vsLe Moyne | W83-57 | 2-0 | 1.000 | #22 | FS1 | Finneran Pavilion · Villanova, PA |
| 3 | Mon Nov 13 | atPenn | L72-76 | 2-1 | .667 | #21 | | The Palestra · Philadelphia, PA |
| 4 | Fri Nov 17 | vsMaryland | W57-40 | 3-1 | .750 | #21 | FS1 | Finneran Pavilion · Villanova, PA |
| 5 | Wed Nov 22 | vsTexas Tech | W85-69 | 4-1 | .800 | - | ESPN2 | Finneran Pavilion · Villanova, PA |
| 6 | Thu Nov 23 | at14UNC | W83-81 (OT) | 5-1 | .833 | - | ESPN | Dean E. Smith Center · Chapel Hill, NC |
| 7 | Fri Nov 24 | vsMemphis | W79-63 | 6-1 | .857 | - | ESPNU | Finneran Pavilion · Villanova, PA |
| 8 | Wed Nov 29 | vsSaint Joseph's | L65-78 | 6-2 | .750 | #18 | FS1 | Finneran Pavilion · Villanova, PA |
| 9 | Sat Dec 2 | vsDrexel | L55-57 | 6-3 | .667 | #18 | | Xfinity Mobile Arena · Philadelphia, PA |
| 10 | Tue Dec 5 | atKansas St | L71-72 (OT) | 6-4 | .600 | - | ESPN2 | Bramlage Coliseum · Manhattan, KS |
| 11 | Sat Dec 9 | vsUCLA | W65-56 | 7-4 | .636 | - | FOX | Xfinity Mobile Arena · Philadelphia, PA |
| 12 | Wed Dec 20 | at12Creighton | W68-66 (OT) | 8-4 | .667 | - | FS1 | CHI Health Center Omaha · Omaha, NE |
| 13 | Sat Dec 23 | atDePaul | W84-48 | 9-4 | .692 | - | FS1 | Wintrust Arena · Chicago, IL |
| 14 | Wed Jan 3 | vsXavier | W66-65 | 10-4 | .714 | - | FS1 | Finneran Pavilion · Villanova, PA |
| 15 | Sat Jan 6 | vsSt John's | L71-81 | 10-5 | .667 | - | FOX | Finneran Pavilion · Villanova, PA |
| 16 | Fri Jan 12 | vsDePaul | W94-69 | 11-5 | .688 | - | FS1 | Finneran Pavilion · Villanova, PA |
| 17 | Mon Jan 15 | at17Marquette | L74-87 | 11-6 | .647 | - | FOX | Fiserv Forum · Milwaukee, WI |
| 18 | Sat Jan 20 | vs1UConn | L65-66 | 11-7 | .611 | - | FS1 | Xfinity Mobile Arena · Philadelphia, PA |
| 19 | Wed Jan 24 | atSt John's | L50-70 | 11-8 | .579 | - | FS1 | Carnesecca Arena · Queens, NY |
| 20 | Sat Jan 27 | atButler | L81-88 (2OT) | 11-9 | .550 | - | FS1 | Hinkle Fieldhouse · Indianapolis, IN |
| 21 | Tue Jan 30 | vs9Marquette | L80-85 | 11-10 | .524 | - | FS1 | Finneran Pavilion · Villanova, PA |
| 22 | Sun Feb 4 | vsProvidence | W68-50 | 12-10 | .545 | - | FS1 | Xfinity Mobile Arena · Philadelphia, PA |
| 23 | Wed Feb 7 | atXavier | L53-56 | 12-11 | .522 | - | FS1 | Cintas Center · Cincinnati, OH |
| 24 | Sun Feb 11 | vsSeton Hall | W80-54 | 13-11 | .542 | - | CBSSN | Xfinity Mobile Arena · Philadelphia, PA |
| 25 | Fri Feb 16 | atGeorgetown | W70-54 | 14-11 | .560 | - | CBSSN | Capital One Arena · Washington, D.C. |
| 26 | Tue Feb 20 | vsButler | W72-62 | 15-11 | .577 | - | FS1 | Finneran Pavilion · Villanova, PA |
| 27 | Sat Feb 24 | at1UConn | L54-78 | 15-12 | .556 | - | FOX | Gampel Pavilion · Storrs, CT |
| 28 | Tue Feb 27 | vsGeorgetown | W75-47 | 16-12 | .571 | - | FS1 | Finneran Pavilion · Villanova, PA |
| 29 | Sat Mar 2 | atProvidence | W71-60 | 17-12 | .586 | - | FOX | Amica Mutual Pavilion · Providence, RI |
| 30 | Wed Mar 6 | atSeton Hall | L56-66 | 17-13 | .567 | - | FS1 | Prudential Center · Newark, NJ |
| 31 | Sat Mar 9 | vs10Creighton | L67-69 | 17-14 | .548 | - | FOX | Xfinity Mobile Arena · Philadelphia, PA |
| 32 | Wed Mar 13 | vsDePaul | W58-57 | 18-14 | .563 | - | FS1 | Finneran Pavilion · Villanova, PA |
| 33 | Thu Mar 14 | at10Marquette | L65-71 (OT) | 18-15 | .545 | - | FS1 | Fiserv Forum · Milwaukee, WI |
| 34 | Wed Mar 20 | vsVCU | L61-70 | 18-16 | .529 | - | ESPN2 | Finneran Pavilion · Villanova, PA |
