| 1 | Mon Nov 3 | at Queens | 8:00 AM | 20-15 | .571 | - | | Curry Arena · Charlotte, NC |
| 2 | Fri Nov 7 | atGeorge Mason | 7:00 PM | 27-9 | .750 | - | ESPN+ | EagleBank Arena · Fairfax, VA |
| 3 | Tue Nov 11 | atCoast Car | TBD | 10-22 | .313 | - | | The HTC Center · Conway, SC |
| 4 | Sat Nov 15 | vsMercer | TBD | 14-19 | .424 | - | ESPN+ | Winthrop Coliseum · Rock Hill, SC |
| 5 | Tue Nov 18 | at#14Arkansas | 8:00 PM | 22-14 | .611 | - | SECN+ | Bud Walton Arena · Fayetteville, AR |
| 6 | Sun Nov 23 | atJackson St | TBD | 16-18 | .471 | - | | Lee E. Williams Athletic and Assembly Center · Jackson, MS |
| 7 | Tue Nov 25 | atNebraska | TBD | 21-14 | .600 | - | BTN | Pinnacle Bank Arena · Lincoln, NE |
| 8 | Sat Nov 29 | vsSC State | TBD | 20-13 | .606 | - | ESPN+ | Winthrop Coliseum · Rock Hill, SC |
| 9 | Tue Dec 2 | atLong Island | TBD | 17-16 | .515 | - | | Steinberg Wellness Center · Brooklyn, NY |
| 10 | Sat Dec 6 | vsCoast Car | TBD | 10-22 | .313 | - | | Winthrop Coliseum · Rock Hill, SC |
| 11 | Tue Dec 9 | vsTBD | TBD | 0-0 | .000 | - | | Winthrop Coliseum · Rock Hill, SC |
| 12 | Sat Dec 13 | vsTBD | TBD | 0-0 | .000 | - | | Winthrop Coliseum · Rock Hill, SC |
| 13 | Thu Dec 18 | atNorth Dakota | 8:00 PM | 12-21 | .364 | - | | Betty Engelstad Sioux Center · Grand Forks, ND |
| 14 | Sun Dec 21 | vsTBD | TBD | 0-0 | .000 | - | | Winthrop Coliseum · Rock Hill, SC |
| 15 | Sun Dec 28 | at#10Texas Tech | 2:00 PM | 28-9 | .757 | - | TNT | United Supermarkets Arena · Lubbock, TX |
| 16 | Wed Dec 31 | atLongwood | TBD | 18-14 | .563 | - | | Willett Hall · Farmville, VA |
| 17 | Sat Jan 3 | vsGardner-Webb | TBD | 11-20 | .355 | - | | Winthrop Coliseum · Rock Hill, SC |
| 18 | Wed Jan 7 | vsCharleston So | TBD | 10-22 | .313 | - | | Winthrop Coliseum · Rock Hill, SC |
| 19 | Sat Jan 10 | atSC Upstate | 2:00 PM | 6-26 | .188 | - | | G.B. Hodge Center · Spartanburg, SC |
| 20 | Wed Jan 14 | vsHigh Point | TBD | 29-6 | .829 | - | | Winthrop Coliseum · Rock Hill, SC |
| 21 | Sat Jan 17 | atUNC Asheville | TBD | 21-11 | .656 | - | | Kimmel Arena · Asheville, NC |
| 22 | Wed Jan 21 | vsRadford | TBD | 20-13 | .606 | - | | Winthrop Coliseum · Rock Hill, SC |
| 23 | Sat Jan 24 | atPresbyterian | TBD | 14-19 | .424 | - | | Ross E. Templeton P.E. Center · Clinton, SC |
| 24 | Sat Jan 31 | vsUNC Asheville | TBD | 21-11 | .656 | - | | Winthrop Coliseum · Rock Hill, SC |
| 25 | Wed Feb 4 | atRadford | TBD | 20-13 | .606 | - | | Donald N. Dedmon Center · Radford, VA |
| 26 | Sat Feb 7 | vsLongwood | TBD | 18-14 | .563 | - | | Winthrop Coliseum · Rock Hill, SC |
| 27 | Thu Feb 12 | atGardner-Webb | 7:00 PM | 11-20 | .355 | - | | Paul Porter Arena · Boiling Springs, NC |
| 28 | Thu Feb 19 | vsSC Upstate | TBD | 6-26 | .188 | - | | Winthrop Coliseum · Rock Hill, SC |
| 29 | Sat Feb 21 | atHigh Point | 4:00 PM | 29-6 | .829 | - | | Nido and Mariana Qubein Arena · High Point, NC |
| 30 | Thu Feb 26 | atCharleston So | 7:00 PM | 10-22 | .313 | - | | Buccaneer Fieldhouse · Charleston, SC |
| 31 | Sat Feb 28 | vsPresbyterian | TBD | 14-19 | .424 | - | | Winthrop Coliseum · Rock Hill, SC |
