| 1 | Mon Nov 6 | at #19UNC | L70-86 | 0-1 | .000 | - | ACC Network | Dean E. Smith Center · Chapel Hill, NC |
| 2 | Fri Nov 10 | vs Marshall | W66-62 | 1-1 | .500 | - | | Donald N. Dedmon Center · Radford, VA |
| 3 | Sun Nov 12 | vs TBD | W84-47 | 2-1 | .667 | - | | Donald N. Dedmon Center · Radford, VA |
| 4 | Wed Nov 15 | at VCU | L50-73 | 2-2 | .500 | - | | Stuart C. Siegel Center · Richmond, VA |
| 5 | Fri Nov 17 | at #24JMU | L73-76 | 2-3 | .400 | - | | Atlantic Union Bank Center · Harrisonburg, VA |
| 6 | Tue Nov 21 | vs Morgan St | W82-72 | 3-3 | .500 | - | | Donald N. Dedmon Center · Radford, VA |
| 7 | Wed Nov 22 | vs N Colorado | W79-68 | 4-3 | .571 | - | | Donald N. Dedmon Center · Radford, VA |
| 8 | Sun Nov 26 | vsTBD | W100-53 | 5-3 | .625 | - | | Donald N. Dedmon Center · Radford, VA |
| 9 | Wed Nov 29 | at Old Dominion | L68-69 | 5-4 | .556 | - | | Chartway Arena · Norfolk, VA |
| 10 | Sun Dec 3 | vs Elon | W82-72 | 6-4 | .600 | - | | Donald N. Dedmon Center · Radford, VA |
| 11 | Sat Dec 9 | vs NC Central | W82-74 | 7-4 | .636 | - | | Donald N. Dedmon Center · Radford, VA |
| 12 | Tue Dec 12 | vs VMI | W73-56 | 8-4 | .667 | - | | Donald N. Dedmon Center · Radford, VA |
| 13 | Sat Dec 16 | at Bucknell | W70-63 | 9-4 | .692 | - | | Sojka Pavilion · Lewisburg, PA |
| 14 | Wed Dec 20 | at West Virginia | W66-65 | 10-4 | .714 | - | | WVU Coliseum · Morgantown, WV |
| 15 | Fri Dec 29 | at #18Clemson | L58-93 | 10-5 | .667 | - | | Littlejohn Coliseum · Clemson, SC |
| 16 | Wed Jan 3 | vs High Point | L71-85 | 10-6 | .625 | - | | Donald N. Dedmon Center · Radford, VA |
| 17 | Thu Jan 11 | at Longwood | W69-58 | 11-6 | .647 | - | ESPNU | Willett Hall · Farmville, VA |
| 18 | Sat Jan 13 | at Winthrop | L88-92 (3OT) | 11-7 | .611 | - | | Winthrop Coliseum · Rock Hill, SC |
| 19 | Wed Jan 17 | vs Gardner-Webb | L68-74 | 11-8 | .579 | - | | Donald N. Dedmon Center · Radford, VA |
| 20 | Sat Jan 20 | vs SC Upstate | W64-61 | 12-8 | .600 | - | | Donald N. Dedmon Center · Radford, VA |
| 21 | Wed Jan 24 | at UNC Asheville | L69-81 | 12-9 | .571 | - | | Kimmel Arena · Asheville, NC |
| 22 | Sat Jan 27 | vs Presbyterian | W73-58 | 13-9 | .591 | - | | Donald N. Dedmon Center · Radford, VA |
| 23 | Wed Jan 31 | vs Charleston So | L60-63 | 13-10 | .565 | - | | Donald N. Dedmon Center · Radford, VA |
| 24 | Sat Feb 3 | atSC Upstate | L69-78 | 13-11 | .542 | - | | G.B. Hodge Center · Spartanburg, SC |
| 25 | Sat Feb 10 | atPresbyterian | L73-76 | 13-12 | .520 | - | | Ross E. Templeton P.E. Center · Clinton, SC |
| 26 | Thu Feb 15 | vsWinthrop | L69-85 | 13-13 | .500 | - | ESPNU | Donald N. Dedmon Center · Radford, VA |
| 27 | Sat Feb 17 | atHigh Point | L74-99 | 13-14 | .481 | - | | Nido and Mariana Qubein Arena · High Point, NC |
| 28 | Thu Feb 22 | atGardner-Webb | W90-74 | 14-14 | .500 | - | ESPNU | Paul Porter Arena · Boiling Springs, NC |
| 29 | Sat Feb 24 | vsLongwood | W88-82 | 15-14 | .517 | - | | Donald N. Dedmon Center · Radford, VA |
| 30 | Wed Feb 28 | atCharleston So | L57-58 | 15-15 | .500 | - | | Buccaneer Fieldhouse · Charleston, SC |
| 31 | Sat Mar 2 | vsUNC Asheville | L62-71 | 15-16 | .484 | - | | Donald N. Dedmon Center · Radford, VA |
| 32 | Wed Mar 6 | atSC Upstate | W67-60 | 16-16 | .500 | - | | G.B. Hodge Center · Spartanburg, SC |
| 33 | Fri Mar 8 | atHigh Point | L63-77 | 16-17 | .485 | - | | Nido and Mariana Qubein Arena · High Point, NC |
