| 1 | Mon Nov 7 | at Marquette | L69-79 | 0-1 | .000 | - | | Fiserv Forum · Milwaukee, WI |
| 2 | Thu Nov 10 | at Notre Dame | L76-79 | 0-2 | .000 | - | ACC Network | Purcell Pavilion · South Bend, IN |
| 3 | Mon Nov 14 | vs TBD | W97-46 | 1-2 | .333 | - | | Donald N. Dedmon Center · Radford, VA |
| 4 | Wed Nov 16 | vsTBD | W79-34 | 2-2 | .500 | - | | Donald N. Dedmon Center · Radford, VA |
| 5 | Sun Nov 20 | at Army | W90-75 | 3-2 | .600 | - | | Christl Arena · West Point, NY |
| 6 | Wed Nov 23 | at William & Mary | L51-62 | 3-3 | .500 | - | | Kaplan Arena · Williamsburg, VA |
| 7 | Sun Nov 27 | at Elon | W69-53 | 4-3 | .571 | - | | Schar Center · Elon, NC |
| 8 | Thu Dec 1 | vs NC Central | W80-78 | 5-3 | .625 | - | | Donald N. Dedmon Center · Radford, VA |
| 9 | Sun Dec 4 | vs G Washington | W86-76 | 6-3 | .667 | - | | Donald N. Dedmon Center · Radford, VA |
| 10 | Sat Dec 10 | at VMI | L74-77 | 6-4 | .600 | - | | Cameron Hall · Lexington, VA |
| 11 | Wed Dec 14 | at VCU | L62-70 | 6-5 | .545 | - | | Stuart C. Siegel Center · Richmond, VA |
| 12 | Sat Dec 17 | at E Kentucky | L65-67 | 6-6 | .500 | - | | McBrayer Arena · Richmond, KY |
| 13 | Wed Dec 21 | at Kansas St | L65-73 | 6-7 | .462 | - | | Bramlage Coliseum · Manhattan, KS |
| 14 | Thu Dec 29 | at UNC Asheville | L58-62 | 6-8 | .429 | - | | Kimmel Arena · Asheville, NC |
| 15 | Sat Dec 31 | vs Presbyterian | W69-51 | 7-8 | .467 | - | | Donald N. Dedmon Center · Radford, VA |
| 16 | Wed Jan 4 | vs SC Upstate | L60-65 | 7-9 | .438 | - | | Donald N. Dedmon Center · Radford, VA |
| 17 | Sat Jan 7 | at Gardner-Webb | W63-59 | 8-9 | .471 | - | | Paul Porter Arena · Boiling Springs, NC |
| 18 | Wed Jan 11 | at Winthrop | W66-52 | 9-9 | .500 | - | | Winthrop Coliseum · Rock Hill, SC |
| 19 | Sat Jan 14 | vs Charleston So | W75-70 | 10-9 | .526 | - | | Donald N. Dedmon Center · Radford, VA |
| 20 | Wed Jan 18 | at Campbell | W63-55 | 11-9 | .550 | - | | John W. Pope Jr. Convocation Center · Buies Creek, NC |
| 21 | Sat Jan 21 | vs High Point | W95-80 | 12-9 | .571 | - | | Donald N. Dedmon Center · Radford, VA |
| 22 | Thu Jan 26 | vs Longwood | W63-59 | 13-9 | .591 | - | ESPNU | Donald N. Dedmon Center · Radford, VA |
| 23 | Sat Jan 28 | atSC Upstate | W55-52 | 14-9 | .609 | - | | G.B. Hodge Center · Spartanburg, SC |
| 24 | Wed Feb 1 | atPresbyterian | W67-59 | 15-9 | .625 | - | | Ross E. Templeton P.E. Center · Clinton, SC |
| 25 | Sat Feb 4 | vsWinthrop | W69-66 | 16-9 | .640 | - | | Donald N. Dedmon Center · Radford, VA |
| 26 | Thu Feb 9 | vsGardner-Webb | L48-61 | 16-10 | .615 | - | ESPNU | Donald N. Dedmon Center · Radford, VA |
| 27 | Sat Feb 11 | atCharleston So | W90-71 | 17-10 | .630 | - | | Buccaneer Fieldhouse · Charleston, SC |
| 28 | Thu Feb 16 | vsUNC Asheville | L54-63 | 17-11 | .607 | - | ESPNU | Donald N. Dedmon Center · Radford, VA |
| 29 | Sat Feb 18 | atLongwood | L63-73 | 17-12 | .586 | - | | Willett Hall · Farmville, VA |
| 30 | Wed Feb 22 | atHigh Point | L64-69 | 17-13 | .567 | - | | Nido and Mariana Qubein Arena · High Point, NC |
| 31 | Sat Feb 25 | vsCampbell | W67-65 | 18-13 | .581 | - | | Donald N. Dedmon Center · Radford, VA |
| 32 | Fri Mar 3 | vsWinthrop | W78-69 | 19-13 | .594 | - | | Donald N. Dedmon Center · Radford, VA |
| 33 | Sat Mar 4 | vsCampbell | L71-72 | 19-14 | .576 | - | | Donald N. Dedmon Center · Radford, VA |
| 34 | Sun Mar 19 | vs Tarleton | W72-70 (OT) | 20-14 | .588 | - | | Donald N. Dedmon Center · Radford, VA |
| 35 | Mon Mar 20 | vs San Jose St | W67-57 | 21-14 | .600 | - | | Donald N. Dedmon Center · Radford, VA |
| 36 | Tue Mar 21 | vs Charlotte | L56-63 | 21-15 | .583 | - | ESPN2 | Donald N. Dedmon Center · Radford, VA |
