| 1 | Mon Nov 3 | vs TBD | W93-59 | 1-0 | 1.000 | - | | Daskalakis Athletic Center · Philadelphia, PA |
| 2 | Sat Nov 8 | atSaint Joseph's | L65-76 | 1-1 | .500 | - | ESPN+ | Michael J. Hagan '85 Arena · Philadelphia, PA |
| 3 | Tue Nov 11 | atColgate | L83-90 | 1-2 | .333 | - | ESPN+ | Cotterell Court · Hamilton, NY |
| 4 | Sat Nov 15 | atSyracuse | L50-80 | 1-3 | .250 | - | Peacock | JMA Wireless Dome · Syracuse, NY |
| 5 | Tue Nov 18 | vsNJIT | W75-43 | 2-3 | .400 | - | | Daskalakis Athletic Center · Philadelphia, PA |
| 6 | Fri Nov 21 | vsPenn | L68-84 | 2-4 | .333 | - | | Daskalakis Athletic Center · Philadelphia, PA |
| 7 | Sun Nov 23 | vsOld Dominion | W75-71 | 3-4 | .429 | - | | Daskalakis Athletic Center · Philadelphia, PA |
| 8 | Tue Nov 25 | atMorgan St | W71-66 | 4-4 | .500 | - | | Hill Field House · Baltimore, MD |
| 9 | Wed Dec 3 | atAmerican | L73-75 | 4-5 | .444 | - | ESPN+ | Bender Arena · Washington, D.C. |
| 10 | Sat Dec 6 | atLa Salle | L64-69 | 4-6 | .400 | - | | Tom Gola Arena · Philadelphia, PA |
| 11 | Tue Dec 16 | vsHoward | L66-74 | 4-7 | .364 | - | | Daskalakis Athletic Center · Philadelphia, PA |
| 12 | Fri Dec 19 | vsMount St Mary | W75-67 | 5-7 | .417 | - | | Daskalakis Athletic Center · Philadelphia, PA |
| 13 | Sun Dec 21 | vsMaine | W74-56 | 6-7 | .462 | - | | Daskalakis Athletic Center · Philadelphia, PA |
| 14 | Mon Dec 29 | atCharleston | L63-72 | 6-8 | .429 | - | The CW Network | TD Arena · Charleston, SC |
| 15 | Wed Dec 31 | atUNC Wilmington | L53-65 | 6-9 | .400 | - | | Trask Coliseum · Wilmington, NC |
| 16 | Sat Jan 3 | vsHofstra | L67-70 | 6-10 | .375 | - | | Daskalakis Athletic Center · Philadelphia, PA |
| 17 | Thu Jan 8 | vsStony Brook | W56-37 | 7-10 | .412 | - | | Daskalakis Athletic Center · Philadelphia, PA |
| 18 | Sat Jan 10 | vsWilliam & Mary | W64-58 | 8-10 | .444 | - | | Daskalakis Athletic Center · Philadelphia, PA |
| 19 | Thu Jan 15 | atMonmouth | W73-51 | 9-10 | .474 | - | | OceanFirst Bank Center · West Long Branch, NJ |
| 20 | Mon Jan 19 | atTowson | L58-59 | 9-11 | .450 | - | CBSSN | SECU Arena · Towson, MD |
| 21 | Sat Jan 24 | vsNortheastern | W83-78 | 10-11 | .476 | - | | Daskalakis Athletic Center · Philadelphia, PA |
| 22 | Thu Jan 29 | vsHampton | W58-51 | 11-11 | .500 | - | | Daskalakis Athletic Center · Philadelphia, PA |
| 23 | Sat Jan 31 | vsNC A&T | W61-60 | 12-11 | .522 | - | | Daskalakis Athletic Center · Philadelphia, PA |
| 24 | Thu Feb 5 | atCampbell | L60-81 | 12-12 | .500 | - | | John W. Pope Jr. Convocation Center · Buies Creek, NC |
| 25 | Sat Feb 7 | atElon | W82-77 | 13-12 | .520 | - | CBSSN | Schar Center · Elon, NC |
| 26 | Thu Feb 12 | vsMonmouth | L73-93 | 13-13 | .500 | - | | Daskalakis Athletic Center · Philadelphia, PA |
| 27 | Mon Feb 16 | atStony Brook | L69-72 | 13-14 | .481 | - | CBSSN | Island FCU Arena · Stony Brook, NY |
| 28 | Thu Feb 19 | atNortheastern | W70-61 | 14-14 | .500 | - | | Matthews Arena · Boston, MA |
| 29 | Sun Feb 22 | vsTowson | W68-62 | 15-14 | .517 | - | CBSSN | Daskalakis Athletic Center · Philadelphia, PA |
| 30 | Thu Feb 26 | vsCampbell | W65-60 | 16-14 | .533 | - | | Daskalakis Athletic Center · Philadelphia, PA |
