| 1 | Tue Nov 5 | at Temple | L62-70 | 0-1 | .000 | - | | Liacouras Center · Philadelphia, PA |
| 2 | Fri Nov 8 | vsNiagara | W72-64 | 1-1 | .500 | - | | Daskalakis Athletic Center · Philadelphia, PA |
| 3 | Sun Nov 10 | vsAbilene Chrstn | W86-83 (OT) | 2-1 | .667 | - | | Daskalakis Athletic Center · Philadelphia, PA |
| 4 | Wed Nov 13 | atRutgers | L57-62 | 2-2 | .500 | - | | Jersey Mike’s Arena · Piscataway, NJ |
| 5 | Sat Nov 16 | atSF Austin | L67-82 | 2-3 | .400 | - | | William R. Johnson Coliseum · Nacogdoches, TX |
| 6 | Wed Nov 20 | vsBryant | W86-74 | 3-3 | .500 | - | | Daskalakis Athletic Center · Philadelphia, PA |
| 7 | Mon Nov 25 | vsTBD | W84-51 | 4-3 | .571 | - | | Daskalakis Athletic Center · Philadelphia, PA |
| 8 | Sat Nov 30 | atUMBC | L60-85 | 4-4 | .500 | - | | Chesapeake Employers Insurance Arena · Baltimore, MD |
| 9 | Wed Dec 4 | vsPrinceton | W82-76 | 5-4 | .556 | - | | Daskalakis Athletic Center · Philadelphia, PA |
| 10 | Sat Dec 7 | vsLa Salle | L63-71 | 5-5 | .500 | - | | Daskalakis Athletic Center · Philadelphia, PA |
| 11 | Sun Dec 15 | atSouth Florida | L61-81 | 5-6 | .455 | - | | Yuengling Center · Tampa, FL |
| 12 | Fri Dec 20 | vsQuinnipiac | W72-63 | 6-6 | .500 | - | | Daskalakis Athletic Center · Philadelphia, PA |
| 13 | Sat Dec 21 | vsNorfolk St | W53-49 | 7-6 | .538 | - | | Daskalakis Athletic Center · Philadelphia, PA |
| 14 | Sat Dec 28 | vsCharleston | L65-76 | 7-7 | .500 | - | | Daskalakis Athletic Center · Philadelphia, PA |
| 15 | Mon Dec 30 | vsUNC Wilmington | W71-66 | 8-7 | .533 | - | | Daskalakis Athletic Center · Philadelphia, PA |
| 16 | Fri Jan 3 | vsDelaware | W61-55 | 9-7 | .563 | - | | Daskalakis Athletic Center · Philadelphia, PA |
| 17 | Thu Jan 9 | atTowson | L73-89 | 9-8 | .529 | - | CBS | SECU Arena · Towson, MD |
| 18 | Sat Jan 11 | atJMU | W78-71 | 10-8 | .556 | - | | Atlantic Union Bank Center · Harrisonburg, VA |
| 19 | Thu Jan 16 | vsElon | W63-41 | 11-8 | .579 | - | | Daskalakis Athletic Center · Philadelphia, PA |
| 20 | Sat Jan 18 | vsWilliam & Mary | W84-57 | 12-8 | .600 | - | | Daskalakis Athletic Center · Philadelphia, PA |
| 21 | Thu Jan 23 | atNortheastern | L52-85 | 12-9 | .571 | - | | Matthews Arena · Boston, MA |
| 22 | Sat Jan 25 | atHofstra | L59-72 | 12-10 | .545 | - | | David S. Mack Sports and Exhibition Complex · Hempstead, NY |
| 23 | Sat Feb 1 | atDelaware | L72-80 | 12-11 | .522 | - | | Bob Carpenter Center · Newark, DE |
| 24 | Thu Feb 6 | vsJMU | W78-67 | 13-11 | .542 | - | | Daskalakis Athletic Center · Philadelphia, PA |
| 25 | Sat Feb 8 | vsTowson | L69-76 | 13-12 | .520 | - | | Daskalakis Athletic Center · Philadelphia, PA |
| 26 | Thu Feb 13 | atWilliam & Mary | L72-77 | 13-13 | .500 | - | | Kaplan Arena · Williamsburg, VA |
| 27 | Sat Feb 15 | atElon | L70-75 | 13-14 | .481 | - | | Schar Center · Elon, NC |
| 28 | Thu Feb 20 | vsHofstra | L74-81 | 13-15 | .464 | - | | Daskalakis Athletic Center · Philadelphia, PA |
| 29 | Sat Feb 22 | vsNortheastern | L68-77 | 13-16 | .448 | - | | Daskalakis Athletic Center · Philadelphia, PA |
| 30 | Thu Feb 27 | atUNC Wilmington | L65-76 | 13-17 | .433 | - | | Trask Coliseum · Wilmington, NC |
| 31 | Sat Feb 29 | atCharleston | L66-75 | 13-18 | .419 | - | | TD Arena · Charleston, SC |
| 32 | Sat Mar 7 | vsUNC Wilmington | W66-55 | 14-18 | .438 | - | | Daskalakis Athletic Center · Philadelphia, PA |
| 33 | Sun Mar 8 | atHofstra | L43-61 | 14-19 | .424 | - | | David S. Mack Sports and Exhibition Complex · Hempstead, NY |
