| 1 | Sun Nov 10 | at NC State | L65-84 | 0-1 | .000 | - | | PNC Arena · Raleigh, NC |
| 2 | Sun Nov 17 | atClemson | L65-87 | 0-2 | .000 | - | | Littlejohn Coliseum · Clemson, SC |
| 3 | Tue Nov 19 | atWyoming | L49-76 | 0-3 | .000 | - | | Arena Auditorium · Laramie, WY |
| 4 | Sun Nov 24 | vsUC Irvine | W86-74 | 1-3 | .250 | - | | Calihan Hall · Detroit, MI |
| 5 | Mon Nov 25 | atLouisiana | L62-81 | 1-4 | .200 | - | | Cajundome · Lafayette, LA |
| 6 | Sat Nov 30 | atOhio | L81-91 | 1-5 | .167 | - | | Convocation Center (OH) · Athens, OH |
| 7 | Tue Dec 3 | atKent State | L57-92 | 1-6 | .143 | - | | M.A.C. Center · Kent, OH |
| 8 | Sat Dec 7 | vsE Michigan | L51-55 | 1-7 | .125 | - | | Calihan Hall · Detroit, MI |
| 9 | Tue Dec 10 | atNotre Dame | L71-110 | 1-8 | .111 | - | ACC Network | Purcell Pavilion · South Bend, IN |
| 10 | Sat Dec 14 | vsToledo | L72-80 | 1-9 | .100 | - | | Calihan Hall · Detroit, MI |
| 11 | Thu Dec 19 | vsNortheastern | L61-74 | 1-10 | .091 | - | | Calihan Hall · Detroit, MI |
| 12 | Sat Dec 21 | vsSIUE | W81-55 | 2-10 | .167 | - | | Calihan Hall · Detroit, MI |
| 13 | Sat Dec 28 | atOakland | L69-78 | 2-11 | .154 | - | | Athletics Center O'rena · Rochester, MI |
| 14 | Mon Dec 30 | at1Gonzaga | L72-93 | 2-12 | .143 | - | | McCarthey Athletic Center · Spokane, WA |
| 15 | Fri Jan 3 | vsN Kentucky | W66-58 | 3-12 | .200 | - | | Calihan Hall · Detroit, MI |
| 16 | Sun Jan 5 | vsWright St | L69-70 | 3-13 | .188 | - | | Calihan Hall · Detroit, MI |
| 17 | Thu Jan 9 | atCleveland St | L59-64 | 3-14 | .176 | - | | Wolstein Center · Cleveland, OH |
| 18 | Sat Jan 11 | atYoungstown St | L67-69 | 3-15 | .167 | - | | Beeghly Center · Youngstown, OH |
| 19 | Thu Jan 16 | atMilwaukee | W90-84 | 4-15 | .211 | - | | UW-Milwaukee Panther Arena · Milwaukee, WI |
| 20 | Sat Jan 18 | atGreen Bay | L80-83 | 4-16 | .200 | - | | Resch Center · Ashwaubenon, WI |
| 21 | Thu Jan 23 | vsIU Indy | W76-64 | 5-16 | .238 | - | | Calihan Hall · Detroit, MI |
| 22 | Sat Jan 25 | vsUIC | W70-69 | 6-16 | .273 | - | | Calihan Hall · Detroit, MI |
| 23 | Fri Jan 31 | vsOakland | L64-77 | 6-17 | .261 | - | | Calihan Hall · Detroit, MI |
| 24 | Thu Feb 6 | atWright St | L86-98 | 6-18 | .250 | - | | Nutter Center · Dayton, OH |
| 25 | Sat Feb 8 | atN Kentucky | L65-84 | 6-19 | .240 | - | | Truist Arena · Highland Heights, KY |
| 26 | Thu Feb 13 | vsYoungstown St | L72-76 | 6-20 | .231 | - | | Calihan Hall · Detroit, MI |
| 27 | Sat Feb 15 | vsCleveland St | L66-67 (OT) | 6-21 | .222 | - | | Calihan Hall · Detroit, MI |
| 28 | Fri Feb 21 | vsGreen Bay | L67-84 | 6-22 | .214 | - | | Calihan Hall · Detroit, MI |
| 29 | Sun Feb 23 | vsMilwaukee | W79-73 | 7-22 | .241 | - | | Calihan Hall · Detroit, MI |
| 30 | Thu Feb 27 | atUIC | L67-84 | 7-23 | .233 | - | | Credit Union 1 Arena · Chicago, IL |
| 31 | Sat Feb 29 | atIU Indy | W90-88 | 8-23 | .258 | - | | Indiana Farmers Coliseum · Indianapolis, IN |
