| 1 | Mon Nov 3 | at UIC | TBD | 17-14 | .548 | - | ESPN+ | Credit Union 1 Arena · Chicago, IL |
| 2 | Fri Nov 7 | atNotre Dame | TBD | 15-18 | .455 | - | | Purcell Pavilion · South Bend, IN |
| 3 | Tue Nov 11 | vsTBD | 7:00 PM | 0-0 | .000 | - | ESPN+ | Calihan Hall · Detroit, MI |
| 4 | Sat Nov 15 | atToledo | TBD | 18-15 | .545 | - | ESPN+ | Savage Arena · Toledo, OH |
| 5 | Tue Nov 18 | vsE Michigan | 7:00 PM | 16-16 | .500 | - | ESPN+ | Calihan Hall · Detroit, MI |
| 6 | Fri Nov 21 | at#22Michigan St | TBD | 30-7 | .811 | - | | Breslin Center · East Lansing, MI |
| 7 | Sun Nov 23 | atDePaul | TBD | 14-20 | .412 | - | | Wintrust Arena · Chicago, IL |
| 8 | Sat Nov 29 | atNiagara | 1:00 PM | 11-20 | .355 | - | ESPN+ | Gallagher Center · Niagara Falls, NY |
| 9 | Wed Dec 3 | vsIU Indy | 7:00 PM | 10-22 | .313 | - | | Calihan Hall · Detroit, MI |
| 10 | Sat Dec 6 | atCleveland St | 2:00 PM | 23-13 | .639 | - | | Wolstein Center · Cleveland, OH |
| 11 | Sun Dec 14 | atPurdue FW | 5:00 PM | 19-13 | .594 | - | | Allen County War Memorial Coliseum · Fort Wayne, IN |
| 12 | Sat Dec 20 | vsTBD | 1:00 PM | 0-0 | .000 | - | | Calihan Hall · Detroit, MI |
| 13 | Mon Dec 29 | atYoungstown St | 6:30 PM | 21-13 | .618 | - | | Beeghly Center · Youngstown, OH |
| 14 | Fri Jan 2 | vsRobert Morris | 7:00 PM | 26-9 | .743 | - | | Calihan Hall · Detroit, MI |
| 15 | Fri Jan 9 | vsWright St | 7:00 PM | 15-18 | .455 | - | | Calihan Hall · Detroit, MI |
| 16 | Sun Jan 11 | vsCleveland St | 1:00 PM | 23-13 | .639 | - | | Calihan Hall · Detroit, MI |
| 17 | Thu Jan 15 | atN Kentucky | 7:00 PM | 17-16 | .515 | - | | Truist Arena · Highland Heights, KY |
| 18 | Sat Jan 17 | atIU Indy | 2:00 PM | 10-22 | .313 | - | | Indiana Farmers Coliseum · Indianapolis, IN |
| 19 | Wed Jan 21 | vsPurdue FW | 7:00 PM | 19-13 | .594 | - | | Calihan Hall · Detroit, MI |
| 20 | Sat Jan 24 | vsOakland | 3:00 PM | 16-18 | .471 | - | | Calihan Hall · Detroit, MI |
| 21 | Fri Jan 30 | vsN Kentucky | 7:00 PM | 17-16 | .515 | - | | Calihan Hall · Detroit, MI |
| 22 | Wed Feb 4 | atMilwaukee | TBD | 21-11 | .656 | - | | UW-Milwaukee Panther Arena · Milwaukee, WI |
| 23 | Sat Feb 7 | atGreen Bay | 2:00 PM | 4-28 | .125 | - | | Resch Center · Ashwaubenon, WI |
| 24 | Thu Feb 12 | atWright St | TBD | 15-18 | .455 | - | | Nutter Center · Dayton, OH |
| 25 | Sun Feb 15 | vsYoungstown St | 1:00 PM | 21-13 | .618 | - | | Calihan Hall · Detroit, MI |
| 26 | Fri Feb 20 | vsMilwaukee | 7:00 PM | 21-11 | .656 | - | | Calihan Hall · Detroit, MI |
| 27 | Sun Feb 22 | vsGreen Bay | 1:00 PM | 4-28 | .125 | - | | Calihan Hall · Detroit, MI |
| 28 | Wed Feb 25 | atRobert Morris | 7:00 PM | 26-9 | .743 | - | | UPMC Events Center · Moon Township, PA |
| 29 | Sat Feb 28 | atOakland | 3:00 PM | 16-18 | .471 | - | | Athletics Center O'rena · Rochester, MI |
