| 1 | Mon Nov 3 | at CA Baptist | L75-87 | - | 0-1 | .000 | - | ESPN+ | CBU Events Center · Riverside, CA |
| 2 | Wed Nov 5 | atFresno St | W67-66 | - | 1-1 | .500 | - | | Save Mart Center · Fresno, CA |
| 3 | Sat Nov 8 | vsTBD | W105-46 | - | 2-1 | .667 | - | ESPN+ | G.B. Hodge Center · Spartanburg, SC |
| 4 | Wed Nov 12 | vsTBD | W114-53 | - | 3-1 | .750 | - | ESPN+ | G.B. Hodge Center · Spartanburg, SC |
| 5 | Sat Nov 15 | atUNC Wilmington | L60-73 | - | 3-2 | .600 | - | | Trask Coliseum · Wilmington, NC |
| 6 | Wed Nov 19 | vsTennessee Tech | L84-88 | - | 3-3 | .500 | - | ESPN+ | G.B. Hodge Center · Spartanburg, SC |
| 7 | Fri Nov 21 | atW Georgia | L64-72 | - | 3-4 | .429 | - | ESPN+ | The Coliseum · Carrollton, GA |
| 8 | Tue Nov 25 | vsNC Central | W82-67 | -7½ | 4-4 | .500 | - | ESPN+ | G.B. Hodge Center · Spartanburg, SC |
| 9 | Sat Nov 29 | atNebraska | L63-72 | - | 4-5 | .444 | - | | Pinnacle Bank Arena · Lincoln, NE |
| 10 | Wed Dec 3 | vsCoast Car | W85-78 (OT) | -2½ | 5-5 | .500 | - | ESPN+ | G.B. Hodge Center · Spartanburg, SC |
| 11 | Sat Dec 6 | vsW Carolina | W78-67 | -2½ | 6-5 | .545 | - | ESPN+ | G.B. Hodge Center · Spartanburg, SC |
| 12 | Sat Dec 13 | at14UNC | L62-80 | +29½ | 6-6 | .500 | - | The CW | Dean E. Smith Center · Chapel Hill, NC |
| 13 | Tue Dec 16 | atSC State | W78-72 | -10½ | 7-6 | .538 | - | | S-H-M Memorial Center · Orangeburg, SC |
| 14 | Wed Dec 17 | vsTBD | W98-63 | - | 8-6 | .571 | - | ESPN+ | G.B. Hodge Center · Spartanburg, SC |
| 15 | Sat Dec 20 | atYoungstown St | L65-74 | +6½ | 8-7 | .533 | - | ESPN+ | Beeghly Center · Youngstown, OH |
| 16 | Wed Dec 31 | vsRadford | L69-76 | -1½ | 8-8 | .500 | - | ESPN+ | G.B. Hodge Center · Spartanburg, SC |
| 17 | Sat Jan 3 | atPresbyterian | L77-86 | +1½ | 8-9 | .471 | - | ESPN+ | Ross E. Templeton P.E. Center · Clinton, SC |
| 18 | Sat Jan 10 | vsWinthrop | L50-71 | +5½ | 8-10 | .444 | - | ESPN+ | G.B. Hodge Center · Spartanburg, SC |
| 19 | Wed Jan 14 | atCharleston So | W86-81 (OT) | +6½ | 9-10 | .474 | - | ESPN+ | Buccaneer Fieldhouse · Charleston, SC |
| 20 | Sat Jan 17 | atHigh Point | L69-89 | +16½ | 9-11 | .450 | - | ESPN+ | Nido and Mariana Qubein Arena · High Point, NC |
| 21 | Wed Jan 21 | vsUNC Asheville | L69-83 | -1½ | 9-12 | .429 | - | ESPN+ | G.B. Hodge Center · Spartanburg, SC |
| 22 | Fri Jan 23 | atGardner-Webb | L65-67 | -9½ | 9-13 | .409 | - | ESPN+ | Paul Porter Arena · Boiling Springs, NC |
| 23 | Thu Jan 29 | vsLongwood | W65-60 | +1½ | 10-13 | .435 | - | ESPN+ | G.B. Hodge Center · Spartanburg, SC |
| 24 | Wed Feb 4 | atUNC Asheville | L67-76 | +6½ | 10-14 | .417 | - | ESPN+ | Kimmel Arena · Asheville, NC |
| 25 | Sat Feb 7 | vsCharleston So | W100-94 (OT) | +1½ | 11-14 | .440 | - | ESPN+ | G.B. Hodge Center · Spartanburg, SC |
| 26 | Thu Feb 12 | vsHigh Point | L70-95 | +14½ | 11-15 | .423 | - | ESPN+ | G.B. Hodge Center · Spartanburg, SC |
| 27 | Sat Feb 14 | atLongwood | L75-82 (OT) | +6½ | 11-16 | .407 | - | ESPN+ | Willett Hall · Farmville, VA |
| 28 | Thu Feb 19 | atWinthrop | L64-68 | +13½ | 11-17 | .393 | - | ESPN+ | Winthrop Coliseum · Rock Hill, SC |
| 29 | Sat Feb 21 | vsPresbyterian | W76-74 | +1½ | 12-17 | .414 | - | ESPN+ | G.B. Hodge Center · Spartanburg, SC |
| 30 | Thu Feb 26 | atRadford | L59-71 | +7½ | 12-18 | .400 | - | ESPN+ | Donald N. Dedmon Center · Radford, VA |
| 31 | Sat Feb 28 | vsGardner-Webb | W71-61 | -11½ | 13-18 | .419 | - | ESPN+ | G.B. Hodge Center · Spartanburg, SC |
| 32 | Wed Mar 4 | vsGardner-Webb | L64-65 | -10½ | 13-19 | .406 | - | ESPN+ | Freedom Hall Civic Center · Johnson City, TN |
