| 1 | Tue Nov 5 | at Charleston | L55-74 | 0-1 | .000 | - | | TD Arena · Charleston, SC |
| 2 | Fri Nov 8 | vsTBD | W103-62 | 1-1 | .500 | - | | G.B. Hodge Center · Spartanburg, SC |
| 3 | Mon Nov 11 | atNC Central | L64-73 | 1-2 | .333 | - | | McDougald-McLendon Arena · Durham, NC |
| 4 | Wed Nov 13 | atVirginia Tech | L57-80 | 1-3 | .250 | - | | Cassell Coliseum · Blacksburg, VA |
| 5 | Mon Nov 18 | atAkron | L45-76 | 1-4 | .200 | - | | James A. Rhodes Arena · Akron, OH |
| 6 | Wed Nov 20 | atLouisville | L50-76 | 1-5 | .167 | - | ACC Network | KFC Yum! Center · Louisville, KY |
| 7 | Sat Nov 23 | vsYoungstown St | L61-66 | 1-6 | .143 | - | | G.B. Hodge Center · Spartanburg, SC |
| 8 | Sat Nov 30 | atCharlotte | L47-83 | 1-7 | .125 | - | | Dale F. Halton Arena · Charlotte, NC |
| 9 | Tue Dec 3 | vsE Kentucky | W79-67 | 2-7 | .222 | - | | G.B. Hodge Center · Spartanburg, SC |
| 10 | Sun Dec 8 | atFurman | L72-84 | 2-8 | .200 | - | | Timmons Arena · Greenville, SC |
| 11 | Wed Dec 18 | atSC State | W73-70 | 3-8 | .273 | - | | S-H-M Memorial Center · Orangeburg, SC |
| 12 | Sat Dec 21 | vsTBD | W92-74 | 4-8 | .333 | - | | G.B. Hodge Center · Spartanburg, SC |
| 13 | Sun Dec 29 | vsVMI | W91-82 | 5-8 | .385 | - | | G.B. Hodge Center · Spartanburg, SC |
| 14 | Thu Jan 2 | atCharleston So | L75-89 | 5-9 | .357 | - | | Buccaneer Fieldhouse · Charleston, SC |
| 15 | Sat Jan 4 | atLongwood | W73-56 | 6-9 | .400 | - | | Willett Hall · Farmville, VA |
| 16 | Wed Jan 8 | vsHampton | W83-73 | 7-9 | .438 | - | | G.B. Hodge Center · Spartanburg, SC |
| 17 | Thu Jan 16 | vsRadford | L59-63 | 7-10 | .412 | - | | G.B. Hodge Center · Spartanburg, SC |
| 18 | Sat Jan 18 | atGardner-Webb | L67-83 | 7-11 | .389 | - | | Paul Porter Arena · Boiling Springs, NC |
| 19 | Mon Jan 20 | vsHigh Point | L62-70 | 7-12 | .368 | - | | G.B. Hodge Center · Spartanburg, SC |
| 20 | Thu Jan 23 | atWinthrop | L53-79 | 7-13 | .350 | - | | Winthrop Coliseum · Rock Hill, SC |
| 21 | Sat Jan 25 | vsUNC Asheville | W80-63 | 8-13 | .381 | - | | G.B. Hodge Center · Spartanburg, SC |
| 22 | Thu Jan 30 | atPresbyterian | W77-74 | 9-13 | .409 | - | ESPNU | Ross E. Templeton P.E. Center · Clinton, SC |
| 23 | Sat Feb 1 | vsCampbell | W91-74 | 10-13 | .435 | - | | G.B. Hodge Center · Spartanburg, SC |
| 24 | Thu Feb 6 | atUNC Asheville | L71-84 | 10-14 | .417 | - | | Kimmel Arena · Asheville, NC |
| 25 | Sat Feb 8 | vsGardner-Webb | L57-88 | 10-15 | .400 | - | | G.B. Hodge Center · Spartanburg, SC |
| 26 | Mon Feb 10 | vsCharleston So | W66-52 | 11-15 | .423 | - | | G.B. Hodge Center · Spartanburg, SC |
| 27 | Sat Feb 15 | atHigh Point | L54-62 | 11-16 | .407 | - | | Nido and Mariana Qubein Arena · High Point, NC |
| 28 | Thu Feb 20 | vsLongwood | L58-68 | 11-17 | .393 | - | | G.B. Hodge Center · Spartanburg, SC |
| 29 | Sat Feb 22 | atRadford | L60-81 | 11-18 | .379 | - | | Donald N. Dedmon Center · Radford, VA |
| 30 | Thu Feb 27 | vsWinthrop | L82-90 | 11-19 | .367 | - | | G.B. Hodge Center · Spartanburg, SC |
| 31 | Sat Feb 29 | atHampton | W90-79 | 12-19 | .387 | - | | Convocation Center (VA) · Hampton, VA |
| 32 | Tue Mar 3 | vsHigh Point | W69-59 | 13-19 | .406 | - | | G.B. Hodge Center · Spartanburg, SC |
| 33 | Thu Mar 5 | atWinthrop | L70-106 | 13-20 | .394 | - | | Winthrop Coliseum · Rock Hill, SC |
