| 1 | Wed Nov 25 | vs TBD | L72-82 | 0-1 | .000 | - | | G.B. Hodge Center · Spartanburg, SC |
| 2 | Sat Nov 28 | atFurman | L63-91 | 0-2 | .000 | - | | Timmons Arena · Greenville, SC |
| 3 | Wed Dec 2 | vsE Kentucky | L78-95 | 0-3 | .000 | - | | G.B. Hodge Center · Spartanburg, SC |
| 4 | Sat Dec 5 | vsGeorgia So | L69-72 | 0-4 | .000 | - | | G.B. Hodge Center · Spartanburg, SC |
| 5 | Sat Dec 12 | vsWinthrop | L77-95 | 0-5 | .000 | - | | G.B. Hodge Center · Spartanburg, SC |
| 6 | Sun Dec 13 | vsWinthrop | L77-107 | 0-6 | .000 | - | | G.B. Hodge Center · Spartanburg, SC |
| 7 | Tue Dec 15 | atUNC Greensboro | L57-65 | 0-7 | .000 | - | | Greensboro Coliseum · Greensboro, NC |
| 8 | Wed Dec 23 | atTennessee | L60-80 | 0-8 | .000 | - | SEC Network | Thompson-Boling Arena · Knoxville, TN |
| 9 | Wed Dec 30 | atHigh Point | L52-63 | 0-9 | .000 | - | | Nido and Mariana Qubein Arena · High Point, NC |
| 10 | Thu Dec 31 | atHigh Point | W60-51 | 1-9 | .100 | - | | Nido and Mariana Qubein Arena · High Point, NC |
| 11 | Mon Jan 4 | vsLongwood | W71-69 | 2-9 | .182 | - | | G.B. Hodge Center · Spartanburg, SC |
| 12 | Tue Jan 5 | vsLongwood | W65-59 | 3-9 | .250 | - | | G.B. Hodge Center · Spartanburg, SC |
| 13 | Sat Jan 9 | atPresbyterian | PPD | 5-18 | .217 | - | | Ross E. Templeton P.E. Center · Clinton, SC |
| 14 | Sun Jan 10 | atPresbyterian | PPD | 5-18 | .217 | - | | Ross E. Templeton P.E. Center · Clinton, SC |
| 15 | Thu Jan 14 | vsHampton | L68-69 | 3-10 | .231 | - | | G.B. Hodge Center · Spartanburg, SC |
| 16 | Fri Jan 15 | vsHampton | L74-84 | 3-11 | .214 | - | | G.B. Hodge Center · Spartanburg, SC |
| 18 | Wed Jan 20 | atCharleston So | PPD | 5-18 | .217 | - | | Buccaneer Fieldhouse · Charleston, SC |
| 19 | Thu Feb 4 | atRadford | L61-63 | 3-12 | .200 | - | | Donald N. Dedmon Center · Radford, VA |
| 20 | Fri Feb 5 | atRadford | L66-102 | 3-13 | .188 | - | | Donald N. Dedmon Center · Radford, VA |
| 21 | Mon Feb 8 | vsGardner-Webb | W77-69 | 4-13 | .235 | - | | G.B. Hodge Center · Spartanburg, SC |
| 22 | Thu Feb 11 | atCampbell | L71-72 | 4-14 | .222 | - | | John W. Pope Jr. Convocation Center · Buies Creek, NC |
| 23 | Fri Feb 12 | atCampbell | L49-64 | 4-15 | .211 | - | | John W. Pope Jr. Convocation Center · Buies Creek, NC |
| 24 | Mon Feb 15 | atPresbyterian | L65-75 | 4-16 | .200 | - | | Ross E. Templeton P.E. Center · Clinton, SC |
| 25 | Thu Feb 18 | atPresbyterian | W65-51 | 5-16 | .238 | - | | Ross E. Templeton P.E. Center · Clinton, SC |
| 26 | Mon Feb 22 | vsGardner-Webb | L58-69 | 5-17 | .227 | - | | G.B. Hodge Center · Spartanburg, SC |
| 28 | Sat Feb 27 | atHigh Point | L60-65 | 5-18 | .217 | - | | Nido and Mariana Qubein Arena · High Point, NC |
