| 1 | Tue Nov 9 | at Clemson | L53-64 | 0-1 | .000 | - | | Littlejohn Coliseum · Clemson, SC |
| 2 | Fri Nov 12 | vsVMI | W73-72 (OT) | 1-1 | .500 | - | | Ross E. Templeton P.E. Center · Clinton, SC |
| 3 | Mon Nov 15 | vsThe Citadel | W74-70 (2OT) | 2-1 | .667 | - | | Ross E. Templeton P.E. Center · Clinton, SC |
| 4 | Thu Nov 18 | atCincinnati | L45-79 | 2-2 | .500 | - | | Fifth Third Arena · Cincinnati, OH |
| 5 | Wed Nov 24 | vsVMI | W59-54 | 3-2 | .600 | - | | Ross E. Templeton P.E. Center · Clinton, SC |
| 6 | Thu Nov 25 | atNew Orleans | W68-66 | 4-2 | .667 | - | | Lakefront Arena · New Orleans, LA |
| 7 | Fri Nov 26 | atC Arkansas | W75-66 | 5-2 | .714 | - | | Farris Center · Conway, AR |
| 8 | Tue Nov 30 | at#13Tennessee | L44-86 | 5-3 | .625 | - | SEC Network | Thompson-Boling Arena · Knoxville, TN |
| 9 | Fri Dec 3 | vsTBD | W90-61 | 6-3 | .667 | - | | Ross E. Templeton P.E. Center · Clinton, SC |
| 10 | Mon Dec 6 | atMorehead St | L66-71 | 6-4 | .600 | - | | Ellis T. Johnson Arena · Morehead, KY |
| 11 | Sun Dec 12 | atCharleston | L76-78 (OT) | 6-5 | .545 | - | | TD Arena · Charleston, SC |
| 12 | Wed Dec 15 | vsTBD | W98-33 | 7-5 | .583 | - | | Ross E. Templeton P.E. Center · Clinton, SC |
| 13 | Sat Dec 18 | vsWofford | L49-76 | 7-6 | .538 | - | | Ross E. Templeton P.E. Center · Clinton, SC |
| 14 | Tue Dec 21 | atFurman | L61-75 | 7-7 | .500 | - | | Timmons Arena · Greenville, SC |
| 15 | Thu Dec 30 | vsTBD | W91-49 | 8-7 | .533 | - | | Ross E. Templeton P.E. Center · Clinton, SC |
| 16 | Wed Jan 5 | atNC A&T | L57-65 | 8-8 | .500 | - | | Corbett Sports Center · Greensboro, NC |
| 17 | Sat Jan 8 | vsSC Upstate | L72-82 | 8-9 | .471 | - | | Ross E. Templeton P.E. Center · Clinton, SC |
| 18 | Wed Jan 12 | atGardner-Webb | L61-64 | 8-10 | .444 | - | | Paul Porter Arena · Boiling Springs, NC |
| 19 | Sat Jan 15 | atHampton | PPD | 12-20 | .375 | - | | Convocation Center (VA) · Hampton, VA |
| 20 | Thu Jan 20 | vsWinthrop | L58-60 | 8-11 | .421 | - | | Ross E. Templeton P.E. Center · Clinton, SC |
| 21 | Sat Jan 22 | vsLongwood | L70-71 | 8-12 | .400 | - | | Ross E. Templeton P.E. Center · Clinton, SC |
| 22 | Wed Jan 26 | atCharleston So | W62-61 | 9-12 | .429 | - | | Buccaneer Fieldhouse · Charleston, SC |
| 23 | Sat Jan 29 | vsUNC Asheville | L67-68 | 9-13 | .409 | - | | Ross E. Templeton P.E. Center · Clinton, SC |
| 24 | Wed Feb 2 | vsCampbell | W64-58 | 10-13 | .435 | - | | Ross E. Templeton P.E. Center · Clinton, SC |
| 25 | Sat Feb 5 | atRadford | W78-70 | 11-13 | .458 | - | | Donald N. Dedmon Center · Radford, VA |
| 26 | Mon Feb 7 | atHampton | L69-74 | 11-14 | .440 | - | | Convocation Center (VA) · Hampton, VA |
| 27 | Wed Feb 9 | vsHigh Point | L70-79 | 11-15 | .423 | - | | Ross E. Templeton P.E. Center · Clinton, SC |
| 28 | Sat Feb 12 | atWinthrop | L61-65 | 11-16 | .407 | - | | Winthrop Coliseum · Rock Hill, SC |
| 29 | Wed Feb 16 | atSC Upstate | L55-60 | 11-17 | .393 | - | | G.B. Hodge Center · Spartanburg, SC |
| 30 | Sat Feb 19 | vsGardner-Webb | L68-76 | 11-18 | .379 | - | | Ross E. Templeton P.E. Center · Clinton, SC |
| 31 | Wed Feb 23 | vsCharleston So | W68-48 | 12-18 | .400 | - | | Ross E. Templeton P.E. Center · Clinton, SC |
| 32 | Sat Feb 26 | atUNC Asheville | L96-98 (3OT) | 12-19 | .387 | - | | Kimmel Arena · Asheville, NC |
| 33 | Wed Mar 2 | atCampbell | L72-75 (2OT) | 12-20 | .375 | - | | John W. Pope Jr. Convocation Center · Buies Creek, NC |
