| 1 | Tue Nov 7 | at Vanderbilt | W68-62 | 1-0 | 1.000 | - | | Memorial Gymnasium (TN) · Nashville, TN |
| 2 | Thu Nov 9 | vs TBD | W100-58 | 2-0 | 1.000 | - | | Ross E. Templeton P.E. Center · Clinton, SC |
| 3 | Mon Nov 13 | vs The Citadel | W71-64 | 3-0 | 1.000 | - | | Ross E. Templeton P.E. Center · Clinton, SC |
| 4 | Thu Nov 16 | at North Florida | W81-69 | 4-0 | 1.000 | - | | UNF Arena · Jacksonville, FL |
| 5 | Fri Nov 17 | vs Maine | L66-80 | 4-1 | .800 | - | | Ross E. Templeton P.E. Center · Clinton, SC |
| 6 | Sat Nov 18 | at N'Western St | W78-75 | 5-1 | .833 | - | | Prather Coliseum · Natchitoches, LA |
| 7 | Wed Nov 22 | vs Tennessee Tech | L75-79 (OT) | 5-2 | .714 | - | | Ross E. Templeton P.E. Center · Clinton, SC |
| 8 | Mon Nov 27 | at Elon | L79-82 | 5-3 | .625 | - | | Schar Center · Elon, NC |
| 9 | Sat Dec 2 | at VMI | W75-71 | 6-3 | .667 | - | | Cameron Hall · Lexington, VA |
| 10 | Wed Dec 6 | vs FAMU | L60-65 | 6-4 | .600 | - | | Ross E. Templeton P.E. Center · Clinton, SC |
| 11 | Wed Dec 13 | vsTBD | W118-51 | 7-4 | .636 | - | | Ross E. Templeton P.E. Center · Clinton, SC |
| 12 | Sat Dec 16 | vs Kennesaw St | L84-94 | 7-5 | .583 | - | | Ross E. Templeton P.E. Center · Clinton, SC |
| 13 | Tue Dec 19 | at Furman | L61-76 | 7-6 | .538 | - | | Timmons Arena · Greenville, SC |
| 14 | Thu Dec 21 | at Wake Forest | L68-91 | 7-7 | .500 | - | | Lawrence Joel Veterans Memorial Coliseum · Winston-Salem, NC |
| 15 | Sat Dec 30 | vsTBD | W91-67 | 8-7 | .533 | - | | Ross E. Templeton P.E. Center · Clinton, SC |
| 16 | Wed Jan 3 | at Charleston So | W68-61 | 9-7 | .563 | - | | Buccaneer Fieldhouse · Charleston, SC |
| 17 | Sat Jan 6 | vs UNC Asheville | L80-84 | 9-8 | .529 | - | | Ross E. Templeton P.E. Center · Clinton, SC |
| 18 | Wed Jan 10 | vs Winthrop | L71-81 | 9-9 | .500 | - | | Ross E. Templeton P.E. Center · Clinton, SC |
| 19 | Sat Jan 13 | at Gardner-Webb | L60-76 | 9-10 | .474 | - | | Paul Porter Arena · Boiling Springs, NC |
| 20 | Wed Jan 17 | vs High Point | L83-86 | 9-11 | .450 | - | | Ross E. Templeton P.E. Center · Clinton, SC |
| 21 | Sat Jan 20 | at Longwood | L70-80 | 9-12 | .429 | - | | Willett Hall · Farmville, VA |
| 22 | Sat Jan 27 | at Radford | L58-73 | 9-13 | .409 | - | | Donald N. Dedmon Center · Radford, VA |
| 23 | Wed Jan 31 | vs SC Upstate | W80-73 | 10-13 | .435 | - | | Ross E. Templeton P.E. Center · Clinton, SC |
| 24 | Sat Feb 3 | atHigh Point | L68-78 | 10-14 | .417 | - | | Nido and Mariana Qubein Arena · High Point, NC |
| 25 | Wed Feb 7 | vsGardner-Webb | W77-75 | 11-14 | .440 | - | | Ross E. Templeton P.E. Center · Clinton, SC |
| 26 | Sat Feb 10 | vsRadford | W76-73 | 12-14 | .462 | - | | Ross E. Templeton P.E. Center · Clinton, SC |
| 27 | Wed Feb 14 | atUNC Asheville | L69-71 | 12-15 | .444 | - | | Kimmel Arena · Asheville, NC |
| 28 | Sat Feb 17 | vsLongwood | L73-81 | 12-16 | .429 | - | | Ross E. Templeton P.E. Center · Clinton, SC |
| 29 | Wed Feb 21 | atWinthrop | W78-55 | 13-16 | .448 | - | | Winthrop Coliseum · Rock Hill, SC |
| 30 | Wed Feb 28 | atSC Upstate | L72-74 | 13-17 | .433 | - | | G.B. Hodge Center · Spartanburg, SC |
| 31 | Sat Mar 2 | vsCharleston So | W72-65 | 14-17 | .452 | - | | Ross E. Templeton P.E. Center · Clinton, SC |
| 32 | Fri Mar 8 | atGardner-Webb | L60-61 | 14-18 | .438 | - | | Paul Porter Arena · Boiling Springs, NC |
| 33 | Sun Mar 24 | vs Montana | L79-82 (OT) | 14-19 | .424 | - | | Ross E. Templeton P.E. Center · Clinton, SC |
