| 1 | Mon Nov 3 | vs Navy | 7:00 PM | 15-19 | .441 | - | ESPN+ | Ross E. Templeton P.E. Center · Clinton, SC |
| 2 | Wed Nov 5 | vsTBD | TBD | 0-0 | .000 | - | ESPN+ | Ross E. Templeton P.E. Center · Clinton, SC |
| 3 | Sat Nov 8 | vsETSU | TBD | 19-13 | .594 | - | ESPN+ | Ross E. Templeton P.E. Center · Clinton, SC |
| 4 | Mon Nov 10 | atGeorgia St | 7:00 PM | 14-19 | .424 | - | | GSU Convocation Center · Atlanta, GA |
| 5 | Wed Nov 12 | atSouth Carolina | 7:00 PM | 12-20 | .375 | - | | Colonial Life Arena · Columbia, SC |
| 6 | Sun Nov 16 | atSacramento St | 4:00 PM | 7-25 | .219 | - | | The Nest · Sacramento, CA |
| 7 | Tue Nov 18 | atCalifornia | 10:00 PM | 14-19 | .424 | - | ACC Extra | Haas Pavilion · Berkeley, CA |
| 8 | Fri Nov 21 | at#12UCLA | 10:30 PM | 23-11 | .676 | - | | Pauley Pavilion · Los Angeles, CA |
| 9 | Wed Nov 26 | vsTBD | TBD | 0-0 | .000 | - | ESPN+ | Ross E. Templeton P.E. Center · Clinton, SC |
| 10 | Sun Nov 30 | vsThe Citadel | 4:00 PM | 5-25 | .167 | - | | Ross E. Templeton P.E. Center · Clinton, SC |
| 11 | Wed Dec 3 | atWofford | TBD | 19-16 | .543 | - | | Jerry Richardson Indoor Stadium · Spartanburg, SC |
| 12 | Sat Dec 6 | vsMorehead St | TBD | 15-17 | .469 | - | | Ross E. Templeton P.E. Center · Clinton, SC |
| 13 | Wed Dec 17 | atE Carolina | TBD | 19-14 | .576 | - | | Williams Arena at Minges Coliseum · Greenville, NC |
| 14 | Sun Dec 21 | atManhattan | 2:00 PM | 17-14 | .548 | - | | Draddy Gymnasium · Riverdale, NY |
| 15 | Sun Dec 28 | vsTBD | TBD | 0-0 | .000 | - | | Ross E. Templeton P.E. Center · Clinton, SC |
| 16 | Sat Jan 3 | vsSC Upstate | TBD | 6-26 | .188 | - | | Ross E. Templeton P.E. Center · Clinton, SC |
| 17 | Wed Jan 7 | atRadford | TBD | 20-13 | .606 | - | | Donald N. Dedmon Center · Radford, VA |
| 18 | Sat Jan 10 | atLongwood | TBD | 18-14 | .563 | - | | Willett Hall · Farmville, VA |
| 19 | Wed Jan 14 | vsUNC Asheville | TBD | 21-11 | .656 | - | | Ross E. Templeton P.E. Center · Clinton, SC |
| 20 | Sat Jan 17 | atGardner-Webb | 2:00 PM | 11-20 | .355 | - | | Paul Porter Arena · Boiling Springs, NC |
| 21 | Wed Jan 21 | vsCharleston So | TBD | 10-22 | .313 | - | | Ross E. Templeton P.E. Center · Clinton, SC |
| 22 | Sat Jan 24 | vsWinthrop | TBD | 23-11 | .676 | - | | Ross E. Templeton P.E. Center · Clinton, SC |
| 23 | Thu Jan 29 | atHigh Point | 7:00 PM | 29-6 | .829 | - | | Nido and Mariana Qubein Arena · High Point, NC |
| 24 | Sat Jan 31 | vsRadford | TBD | 20-13 | .606 | - | | Ross E. Templeton P.E. Center · Clinton, SC |
| 25 | Sat Feb 7 | vsGardner-Webb | TBD | 11-20 | .355 | - | | Ross E. Templeton P.E. Center · Clinton, SC |
| 26 | Thu Feb 12 | atCharleston So | 7:00 PM | 10-22 | .313 | - | | Buccaneer Fieldhouse · Charleston, SC |
| 27 | Sat Feb 14 | atUNC Asheville | TBD | 21-11 | .656 | - | | Kimmel Arena · Asheville, NC |
| 28 | Thu Feb 19 | vsLongwood | TBD | 18-14 | .563 | - | | Ross E. Templeton P.E. Center · Clinton, SC |
| 29 | Sat Feb 21 | atSC Upstate | 4:30 PM | 6-26 | .188 | - | | G.B. Hodge Center · Spartanburg, SC |
| 30 | Thu Feb 26 | vsHigh Point | TBD | 29-6 | .829 | - | | Ross E. Templeton P.E. Center · Clinton, SC |
| 31 | Sat Feb 28 | atWinthrop | TBD | 23-11 | .676 | - | | Winthrop Coliseum · Rock Hill, SC |
