| 1 | Tue Nov 9 | at E Carolina | L62-70 | 0-1 | .000 | - | | Williams Arena at Minges Coliseum · Greenville, NC |
| 2 | Thu Nov 11 | at Charleston | L74-106 | 0-2 | .000 | - | | TD Arena · Charleston, SC |
| 3 | Fri Nov 12 | at Loyola MD | L65-75 | 0-3 | .000 | - | | Reitz Arena · Baltimore, MD |
| 4 | Sat Nov 13 | vs Lipscomb | L81-93 | 0-4 | .000 | - | | S-H-M Memorial Center · Orangeburg, SC |
| 5 | Tue Nov 16 | at Georgia | L60-76 | 0-5 | .000 | - | | Stegeman Coliseum · Athens, GA |
| 6 | Thu Nov 18 | vs TBD | W67-53 | 1-5 | .167 | - | | S-H-M Memorial Center · Orangeburg, SC |
| 7 | Tue Nov 23 | vs SC Upstate | L78-82 | 1-6 | .143 | - | | S-H-M Memorial Center · Orangeburg, SC |
| 8 | Sun Nov 28 | vs The Citadel | L79-91 (OT) | 1-7 | .125 | - | | S-H-M Memorial Center · Orangeburg, SC |
| 9 | Fri Dec 3 | at South Florida | W65-64 | 2-7 | .222 | - | | Yuengling Center · Tampa, FL |
| 10 | Fri Dec 10 | vs High Point | W67-66 | 3-7 | .300 | - | | S-H-M Memorial Center · Orangeburg, SC |
| 11 | Tue Dec 14 | at #2Duke | L62-103 | 3-8 | .273 | - | ACC Network | Cameron Indoor Stadium · Durham, NC |
| 12 | Thu Dec 16 | vsTBD | W105-46 | 4-8 | .333 | - | | S-H-M Memorial Center · Orangeburg, SC |
| 13 | Sat Dec 18 | vs Tennessee St | W90-88 (OT) | 5-8 | .385 | - | | S-H-M Memorial Center · Orangeburg, SC |
| 14 | Mon Dec 20 | atThe Citadel | W74-57 | 6-8 | .429 | - | | McAlister Field House · Charleston, SC |
| 15 | Tue Dec 21 | at Charleston So | W75-65 | 7-8 | .467 | - | | Buccaneer Fieldhouse · Charleston, SC |
| 17 | Sun Jan 2 | vsTBD | PPD | 15-16 | .484 | - | | S-H-M Memorial Center · Orangeburg, SC |
| 18 | Sat Jan 8 | vs Coppin St | L65-74 | 7-9 | .438 | - | | S-H-M Memorial Center · Orangeburg, SC |
| 19 | Mon Jan 10 | vs Morgan St | L81-88 (OT) | 7-10 | .412 | - | | S-H-M Memorial Center · Orangeburg, SC |
| 20 | Sat Jan 15 | vs NC Central | PPD | 15-16 | .484 | - | | S-H-M Memorial Center · Orangeburg, SC |
| 21 | Tue Jan 18 | vsTBD | W102-67 | 8-10 | .444 | - | | S-H-M Memorial Center · Orangeburg, SC |
| 22 | Sat Jan 22 | at MD-Eastern | W69-60 | 9-10 | .474 | - | | Hytche Athletic Center · Princess Anne, MD |
| 23 | Mon Jan 24 | at Delaware St | W64-62 | 10-10 | .500 | - | | Memorial Hall (Dover, DE) · Dover, DE |
| 24 | Sat Jan 29 | vs Norfolk St | L69-87 | 10-11 | .476 | - | | S-H-M Memorial Center · Orangeburg, SC |
| 25 | Mon Jan 31 | vs Howard | W58-55 | 11-11 | .500 | - | | S-H-M Memorial Center · Orangeburg, SC |
| 26 | Mon Feb 7 | vsNC Central | W74-68 | 12-11 | .522 | - | | S-H-M Memorial Center · Orangeburg, SC |
| 27 | Sat Feb 12 | atCoppin St | W66-58 | 13-11 | .542 | - | | Physical Education Complex · Baltimore, MD |
| 28 | Mon Feb 14 | atMorgan St | L66-76 | 13-12 | .520 | - | | Hill Field House · Baltimore, MD |
| 29 | Sat Feb 19 | vsMD-Eastern | W70-63 | 14-12 | .538 | - | | S-H-M Memorial Center · Orangeburg, SC |
| 30 | Mon Feb 21 | vsDelaware St | W79-74 | 15-12 | .556 | - | | S-H-M Memorial Center · Orangeburg, SC |
| 31 | Sat Feb 26 | atNorfolk St | L59-63 | 15-13 | .536 | - | | Joseph G. Echols Hall · Norfolk, VA |
| 32 | Mon Feb 28 | atHoward | L62-72 | 15-14 | .517 | - | | Burr Gymnasium · Washington, D.C. |
| 33 | Thu Mar 3 | atNC Central | L62-67 | 15-15 | .500 | - | | McDougald-McLendon Arena · Durham, NC |
| 34 | Thu Mar 10 | atMorgan St | L77-80 | 15-16 | .484 | - | | Hill Field House · Baltimore, MD |
South Carolina