| 1 | Tue Nov 8 | at South Carolina | L77-80 | 0-1 | .000 | - | SEC Network | Colonial Life Arena · Columbia, SC |
| 2 | Sat Nov 12 | at Tennessee St | L61-80 | 0-2 | .000 | - | | Gentry Center · Nashville, TN |
| 3 | Mon Nov 14 | at Duquesne | L71-96 | 0-3 | .000 | - | CBS | UPMC Cooper Fieldhouse · Pittsburgh, PA |
| 4 | Thu Nov 17 | at #4Kentucky | L63-106 | 0-4 | .000 | - | SEC Network | Rupp Arena · Lexington, KY |
| 5 | Sat Nov 19 | at North Florida | L66-72 | 0-5 | .000 | - | | UNF Arena · Jacksonville, FL |
| 6 | Wed Nov 23 | at Wake Forest | L74-105 | 0-6 | .000 | - | ACC Network | Lawrence Joel Veterans Memorial Coliseum · Winston-Salem, NC |
| 7 | Sat Nov 26 | at Western KY | L64-90 | 0-7 | .000 | - | | E. A. Diddle Arena · Bowling Green, KY |
| 8 | Tue Nov 29 | at E Carolina | W73-68 | 1-7 | .125 | - | | Williams Arena at Minges Coliseum · Greenville, NC |
| 9 | Sat Dec 3 | at Furman | L76-88 | 1-8 | .111 | - | | Timmons Arena · Greenville, SC |
| 10 | Tue Dec 6 | at Winthrop | L67-81 | 1-9 | .100 | - | | Winthrop Coliseum · Rock Hill, SC |
| 11 | Sat Dec 10 | at SC Upstate | L84-89 (OT) | 1-10 | .091 | - | | G.B. Hodge Center · Spartanburg, SC |
| 12 | Tue Dec 13 | vs UNC Asheville | L84-94 | 1-11 | .083 | - | | S-H-M Memorial Center · Orangeburg, SC |
| 13 | Sat Dec 17 | vs Samford | W62-61 | 2-11 | .154 | - | | S-H-M Memorial Center · Orangeburg, SC |
| 14 | Tue Dec 20 | at Longwood | L77-104 | 2-12 | .143 | - | | Willett Hall · Farmville, VA |
| 15 | Tue Dec 27 | at Texas Tech | L71-110 | 2-13 | .133 | - | | United Supermarkets Arena · Lubbock, TX |
| 16 | Fri Dec 30 | vs TBD | W111-58 | 3-13 | .188 | - | | S-H-M Memorial Center · Orangeburg, SC |
| 17 | Sat Jan 7 | at Coppin St | L73-85 | 3-14 | .176 | - | | Physical Education Complex · Baltimore, MD |
| 18 | Mon Jan 9 | at Morgan St | L85-90 | 3-15 | .167 | - | | Hill Field House · Baltimore, MD |
| 19 | Sat Jan 14 | at NC Central | L67-71 | 3-16 | .158 | - | | McDougald-McLendon Arena · Durham, NC |
| 20 | Sat Jan 21 | vs MD-Eastern | L70-76 | 3-17 | .150 | - | | S-H-M Memorial Center · Orangeburg, SC |
| 21 | Mon Jan 23 | vs Delaware St | L85-88 (OT) | 3-18 | .143 | - | | S-H-M Memorial Center · Orangeburg, SC |
| 22 | Sat Jan 28 | at Norfolk St | L68-82 | 3-19 | .136 | - | | Joseph G. Echols Hall · Norfolk, VA |
| 23 | Mon Jan 30 | at Howard | L74-100 | 3-20 | .130 | - | | Burr Gymnasium · Washington, D.C. |
| 24 | Sat Feb 11 | vsCoppin St | W94-84 | 4-20 | .167 | - | | S-H-M Memorial Center · Orangeburg, SC |
| 25 | Mon Feb 13 | vsMorgan St | W74-62 | 5-20 | .200 | - | | S-H-M Memorial Center · Orangeburg, SC |
| 26 | Sat Feb 18 | atMD-Eastern | L62-78 | 5-21 | .192 | - | | Hytche Athletic Center · Princess Anne, MD |
| 27 | Mon Feb 20 | atDelaware St | L68-69 | 5-22 | .185 | - | | Memorial Hall (Dover, DE) · Dover, DE |
| 28 | Sat Feb 25 | vsNorfolk St | L76-88 | 5-23 | .179 | - | | S-H-M Memorial Center · Orangeburg, SC |
| 29 | Mon Feb 27 | vsHoward | L78-82 | 5-24 | .172 | - | | S-H-M Memorial Center · Orangeburg, SC |
| 30 | Thu Mar 2 | vsNC Central | L64-71 | 5-25 | .167 | - | | S-H-M Memorial Center · Orangeburg, SC |
| 31 | Wed Mar 8 | atHoward | L55-91 | 5-26 | .161 | - | | Burr Gymnasium · Washington, D.C. |
