| 1 | Mon Nov 3 | at #11Louisville | 9:00 PM | 27-8 | .771 | - | ACC Network | KFC Yum! Center · Louisville, KY |
| 2 | Fri Nov 7 | atSamford | TBD | 22-11 | .667 | - | ESPN+ | Pete Hanna Center · Homewood, AL |
| 3 | Mon Nov 10 | atNC A&T | 7:00 PM | 7-25 | .219 | - | | Corbett Sports Center · Greensboro, NC |
| 4 | Fri Nov 14 | atCharleston | TBD | 24-9 | .727 | - | | TD Arena · Charleston, SC |
| 5 | Wed Nov 19 | vsChattanooga | 7:00 PM | 29-9 | .763 | - | | S-H-M Memorial Center · Orangeburg, SC |
| 6 | Sun Nov 23 | atSouth Dakota | TBD | 19-14 | .576 | - | | Sanford Coyote Sports Center · Vermillion, SD |
| 7 | Tue Nov 25 | atMissouri | 8:00 PM | 22-12 | .647 | - | SECN+ | Mizzou Arena · Columbia, MO |
| 8 | Sat Nov 29 | atWinthrop | TBD | 23-11 | .676 | - | ESPN+ | Winthrop Coliseum · Rock Hill, SC |
| 9 | Mon Dec 1 | atChicago St | 12:00 PM | 4-28 | .125 | - | | Jones Convocation Center · Chicago, IL |
| 10 | Fri Dec 5 | atBethune | TBD | 17-16 | .515 | - | | Moore Gymnasium (FL) · Daytona Beach, FL |
| 11 | Mon Dec 8 | atCharleston So | 7:00 PM | 10-22 | .313 | - | | Buccaneer Fieldhouse · Charleston, SC |
| 12 | Fri Dec 12 | atQueens | 7:00 PM | 20-15 | .571 | - | | Curry Arena · Charlotte, NC |
| 13 | Tue Dec 16 | vsSC Upstate | 1:00 PM | 6-26 | .188 | - | | S-H-M Memorial Center · Orangeburg, SC |
| 14 | Fri Dec 19 | vsTBD | 12:00 PM | 0-0 | .000 | - | | S-H-M Memorial Center · Orangeburg, SC |
| 15 | Mon Dec 22 | atSouth Carolina | 4:00 PM | 12-20 | .375 | - | | Colonial Life Arena · Columbia, SC |
| 16 | Tue Dec 30 | at#18Tennessee | 8:00 PM | 30-8 | .789 | - | SEC Network | Thompson-Boling Arena · Knoxville, TN |
| 17 | Sat Jan 3 | vsHoward | TBD | 12-20 | .375 | - | | S-H-M Memorial Center · Orangeburg, SC |
| 18 | Sat Jan 10 | atMorgan St | TBD | 14-18 | .438 | - | | Hill Field House · Baltimore, MD |
| 19 | Mon Jan 12 | atCoppin St | 7:00 PM | 6-24 | .200 | - | | Physical Education Complex · Baltimore, MD |
| 20 | Sat Jan 17 | vsNorfolk St | TBD | 24-11 | .686 | - | | S-H-M Memorial Center · Orangeburg, SC |
| 21 | Tue Jan 20 | vsTBD | TBD | 0-0 | .000 | - | | S-H-M Memorial Center · Orangeburg, SC |
| 22 | Sat Jan 24 | vsMD-Eastern | TBD | 6-25 | .194 | - | | S-H-M Memorial Center · Orangeburg, SC |
| 23 | Mon Jan 26 | vsDelaware St | TBD | 16-14 | .533 | - | | S-H-M Memorial Center · Orangeburg, SC |
| 24 | Sat Jan 31 | vsNC Central | TBD | 14-19 | .424 | - | | S-H-M Memorial Center · Orangeburg, SC |
| 25 | Sat Feb 7 | atHoward | TBD | 12-20 | .375 | - | | Burr Gymnasium · Washington, D.C. |
| 26 | Sat Feb 14 | vsMorgan St | TBD | 14-18 | .438 | - | | S-H-M Memorial Center · Orangeburg, SC |
| 27 | Mon Feb 16 | vsCoppin St | 7:00 PM | 6-24 | .200 | - | | S-H-M Memorial Center · Orangeburg, SC |
| 28 | Sat Feb 21 | atNorfolk St | TBD | 24-11 | .686 | - | | Joseph G. Echols Hall · Norfolk, VA |
| 29 | Sat Feb 28 | atMD-Eastern | 4:30 PM | 6-25 | .194 | - | | Hytche Athletic Center · Princess Anne, MD |
| 30 | Mon Mar 2 | atDelaware St | 7:00 PM | 16-14 | .533 | - | | Memorial Hall (Dover, DE) · Dover, DE |
| 31 | Thu Mar 5 | atNC Central | 7:30 PM | 14-19 | .424 | - | | McDougald-McLendon Arena · Durham, NC |
