| 1 | Wed Nov 25 | vs Charleston | W79-60 | 1-0 | 1.000 | #16 | ACC Network | Dean E. Smith Center · Chapel Hill, NC |
| 2 | Mon Nov 30 | atUNLV | W78-51 | 2-0 | 1.000 | - | ESPN2 | Thomas & Mack Center · Las Vegas, NV |
| 3 | Tue Dec 1 | atStanford | W67-63 | 3-0 | 1.000 | - | ESPN | Maples Pavilion · Stanford, CA |
| 4 | Wed Dec 2 | vsTexas | L67-69 | 3-1 | .750 | - | ESPN | Dean E. Smith Center · Chapel Hill, NC |
| 5 | Tue Dec 8 | atIowa | L80-93 | 3-2 | .600 | - | ESPN | Carver-Hawkeye Arena · Iowa City, IA |
| 6 | Sat Dec 12 | vsNC Central | W73-67 | 4-2 | .667 | #16 | | Dean E. Smith Center · Chapel Hill, NC |
| 7 | Sat Dec 19 | atKentucky | W75-63 | 5-2 | .714 | - | CBS | Rupp Arena · Lexington, KY |
| 8 | Tue Dec 22 | atNC State | L76-79 | 5-3 | .625 | #17 | ACC Network | PNC Arena · Raleigh, NC |
| 9 | Wed Dec 30 | atGeorgia Tech | L67-72 | 5-4 | .556 | - | | McCamish Pavilion · Atlanta, GA |
| 10 | Sat Jan 2 | vsNotre Dame | W66-65 | 6-4 | .600 | - | ACC Network | Dean E. Smith Center · Chapel Hill, NC |
| 11 | Tue Jan 5 | atMiami | W67-65 | 7-4 | .636 | - | ESPN | Watsco Center · Coral Gables, FL |
| 13 | Tue Jan 12 | vsSyracuse | W81-75 | 8-4 | .667 | - | ACC Network | Dean E. Smith Center · Chapel Hill, NC |
| 14 | Sat Jan 16 | atFlorida St | L75-82 | 8-5 | .615 | - | ESPN | Donald L. Tucker Center · Tallahassee, FL |
| 15 | Wed Jan 20 | vsWake Forest | W80-73 | 9-5 | .643 | - | ACC Network | Dean E. Smith Center · Chapel Hill, NC |
| 16 | Sat Jan 23 | vsNC State | W86-76 | 10-5 | .667 | - | ESPN | Dean E. Smith Center · Chapel Hill, NC |
| 17 | Tue Jan 26 | atPitt | W75-65 | 11-5 | .688 | - | ACC Network | Petersen Events Center · Pittsburgh, PA |
| 18 | Tue Feb 2 | atClemson | L50-63 | 11-6 | .647 | - | ACC Network | Littlejohn Coliseum · Clemson, SC |
| 19 | Sat Feb 6 | atDuke | W91-87 | 12-6 | .667 | - | ESPN | Cameron Indoor Stadium · Durham, NC |
| 21 | Sat Feb 13 | at#9Virginia | L48-60 | 12-7 | .632 | - | ESPN | John Paul Jones Arena · Charlottesville, VA |
| 23 | Wed Feb 17 | vsNortheastern | W82-62 | 13-7 | .650 | - | | Dean E. Smith Center · Chapel Hill, NC |
| 24 | Sat Feb 20 | vsLouisville | W99-54 | 14-7 | .667 | - | ESPN | Dean E. Smith Center · Chapel Hill, NC |
| 26 | Wed Feb 24 | vsMarquette | L70-83 | 14-8 | .636 | - | ESPN2 | Dean E. Smith Center · Chapel Hill, NC |
| 27 | Sat Feb 27 | vs#11Florida St | W78-70 | 15-8 | .652 | - | ESPN | Dean E. Smith Center · Chapel Hill, NC |
| 28 | Mon Mar 1 | atSyracuse | L70-72 | 15-9 | .625 | - | ESPN | JMA Wireless Dome · Syracuse, NY |
| 29 | Sat Mar 6 | vsDuke | W91-73 | 16-9 | .640 | - | ESPN | Dean E. Smith Center · Chapel Hill, NC |
| 30 | Wed Mar 10 | vsNotre Dame | W101-59 | 17-9 | .654 | - | ACC Network | Greensboro Coliseum · Greensboro, NC |
| 31 | Thu Mar 11 | atVirginia Tech | W81-73 | 18-9 | .667 | - | ESPN | Greensboro Coliseum · Greensboro, NC |
| 32 | Fri Mar 12 | atFlorida St | L66-69 | 18-10 | .643 | - | ESPN | Greensboro Coliseum · Greensboro, NC |
| 33 | Fri Mar 19 | vs#9Wisconsin | L62-85 | 18-11 | .621 | #8 | CBS | Mackey Arena · West Lafayette, IN |
