| 1 | Mon Nov 3 | vs C Arkansas | W94-54 | 1-0 | 1.000 | #25 | ACC Network | Dean E. Smith Center · Chapel Hill, NC |
| 2 | Fri Nov 7 | vs19Kansas | W87-74 | 2-0 | 1.000 | #25 | ESPN | Dean E. Smith Center · Chapel Hill, NC |
| 3 | Tue Nov 11 | vsRadford | W89-74 | 3-0 | 1.000 | #18 | ACC Network | Dean E. Smith Center · Chapel Hill, NC |
| 4 | Fri Nov 14 | vsNC Central | W97-53 | 4-0 | 1.000 | #18 | ACC Network | Dean E. Smith Center · Chapel Hill, NC |
| 5 | Tue Nov 18 | vsNavy | W73-61 | 5-0 | 1.000 | #18 | ACC Network | Dean E. Smith Center · Chapel Hill, NC |
| 6 | Tue Nov 25 | vsSt Bonaventure | W85-70 | 6-0 | 1.000 | #16 | FS1 | Dean E. Smith Center · Chapel Hill, NC |
| 7 | Thu Nov 27 | vs11Michigan St | L58-74 | 6-1 | .857 | #16 | FOX | Dean E. Smith Center · Chapel Hill, NC |
| 8 | Tue Dec 2 | at18Kentucky | W67-64 | 7-1 | .875 | #16 | ESPN | Rupp Arena · Lexington, KY |
| 9 | Sun Dec 7 | vsGeorgetown | W81-61 | 8-1 | .889 | #16 | ESPN | Dean E. Smith Center · Chapel Hill, NC |
| 10 | Sat Dec 13 | vsSC Upstate | W80-62 | 9-1 | .900 | #14 | The CW Network | Dean E. Smith Center · Chapel Hill, NC |
| 11 | Tue Dec 16 | vsETSU | W77-58 | 10-1 | .909 | #12 | ACC Network | Dean E. Smith Center · Chapel Hill, NC |
| 12 | Sat Dec 20 | atOhio State | W71-70 | 11-1 | .917 | #12 | CBS | State Farm Arena · Atlanta, GA |
| 13 | Mon Dec 22 | vsE Carolina | W99-51 | 12-1 | .923 | #12 | ACC Network | Dean E. Smith Center · Chapel Hill, NC |
| 14 | Tue Dec 30 | vsFlorida St | W79-66 | 13-1 | .929 | #12 | ESPN2 | Dean E. Smith Center · Chapel Hill, NC |
| 15 | Sat Jan 3 | atSMU | L83-97 | 13-2 | .867 | #12 | The CW Network | Moody Coliseum · Dallas, TX |
| 16 | Sat Jan 10 | vsWake Forest | W87-84 | 14-2 | .875 | #17 | ACC Network | Dean E. Smith Center · Chapel Hill, NC |
| 17 | Wed Jan 14 | atStanford | L90-95 | 14-3 | .824 | #14 | ACC Network | Maples Pavilion · Stanford, CA |
| 18 | Sat Jan 17 | atCalifornia | L78-84 | 14-4 | .778 | #14 | ACC Network | Haas Pavilion · Berkeley, CA |
| 19 | Wed Jan 21 | vsNotre Dame | W91-69 | 15-4 | .789 | #22 | ESPN2 | Dean E. Smith Center · Chapel Hill, NC |
| 20 | Sat Jan 24 | at14Virginia | W85-80 | 16-4 | .800 | #22 | ESPN2 | John Paul Jones Arena · Charlottesville, VA |
| 21 | Sat Jan 31 | atGeorgia Tech | W91-75 | 17-4 | .810 | #16 | ACC Network | McCamish Pavilion · Atlanta, GA |
| 22 | Mon Feb 2 | vsSyracuse | W87-77 | 18-4 | .818 | #14 | ESPN | Dean E. Smith Center · Chapel Hill, NC |
| 23 | Sat Feb 7 | vs4Duke | W71-68 | 19-4 | .826 | #14 | ESPN | Dean E. Smith Center · Chapel Hill, NC |
| 24 | Tue Feb 10 | atMiami | L66-75 | 19-5 | .792 | #11 | ESPN | Watsco Center · Coral Gables, FL |
| 25 | Sat Feb 14 | vsPitt | W79-65 | 20-5 | .800 | #11 | ESPN | Dean E. Smith Center · Chapel Hill, NC |
| 26 | Tue Feb 17 | atNC State | L58-82 | 20-6 | .769 | #16 | ESPN | PNC Arena · Raleigh, NC |
| 27 | Sat Feb 21 | atSyracuse | W77-64 | 21-6 | .778 | #16 | ABC | JMA Wireless Dome · Syracuse, NY |
| 28 | Mon Feb 23 | vs24Louisville | W77-74 | 22-6 | .786 | #18 | ESPN | Dean E. Smith Center · Chapel Hill, NC |
| 29 | Sat Feb 28 | vsVirginia Tech | W89-82 | 23-6 | .793 | #18 | ESPN2 | Dean E. Smith Center · Chapel Hill, NC |
| 30 | Tue Mar 3 | vsClemson | W67-63 | 24-6 | .800 | #17 | ESPN | Dean E. Smith Center · Chapel Hill, NC |
| 31 | Sat Mar 7 | at1Duke | L61-76 | 24-7 | .774 | #17 | ESPN | Cameron Indoor Stadium · Durham, NC |
| 32 | Thu Mar 12 | vsClemson | L79-80 | 24-8 | .750 | #19 | ESPN | Dean E. Smith Center · Chapel Hill, NC |
| R1 | Thu Mar 19 | vs11VCU | L78-82 (OT) | 24-9 | .727 | #6 | TNT | Bon Secours Wellness Arena · Greenville, SC |
