| 1 | Wed Nov 6 | vs Notre Dame | W76-65 | 1-0 | 1.000 | #9 | ACC Network | Dean E. Smith Center · Chapel Hill, NC |
| 2 | Fri Nov 8 | atUNC Wilmington | W78-62 | 2-0 | 1.000 | #9 | | Trask Coliseum · Wilmington, NC |
| 3 | Fri Nov 15 | vsGardner-Webb | W77-61 | 3-0 | 1.000 | #6 | ACC Network | Dean E. Smith Center · Chapel Hill, NC |
| 4 | Wed Nov 20 | vsElon | W75-61 | 4-0 | 1.000 | - | | Dean E. Smith Center · Chapel Hill, NC |
| 5 | Wed Nov 27 | vsAlabama | W76-67 | 5-0 | 1.000 | - | ESPN | Dean E. Smith Center · Chapel Hill, NC |
| 6 | Thu Nov 28 | atMichigan | L64-73 | 5-1 | .833 | - | ESPN | Crisler Center · Ann Arbor, MI |
| 7 | Fri Nov 29 | vsOregon | W78-74 | 6-1 | .857 | - | ESPN | Dean E. Smith Center · Chapel Hill, NC |
| 8 | Wed Dec 4 | vsOhio State | L49-74 | 6-2 | .750 | - | ESPN | Dean E. Smith Center · Chapel Hill, NC |
| 9 | Sun Dec 8 | at5Virginia | L47-56 | 6-3 | .667 | #7 | ACC Network | John Paul Jones Arena · Charlottesville, VA |
| 10 | Sun Dec 15 | vsWofford | L64-68 | 6-4 | .600 | #17 | ACC Network | Dean E. Smith Center · Chapel Hill, NC |
| 11 | Wed Dec 18 | at2Gonzaga | L81-94 | 6-5 | .545 | - | ESPN2 | McCarthey Athletic Center · Spokane, WA |
| 12 | Sat Dec 21 | vsUCLA | W74-64 | 7-5 | .583 | - | CBS | T-Mobile Arena · Las Vegas, NV |
| 13 | Mon Dec 30 | vsYale | W70-67 | 8-5 | .615 | - | ACC Network | Dean E. Smith Center · Chapel Hill, NC |
| 14 | Sat Jan 4 | vsGeorgia Tech | L83-96 | 8-6 | .571 | - | ACC Network | Dean E. Smith Center · Chapel Hill, NC |
| 15 | Wed Jan 8 | vsPitt | L65-73 | 8-7 | .533 | - | ACC Network | Dean E. Smith Center · Chapel Hill, NC |
| 16 | Sat Jan 11 | vsClemson | L76-79 (OT) | 8-8 | .500 | - | | Dean E. Smith Center · Chapel Hill, NC |
| 17 | Sat Jan 18 | atPitt | L52-66 | 8-9 | .471 | - | ESPN | Petersen Events Center · Pittsburgh, PA |
| 18 | Wed Jan 22 | atVirginia Tech | L77-79 (2OT) | 8-10 | .444 | - | ACC Network | Cassell Coliseum · Blacksburg, VA |
| 19 | Sat Jan 25 | vsMiami | W94-71 | 9-10 | .474 | - | ESPN2 | Dean E. Smith Center · Chapel Hill, NC |
| 20 | Mon Jan 27 | atNC State | W75-65 | 10-10 | .500 | - | ESPN | PNC Arena · Raleigh, NC |
| 21 | Sat Feb 1 | vsBoston College | L70-71 | 10-11 | .476 | - | ACC Network | Dean E. Smith Center · Chapel Hill, NC |
| 22 | Mon Feb 3 | at8Florida St | L59-65 | 10-12 | .455 | - | ESPN | Donald L. Tucker Center · Tallahassee, FL |
| 23 | Sat Feb 8 | vs7Duke | L96-98 (OT) | 10-13 | .435 | - | ESPN | Dean E. Smith Center · Chapel Hill, NC |
| 24 | Tue Feb 11 | atWake Forest | L57-74 | 10-14 | .417 | - | ACC Network | Lawrence Joel Veterans Memorial Coliseum · Winston-Salem, NC |
| 25 | Sat Feb 15 | vsVirginia | L62-64 | 10-15 | .400 | - | ESPN | Dean E. Smith Center · Chapel Hill, NC |
| 26 | Mon Feb 17 | atNotre Dame | L76-77 | 10-16 | .385 | - | ESPN | Purcell Pavilion · South Bend, IN |
| 27 | Sat Feb 22 | at11Louisville | L55-72 | 10-17 | .370 | - | ESPN | KFC Yum! Center · Louisville, KY |
| 28 | Tue Feb 25 | vsNC State | W85-79 | 11-17 | .393 | - | ESPN | Dean E. Smith Center · Chapel Hill, NC |
| 29 | Sat Feb 29 | atSyracuse | W92-79 | 12-17 | .414 | - | ESPN | JMA Wireless Dome · Syracuse, NY |
| 30 | Tue Mar 3 | vsWake Forest | W93-83 | 13-17 | .433 | - | ACC Network | Dean E. Smith Center · Chapel Hill, NC |
| 31 | Sat Mar 7 | at12Duke | L76-89 | 13-18 | .419 | - | ESPN | Cameron Indoor Stadium · Durham, NC |
| 32 | Tue Mar 10 | atVirginia Tech | W78-56 | 14-18 | .438 | - | ACC Network | Greensboro Coliseum · Greensboro, NC |
| 33 | Wed Mar 11 | atSyracuse | L53-81 | 14-19 | .424 | - | ESPN2 | Greensboro Coliseum · Greensboro, NC |
