| 1 | Tue Nov 9 | at Richmond | L60-70 | 0-1 | .000 | - | | Robins Center · Richmond, VA |
| 2 | Sat Nov 13 | at #12Memphis | L51-90 | 0-2 | .000 | - | | FedExForum · Memphis, TN |
| 3 | Tue Nov 16 | at Iowa | L69-86 | 0-3 | .000 | - | BTN | Carver-Hawkeye Arena · Iowa City, IA |
| 4 | Sat Nov 20 | at Alabama St | L74-80 (OT) | 0-4 | .000 | - | | Dunn-Oliver Acadome · Montgomery, AL |
| 5 | Tue Nov 23 | vs TBD | W110-32 | 1-4 | .200 | - | | McDougald-McLendon Arena · Durham, NC |
| 6 | Sat Nov 27 | vsTBD | W96-56 | 2-4 | .333 | - | | McDougald-McLendon Arena · Durham, NC |
| 7 | Mon Nov 29 | at Gardner-Webb | L58-83 | 2-5 | .286 | - | | Paul Porter Arena · Boiling Springs, NC |
| 8 | Wed Dec 1 | at SC Upstate | W67-65 | 3-5 | .375 | - | | G.B. Hodge Center · Spartanburg, SC |
| 9 | Sat Dec 4 | at UNC Asheville | L66-82 | 3-6 | .333 | - | | Kimmel Arena · Asheville, NC |
| 10 | Mon Dec 6 | at The Citadel | L67-80 | 3-7 | .300 | - | | McAlister Field House · Charleston, SC |
| 11 | Thu Dec 9 | vsTBD | W102-50 | 4-7 | .364 | - | | McDougald-McLendon Arena · Durham, NC |
| 12 | Wed Dec 15 | vsGardner-Webb | W72-71 | 5-7 | .417 | - | | McDougald-McLendon Arena · Durham, NC |
| 13 | Sat Dec 18 | at Delaware St | W86-53 | 6-7 | .462 | - | | Memorial Hall (Dover, DE) · Dover, DE |
| 14 | Tue Dec 21 | at UTEP | L61-70 | 6-8 | .429 | - | | Don Haskins Center · El Paso, TX |
| 15 | Wed Dec 22 | vs Sam Houston | L51-68 | 6-9 | .400 | - | | McDougald-McLendon Arena · Durham, NC |
| 18 | Mon Jan 10 | vs Coppin St | PPD | 16-15 | .516 | - | | McDougald-McLendon Arena · Durham, NC |
| 19 | Sat Jan 15 | at SC State | PPD | 16-15 | .516 | - | | S-H-M Memorial Center · Orangeburg, SC |
| 20 | Sat Jan 22 | atDelaware St | W73-49 | 7-9 | .438 | - | | Memorial Hall (Dover, DE) · Dover, DE |
| 21 | Mon Jan 24 | at MD-Eastern | W75-63 | 8-9 | .471 | - | | Hytche Athletic Center · Princess Anne, MD |
| 22 | Sat Jan 29 | vs Howard | L74-75 (OT) | 8-10 | .444 | - | | McDougald-McLendon Arena · Durham, NC |
| 23 | Mon Jan 31 | vs Norfolk St | W70-67 | 9-10 | .474 | - | ESPNU | McDougald-McLendon Arena · Durham, NC |
| 24 | Sat Feb 5 | vsCoppin St | W69-68 | 10-10 | .500 | - | | McDougald-McLendon Arena · Durham, NC |
| 25 | Mon Feb 7 | atSC State | L68-74 | 10-11 | .476 | - | | S-H-M Memorial Center · Orangeburg, SC |
| 26 | Thu Feb 10 | vsTBD | W115-43 | 11-11 | .500 | - | | McDougald-McLendon Arena · Durham, NC |
| 27 | Sat Feb 12 | at Morgan St | W74-64 | 12-11 | .522 | - | | Hill Field House · Baltimore, MD |
| 28 | Mon Feb 14 | atCoppin St | W77-74 | 13-11 | .542 | - | ESPNU | Physical Education Complex · Baltimore, MD |
| 29 | Sat Feb 19 | vsDelaware St | W84-79 (OT) | 14-11 | .560 | - | | McDougald-McLendon Arena · Durham, NC |
| 30 | Mon Feb 21 | vsMD-Eastern | L66-79 | 14-12 | .538 | - | | McDougald-McLendon Arena · Durham, NC |
| 31 | Sat Feb 26 | atHoward | L67-77 | 14-13 | .519 | - | | Burr Gymnasium · Washington, D.C. |
| 32 | Mon Feb 28 | atNorfolk St | L46-75 | 14-14 | .500 | - | | Joseph G. Echols Hall · Norfolk, VA |
| 33 | Thu Mar 3 | vsSC State | W67-62 | 15-14 | .517 | - | | McDougald-McLendon Arena · Durham, NC |
| 34 | Thu Mar 10 | vsMD-Eastern | W68-56 | 16-14 | .533 | - | | McDougald-McLendon Arena · Durham, NC |
| 35 | Fri Mar 11 | vsCoppin St | L73-79 | 16-15 | .516 | - | | McDougald-McLendon Arena · Durham, NC |
