| 1 | Mon Nov 6 | at #1Kansas | L56-99 | 0-1 | .000 | - | | Allen Fieldhouse · Lawrence, KS |
| 2 | Thu Nov 9 | vs TBD | W107-54 | 1-1 | .500 | - | | McDougald-McLendon Arena · Durham, NC |
| 3 | Sun Nov 12 | at Georgia | L54-64 | 1-2 | .333 | - | | Stegeman Coliseum · Athens, GA |
| 4 | Tue Nov 14 | vsTBD | W113-50 | 2-2 | .500 | - | | McDougald-McLendon Arena · Durham, NC |
| 5 | Sat Nov 18 | at Longwood | L66-73 | 2-3 | .400 | - | | Willett Hall · Farmville, VA |
| 6 | Mon Nov 20 | at Campbell | W78-75 (OT) | 3-3 | .500 | - | | John W. Pope Jr. Convocation Center · Buies Creek, NC |
| 7 | Tue Nov 21 | at The Citadel | L61-67 | 3-4 | .429 | - | | McAlister Field House · Charleston, SC |
| 8 | Sun Nov 26 | at Coast Car | W70-58 | 4-4 | .500 | - | | The HTC Center · Conway, SC |
| 9 | Sat Dec 2 | vs SC Upstate | L82-85 | 4-5 | .444 | - | | McDougald-McLendon Arena · Durham, NC |
| 10 | Tue Dec 5 | at Virginia | L47-77 | 4-6 | .400 | - | | John Paul Jones Arena · Charlottesville, VA |
| 11 | Sat Dec 9 | at Radford | L74-82 | 4-7 | .364 | - | | Donald N. Dedmon Center · Radford, VA |
| 12 | Tue Dec 12 | at NC A&T | W67-62 | 5-7 | .417 | - | | Corbett Sports Center · Greensboro, NC |
| 13 | Fri Dec 15 | vsTBD | W102-50 | 6-7 | .462 | - | | McDougald-McLendon Arena · Durham, NC |
| 14 | Wed Dec 20 | vsLongwood | W79-70 | 7-7 | .500 | - | | McDougald-McLendon Arena · Durham, NC |
| 15 | Wed Jan 3 | vsTBD | W112-70 | 8-7 | .533 | - | | McDougald-McLendon Arena · Durham, NC |
| 16 | Sat Jan 6 | vs Howard | W73-54 | 9-7 | .563 | - | ESPNU | McDougald-McLendon Arena · Durham, NC |
| 17 | Mon Jan 8 | vs Norfolk St | W60-58 | 10-7 | .588 | - | | McDougald-McLendon Arena · Durham, NC |
| 18 | Sat Jan 20 | at SC State | L68-71 | 10-8 | .556 | - | | S-H-M Memorial Center · Orangeburg, SC |
| 19 | Sat Jan 27 | at MD-Eastern | W65-57 | 11-8 | .579 | - | | Hytche Athletic Center · Princess Anne, MD |
| 20 | Mon Jan 29 | at Delaware St | W69-66 | 12-8 | .600 | - | | Memorial Hall (Dover, DE) · Dover, DE |
| 21 | Sat Feb 3 | vs Coppin St | W77-46 | 13-8 | .619 | - | | McDougald-McLendon Arena · Durham, NC |
| 22 | Mon Feb 5 | vs Morgan St | L72-79 (OT) | 13-9 | .591 | - | | McDougald-McLendon Arena · Durham, NC |
| 23 | Sat Feb 17 | atHoward | L82-90 | 13-10 | .565 | - | | Burr Gymnasium · Washington, D.C. |
| 24 | Mon Feb 19 | atNorfolk St | L74-80 | 13-11 | .542 | - | ESPNU | Joseph G. Echols Hall · Norfolk, VA |
| 25 | Sat Feb 24 | vsMD-Eastern | W88-55 | 14-11 | .560 | - | | McDougald-McLendon Arena · Durham, NC |
| 26 | Mon Feb 26 | vsDelaware St | W93-81 | 15-11 | .577 | - | | McDougald-McLendon Arena · Durham, NC |
| 27 | Sat Mar 2 | atCoppin St | W83-58 | 16-11 | .593 | - | | Physical Education Complex · Baltimore, MD |
| 28 | Mon Mar 4 | atMorgan St | L79-88 | 16-12 | .571 | - | | Hill Field House · Baltimore, MD |
| 29 | Thu Mar 7 | vsSC State | W79-68 | 17-12 | .586 | - | | McDougald-McLendon Arena · Durham, NC |
| 30 | Wed Mar 13 | vsMD-Eastern | W87-81 | 18-12 | .600 | - | | McDougald-McLendon Arena · Durham, NC |
| 31 | Fri Mar 15 | vsDelaware St | L58-71 | 18-13 | .581 | - | | McDougald-McLendon Arena · Durham, NC |
