| 1 | Tue Nov 9 | vs TBD | W118-66 | 1-0 | 1.000 | - | | Timmons Arena · Greenville, SC |
| 2 | Fri Nov 12 | at Louisville | W80-72 (OT) | 2-0 | 1.000 | - | | KFC Yum! Center · Louisville, KY |
| 3 | Mon Nov 15 | at Belmont | L89-95 (OT) | 2-1 | .667 | - | | Curb Event Center Arena · Nashville, TN |
| 4 | Fri Nov 19 | vs Radford | W81-64 | 3-1 | .750 | - | | Timmons Arena · Greenville, SC |
| 5 | Sun Nov 21 | vs Navy | L66-77 | 3-2 | .600 | - | | Timmons Arena · Greenville, SC |
| 6 | Sat Nov 27 | at SC Upstate | W87-77 | 4-2 | .667 | - | | G.B. Hodge Center · Spartanburg, SC |
| 7 | Tue Nov 30 | at High Point | W74-70 (2OT) | 5-2 | .714 | - | | Nido and Mariana Qubein Arena · High Point, NC |
| 8 | Fri Dec 3 | vs Charleston | W91-88 (OT) | 6-2 | .750 | - | | Timmons Arena · Greenville, SC |
| 9 | Tue Dec 7 | at Winthrop | L80-85 | 6-3 | .667 | - | | Winthrop Coliseum · Rock Hill, SC |
| 10 | Fri Dec 10 | vs Appalachian St | W73-65 | 7-3 | .700 | - | | Timmons Arena · Greenville, SC |
| 11 | Tue Dec 14 | at UNC | L61-74 | 7-4 | .636 | - | ESPN2 | Dean E. Smith Center · Chapel Hill, NC |
| 12 | Fri Dec 17 | at Mississippi St | L66-69 | 7-5 | .583 | - | SEC Network | Humphrey Coliseum · Starkville, MS |
| 13 | Tue Dec 21 | vs Presbyterian | W75-61 | 8-5 | .615 | - | | Timmons Arena · Greenville, SC |
| 14 | Wed Dec 29 | vs Samford | W81-49 | 9-5 | .643 | - | | Timmons Arena · Greenville, SC |
| 15 | Sat Jan 1 | at VMI | L67-76 | 9-6 | .600 | - | | Cameron Hall · Lexington, VA |
| 16 | Wed Jan 5 | at UNC Greensboro | W58-54 | 10-6 | .625 | - | ESPNEWS | Greensboro Coliseum · Greensboro, NC |
| 17 | Sat Jan 8 | vs Mercer | W81-66 | 11-6 | .647 | - | | Timmons Arena · Greenville, SC |
| 18 | Wed Jan 12 | vs ETSU | W78-69 | 12-6 | .667 | - | | Timmons Arena · Greenville, SC |
| 19 | Sat Jan 15 | at Chattanooga | L69-71 | 12-7 | .632 | - | CBS | McKenzie Arena · Chattanooga, TN |
| 20 | Wed Jan 19 | vs W Carolina | W88-50 | 13-7 | .650 | - | | Timmons Arena · Greenville, SC |
| 21 | Sat Jan 22 | at Wofford | W75-50 | 14-7 | .667 | - | | Jerry Richardson Indoor Stadium · Spartanburg, SC |
| 22 | Wed Jan 26 | vsVMI | W79-64 | 15-7 | .682 | - | | Timmons Arena · Greenville, SC |
| 23 | Sat Jan 29 | atMercer | W80-50 | 16-7 | .696 | - | CBS | Hawkins Arena · Macon, GA |
| 24 | Wed Feb 2 | vs The Citadel | W102-83 | 17-7 | .708 | - | | Timmons Arena · Greenville, SC |
| 25 | Sat Feb 5 | vsUNC Greensboro | L56-58 | 17-8 | .680 | - | | Timmons Arena · Greenville, SC |
| 26 | Mon Feb 7 | atETSU | L71-75 | 17-9 | .654 | - | ESPNU | Freedom Hall Civic Center · Johnson City, TN |
| 27 | Sat Feb 12 | vsChattanooga | L58-64 | 17-10 | .630 | - | | Timmons Arena · Greenville, SC |
| 28 | Wed Feb 16 | atW Carolina | W103-85 | 18-10 | .643 | - | | Ramsey Regional Activity Center · Cullowhee, NC |
| 29 | Sat Feb 19 | vsWofford | W70-69 | 19-10 | .655 | - | | Timmons Arena · Greenville, SC |
| 30 | Wed Feb 23 | atSamford | L75-83 | 19-11 | .633 | - | | Pete Hanna Center · Homewood, AL |
| 31 | Sat Feb 26 | atThe Citadel | W94-59 | 20-11 | .645 | - | | McAlister Field House · Charleston, SC |
| 32 | Sat Mar 5 | vsMercer | W80-66 | 21-11 | .656 | - | | Timmons Arena · Greenville, SC |
| 33 | Sun Mar 6 | vsSamford | W71-68 | 22-11 | .667 | - | ESPNU | Timmons Arena · Greenville, SC |
| 34 | Mon Mar 7 | atChattanooga | L63-64 (OT) | 22-12 | .647 | - | ESPN | McKenzie Arena · Chattanooga, TN |
