| 1 | Mon Nov 4 | vs TBD | W104-46 | - | 1-0 | 1.000 | - | | Bon Secours Wellness Arena · Greenville, SC |
| 2 | Fri Nov 8 | atBelmont | W76-74 | - | 2-0 | 1.000 | - | ESPN+ | Curb Event Center Arena · Nashville, TN |
| 3 | Mon Nov 11 | vsJacksonville | W78-69 | - | 3-0 | 1.000 | - | ESPN+ | Bon Secours Wellness Arena · Greenville, SC |
| 4 | Fri Nov 15 | vsTulane | W75-67 | - | 4-0 | 1.000 | - | ESPN+ | Bon Secours Wellness Arena · Greenville, SC |
| 5 | Wed Nov 20 | vsTBD | W124-48 | - | 5-0 | 1.000 | - | | Timmons Arena · Greenville, SC |
| 6 | Sat Nov 23 | atCharleston So | W67-46 | - | 6-0 | 1.000 | - | ESPN+ | Buccaneer Fieldhouse · Charleston, SC |
| 7 | Tue Nov 26 | atSeattle U | W61-56 | - | 7-0 | 1.000 | - | ESPNU | T-Mobile Arena · Las Vegas, NV |
| 8 | Sat Nov 30 | at1Kansas | L51-86 | - | 7-1 | .875 | - | ESPN+ | Allen Fieldhouse · Lawrence, KS |
| 9 | Wed Dec 4 | atFGCU | W76-73 | - | 8-1 | .889 | - | ESPN+ | Alico Arena · Fort Myers, FL |
| 10 | Sat Dec 7 | vsPrinceton | W69-63 | - | 9-1 | .900 | - | ESPN+ | Bon Secours Wellness Arena · Greenville, SC |
| 11 | Sat Dec 14 | vsSC State | W68-64 | - | 10-1 | .909 | - | ESPN+ | Bon Secours Wellness Arena · Greenville, SC |
| 12 | Wed Dec 18 | vsTBD | W100-75 | - | 11-1 | .917 | - | | Timmons Arena · Greenville, SC |
| 13 | Sat Dec 21 | atHarvard | W77-63 | - | 12-1 | .923 | - | ESPN+ | Lavietes Pavilion · Cambridge, MA |
| 14 | Wed Jan 1 | atW Carolina | W90-61 | - | 13-1 | .929 | - | ESPN+ | Ramsey Regional Activity Center · Cullowhee, NC |
| 15 | Sat Jan 4 | atUNC Greensboro | L67-84 | - | 13-2 | .867 | - | ESPN+ | Greensboro Coliseum · Greensboro, NC |
| 16 | Wed Jan 8 | atThe Citadel | W67-63 (OT) | - | 14-2 | .875 | - | ESPN+ | McAlister Field House · Charleston, SC |
| 17 | Mon Jan 13 | vsWofford | L62-81 | - | 14-3 | .824 | - | ESPN+ | Bon Secours Wellness Arena · Greenville, SC |
| 18 | Wed Jan 15 | vsETSU | W73-70 | - | 15-3 | .833 | - | ESPN+ | Bon Secours Wellness Arena · Greenville, SC |
| 19 | Sat Jan 18 | vsChattanooga | L71-75 | - | 15-4 | .789 | - | ESPN+ | Bon Secours Wellness Arena · Greenville, SC |
| 20 | Wed Jan 22 | atVMI | L82-91 | - | 15-5 | .750 | - | ESPN+ | Cameron Hall · Lexington, VA |
| 21 | Sat Jan 25 | atMercer | W79-74 | - | 16-5 | .762 | - | ESPN+ | Hawkins Arena · Macon, GA |
| 22 | Wed Jan 29 | vsSamford | W72-70 | - | 17-5 | .773 | - | CBS Sports Network | Bon Secours Wellness Arena · Greenville, SC |
| 23 | Sun Feb 2 | atETSU | L69-72 | - | 17-6 | .739 | - | CBS Sports Network | Freedom Hall Civic Center · Johnson City, TN |
| 24 | Wed Feb 5 | vsW Carolina | W84-75 (OT) | - | 18-6 | .750 | - | ESPN+ | Bon Secours Wellness Arena · Greenville, SC |
| 25 | Sat Feb 8 | atChattanooga | L72-85 | - | 18-7 | .720 | - | ESPN+ | McKenzie Arena · Chattanooga, TN |
| 26 | Wed Feb 12 | vsMercer | W96-72 | - | 19-7 | .731 | - | ESPN+ | Bon Secours Wellness Arena · Greenville, SC |
| 27 | Sat Feb 15 | vsUNC Greensboro | L50-58 | - | 19-8 | .704 | - | ESPN+ | Bon Secours Wellness Arena · Greenville, SC |
| 28 | Wed Feb 19 | atSamford | W80-72 | - | 20-8 | .714 | - | ESPN+ | Pete Hanna Center · Homewood, AL |
| 29 | Sat Feb 22 | vsVMI | W75-71 | - | 21-8 | .724 | - | ESPN+ | Bon Secours Wellness Arena · Greenville, SC |
| 30 | Wed Feb 26 | vsThe Citadel | W85-42 | - | 22-8 | .733 | - | ESPN+ | Bon Secours Wellness Arena · Greenville, SC |
| 31 | Sat Mar 1 | atWofford | W78-75 | - | 23-8 | .742 | - | ESPN+ | Jerry Richardson Indoor Stadium · Spartanburg, SC |
| 32 | Sat Mar 8 | atSamford | W95-78 | - | 24-8 | .750 | - | ESPN+ | Pete Hanna Center · Homewood, AL |
| 33 | Sun Mar 9 | atChattanooga | W80-77 (OT) | - | 25-8 | .758 | - | ESPNU | McKenzie Arena · Chattanooga, TN |
| 34 | Mon Mar 10 | vsWofford | L85-92 | - | 25-9 | .735 | - | ESPN | Timmons Arena · Greenville, SC |
| 35 | Wed Mar 19 | atNorth Texas | L64-75 | - | 25-10 | .714 | - | ESPN+ | The Super Pit · Denton, TX |
