| 1 | Wed Nov 25 | vs TBD | W95-62 | 1-0 | 1.000 | - | | Timmons Arena · Greenville, SC |
| 2 | Sat Nov 28 | vs SC Upstate | W91-63 | 2-0 | 1.000 | - | | Timmons Arena · Greenville, SC |
| 3 | Wed Dec 2 | vsTBD | W89-49 | 3-0 | 1.000 | - | | Timmons Arena · Greenville, SC |
| 4 | Sat Dec 5 | at Charleston | W81-57 | 4-0 | 1.000 | - | | TD Arena · Charleston, SC |
| 5 | Wed Dec 9 | at Cincinnati | L73-78 | 4-1 | .800 | - | | Fifth Third Arena · Cincinnati, OH |
| 6 | Sat Dec 12 | vsTBD | W86-61 | 5-1 | .833 | - | | Timmons Arena · Greenville, SC |
| 7 | Tue Dec 15 | at Alabama | L80-83 | 5-2 | .714 | - | SEC Network | Coleman Coliseum · Tuscaloosa, AL |
| 8 | Sat Dec 19 | at Winthrop | L71-87 | 5-3 | .625 | - | | Winthrop Coliseum · Rock Hill, SC |
| 9 | Mon Dec 21 | vs SC State | W118-52 | 6-3 | .667 | - | | Timmons Arena · Greenville, SC |
| 10 | Wed Dec 30 | at Chattanooga | W77-73 | 7-3 | .700 | - | | McKenzie Arena · Chattanooga, TN |
| 11 | Sat Jan 2 | vs Mercer | W83-80 | 8-3 | .727 | - | | Timmons Arena · Greenville, SC |
| 12 | Sat Jan 9 | vs VMI | PPD | 16-9 | .640 | - | | Timmons Arena · Greenville, SC |
| 13 | Wed Jan 13 | at The Citadel | W94-88 | 9-3 | .750 | - | | McAlister Field House · Charleston, SC |
| 14 | Sat Jan 16 | vs ETSU | W78-66 | 10-3 | .769 | - | ESPNU | Timmons Arena · Greenville, SC |
| 15 | Wed Jan 20 | atVMI | L73-74 | 10-4 | .714 | - | | Cameron Hall · Lexington, VA |
| 16 | Sat Jan 23 | atETSU | L62-71 | 10-5 | .667 | - | | Freedom Hall Civic Center · Johnson City, TN |
| 17 | Mon Jan 25 | vs UNC Greensboro | PPD | 16-9 | .640 | - | | Timmons Arena · Greenville, SC |
| 18 | Sat Jan 30 | at W Carolina | W75-69 | 11-5 | .688 | - | | Ramsey Regional Activity Center · Cullowhee, NC |
| 19 | Wed Feb 3 | at Samford | PPD | 16-9 | .640 | - | | Pete Hanna Center · Homewood, AL |
| 20 | Sat Feb 6 | vs Wofford | L67-75 | 11-6 | .647 | - | | Timmons Arena · Greenville, SC |
| 21 | Mon Feb 8 | vsUNC Greensboro | W68-49 | 12-6 | .667 | - | ESPNU | Timmons Arena · Greenville, SC |
| 22 | Wed Feb 10 | atUNC Greensboro | L58-64 | 12-7 | .632 | - | ESPNU | Greensboro Coliseum · Greensboro, NC |
| 23 | Sat Feb 13 | vsW Carolina | W88-70 | 13-7 | .650 | - | | Timmons Arena · Greenville, SC |
| 24 | Wed Feb 17 | vsSamford | W78-64 | 14-7 | .667 | - | | Timmons Arena · Greenville, SC |
| 25 | Sat Feb 20 | atMercer | W70-60 | 15-7 | .682 | - | | Hawkins Arena · Macon, GA |
| 27 | Wed Feb 24 | vsThe Citadel | W72-63 | 16-7 | .696 | - | | Timmons Arena · Greenville, SC |
| 28 | Sat Feb 27 | atWofford | L73-74 | 16-8 | .667 | - | | Jerry Richardson Indoor Stadium · Spartanburg, SC |
| 29 | Sat Mar 6 | vsVMI | L90-91 (OT) | 16-9 | .640 | - | | Timmons Arena · Greenville, SC |
