| 1 | Mon Nov 3 | at High Point | L71-97 | 0-1 | .000 | - | YouTube | Nido and Mariana Qubein Arena · High Point, NC |
| 2 | Fri Nov 7 | vsTroy | L61-64 | 0-2 | .000 | - | ESPN+ | Timmons Arena · Greenville, SC |
| 3 | Mon Nov 10 | vsTBD | W89-59 | 1-2 | .333 | - | ESPN+ | Timmons Arena · Greenville, SC |
| 4 | Fri Nov 14 | atNorthern Iowa | L54-70 | 1-3 | .250 | - | ESPN+ | McLeod Center · Cedar Falls, IA |
| 5 | Wed Nov 19 | vsTBD | W79-44 | 2-3 | .400 | - | ESPN+ | Timmons Arena · Greenville, SC |
| 6 | Sun Nov 23 | vsQueens | W90-79 | 3-3 | .500 | - | ESPN+ | Timmons Arena · Greenville, SC |
| 7 | Thu Nov 27 | vsRichmond | W73-72 | 4-3 | .571 | - | ESPN2 | Timmons Arena · Greenville, SC |
| 8 | Fri Nov 28 | atIllinois St | L65-72 | 4-4 | .500 | - | ESPN2 | Redbird Arena · Normal, IL |
| 9 | Wed Dec 3 | atElon | W97-88 | 5-4 | .556 | - | | Schar Center · Elon, NC |
| 10 | Sat Dec 6 | vsHarvard | W79-69 | 6-4 | .600 | - | ESPN+ | Timmons Arena · Greenville, SC |
| 11 | Tue Dec 9 | vsTBD | W105-57 | 7-4 | .636 | - | ESPN+ | Timmons Arena · Greenville, SC |
| 12 | Thu Dec 18 | atManhattan | W75-68 | 8-4 | .667 | - | ESPN+ | Draddy Gymnasium · Riverdale, NY |
| 13 | Sun Dec 21 | vsCharleston So | W84-76 | 9-4 | .692 | - | ESPN+ | Timmons Arena · Greenville, SC |
| 14 | Wed Dec 31 | vsMercer | W74-72 | 10-4 | .714 | - | ESPN+ | Timmons Arena · Greenville, SC |
| 15 | Sat Jan 3 | vsW Carolina | L77-80 (OT) | 10-5 | .667 | - | ESPN+ | Timmons Arena · Greenville, SC |
| 16 | Wed Jan 7 | atChattanooga | W78-67 | 11-5 | .688 | - | CBSSN | McKenzie Arena · Chattanooga, TN |
| 17 | Sat Jan 10 | vsVMI | W69-48 | 12-5 | .706 | - | ESPN+ | Timmons Arena · Greenville, SC |
| 18 | Wed Jan 14 | atSamford | W77-73 | 13-5 | .722 | - | ESPN+ | Pete Hanna Center · Homewood, AL |
| 19 | Sat Jan 17 | vsWofford | L70-74 | 13-6 | .684 | - | ESPN+ | Timmons Arena · Greenville, SC |
| 20 | Wed Jan 21 | atThe Citadel | L75-77 (OT) | 13-7 | .650 | - | ESPN+ | McAlister Field House · Charleston, SC |
| 21 | Fri Jan 23 | atUNC Greensboro | W89-66 | 14-7 | .667 | - | ESPN+ | Greensboro Coliseum · Greensboro, NC |
| 22 | Thu Jan 29 | vsSamford | W78-73 | 15-7 | .682 | - | CBSSN | Timmons Arena · Greenville, SC |
| 23 | Sun Feb 1 | vsChattanooga | W75-70 | 16-7 | .696 | - | ESPN2 | Timmons Arena · Greenville, SC |
| 24 | Wed Feb 4 | atETSU | L71-75 (OT) | 16-8 | .667 | - | ESPN+ | Freedom Hall Civic Center · Johnson City, TN |
| 25 | Sun Feb 8 | vsUNC Greensboro | L64-67 | 16-9 | .640 | - | ESPN2 | Timmons Arena · Greenville, SC |
| 26 | Wed Feb 11 | atMercer | L64-69 | 16-10 | .615 | - | ESPN+ | Hawkins Arena · Macon, GA |
| 27 | Sat Feb 14 | atVMI | W90-72 | 17-10 | .630 | - | ESPN+ | Cameron Hall · Lexington, VA |
| 28 | Wed Feb 18 | vsETSU | L69-78 | 17-11 | .607 | - | ESPN+ | Timmons Arena · Greenville, SC |
| 29 | Sat Feb 21 | atWofford | W76-67 | 18-11 | .621 | - | ESPN+ | Jerry Richardson Indoor Stadium · Spartanburg, SC |
| 30 | Wed Feb 25 | vsThe Citadel | W72-51 | 19-11 | .633 | - | ESPN+ | Timmons Arena · Greenville, SC |
| 31 | Sat Feb 28 | atW Carolina | L67-86 | 19-12 | .613 | - | ESPN+ | Ramsey Regional Activity Center · Cullowhee, NC |
