| 1 | Mon Nov 7 | vs TBD | W91-55 | - | 1-0 | 1.000 | - | | Timmons Arena · Greenville, SC |
| 2 | Fri Nov 11 | vsBelmont | W89-74 | -9 | 2-0 | 1.000 | - | | Timmons Arena · Greenville, SC |
| 3 | Thu Nov 17 | atPenn State | L68-73 | +2½ | 2-1 | .667 | - | ESPNU | TD Arena · Charleston, SC |
| 4 | Fri Nov 18 | atOld Dominion | L77-82 | -8 | 2-2 | .500 | - | ESPNU | TD Arena · Charleston, SC |
| 5 | Sun Nov 20 | atSouth Carolina | W79-60 | -7 | 3-2 | .600 | - | ESPNEWS | TD Arena · Charleston, SC |
| 6 | Fri Nov 25 | vsTBD | W102-74 | - | 4-2 | .667 | - | | Timmons Arena · Greenville, SC |
| 7 | Tue Nov 29 | atAppalachian St | W65-61 | -6½ | 5-2 | .714 | - | | Holmes Convocation Center · Boone, NC |
| 8 | Sat Dec 3 | vsSC State | W88-76 | -26 | 6-2 | .750 | - | | Timmons Arena · Greenville, SC |
| 9 | Tue Dec 6 | vsHigh Point | L82-85 | -12 | 6-3 | .667 | - | | Timmons Arena · Greenville, SC |
| 10 | Sat Dec 10 | vsWinthrop | W82-67 | -13½ | 7-3 | .700 | - | | Timmons Arena · Greenville, SC |
| 11 | Tue Dec 13 | atNC State | L73-92 | +6½ | 7-4 | .636 | - | ACC Network | Lenovo Center · Raleigh, NC |
| 12 | Sat Dec 17 | vsSF Austin | W72-70 | -6 | 8-4 | .667 | - | | Bon Secours Wellness Arena · Greenville, SC |
| 13 | Mon Dec 19 | vsTBD | W106-79 | - | 9-4 | .692 | - | | Timmons Arena · Greenville, SC |
| 14 | Thu Dec 29 | vsVMI | W85-62 | -19½ | 10-4 | .714 | - | | Timmons Arena · Greenville, SC |
| 15 | Sat Dec 31 | atW Carolina | L67-79 | -11½ | 10-5 | .667 | - | | Ramsey Regional Activity Center · Cullowhee, NC |
| 16 | Wed Jan 4 | vsThe Citadel | W97-72 | -15½ | 11-5 | .688 | - | | Timmons Arena · Greenville, SC |
| 17 | Sat Jan 7 | atETSU | W70-56 | -7½ | 12-5 | .706 | - | | Freedom Hall Civic Center · Johnson City, TN |
| 18 | Wed Jan 11 | atMercer | W84-66 | -6½ | 13-5 | .722 | - | | Hawkins Arena · Macon, GA |
| 19 | Sat Jan 14 | vsUNC Greensboro | L80-88 (OT) | -5½ | 13-6 | .684 | - | | Timmons Arena · Greenville, SC |
| 20 | Wed Jan 18 | atChattanooga | W77-69 | +1½ | 14-6 | .700 | - | | McKenzie Arena · Chattanooga, TN |
| 21 | Sun Jan 22 | atWofford | W96-82 | -5 | 15-6 | .714 | - | ESPNU | Jerry Richardson Indoor Stadium · Spartanburg, SC |
| 22 | Wed Jan 25 | vsSamford | W91-84 (OT) | -4½ | 16-6 | .727 | - | | Timmons Arena · Greenville, SC |
| 23 | Sun Jan 29 | atUNC Greensboro | W69-57 | -1½ | 17-6 | .739 | - | | Greensboro Coliseum · Greensboro, NC |
| 24 | Wed Feb 1 | vsChattanooga | W79-58 | -10½ | 18-6 | .750 | - | | Timmons Arena · Greenville, SC |
| 25 | Sat Feb 4 | vsWofford | W80-67 | -10½ | 19-6 | .760 | - | | Timmons Arena · Greenville, SC |
| 26 | Wed Feb 8 | atVMI | W94-63 | -17 | 20-6 | .769 | - | | Cameron Hall · Lexington, VA |
| 27 | Sat Feb 11 | vsW Carolina | W93-59 | -15 | 21-6 | .778 | - | | Timmons Arena · Greenville, SC |
| 28 | Wed Feb 15 | atThe Citadel | L65-69 | -16 | 21-7 | .750 | - | | McAlister Field House · Charleston, SC |
| 29 | Sun Feb 19 | vsETSU | W83-79 | -14 | 22-7 | .759 | - | ESPNU | Timmons Arena · Greenville, SC |
| 30 | Wed Feb 22 | vsMercer | W70-67 | -13 | 23-7 | .767 | - | | Timmons Arena · Greenville, SC |
| 31 | Sat Feb 25 | atSamford | W93-79 | -1 | 24-7 | .774 | - | CBS Sports Network | Pete Hanna Center · Homewood, AL |
| 32 | Sat Mar 4 | vsMercer | W73-58 | -10½ | 25-7 | .781 | - | | Timmons Arena · Greenville, SC |
| 33 | Sun Mar 5 | vsW Carolina | W83-80 (OT) | -12½ | 26-7 | .788 | - | ESPNU | Timmons Arena · Greenville, SC |
| 34 | Mon Mar 6 | vsChattanooga | W88-79 | -3 | 27-7 | .794 | - | ESPN | Timmons Arena · Greenville, SC |
| 35 | Thu Mar 16 | at4Virginia | W68-67 | +5½ | 28-7 | .800 | #13 | truTV | John Paul Jones Arena · Charlottesville, VA |
| 36 | Sat Mar 18 | at5SDSU | L52-75 | +4½ | 28-8 | .778 | #13 | CBS | Viejas Arena · San Diego, CA |
