| 1 | Mon Nov 6 | vs TBD | W84-68 | 1-0 | 1.000 | - | | Timmons Arena · Greenville, SC |
| 2 | Fri Nov 10 | vs Belmont | W99-76 | 2-0 | 1.000 | - | | Timmons Arena · Greenville, SC |
| 3 | Thu Nov 16 | at Liberty | L74-88 | 2-1 | .667 | - | | Liberty Arena · Lynchburg, VA |
| 4 | Fri Nov 17 | vs Coast Car | W89-80 | 3-1 | .750 | - | | Timmons Arena · Greenville, SC |
| 5 | Sun Nov 19 | vs Wyoming | L71-78 | 3-2 | .600 | - | ESPNU | Timmons Arena · Greenville, SC |
| 6 | Sat Nov 25 | at UAB | L86-92 | 3-3 | .500 | - | | Bartow Arena · Birmingham, AL |
| 7 | Tue Nov 28 | vs SC State | W86-78 | 4-3 | .571 | - | | Timmons Arena · Greenville, SC |
| 8 | Sat Dec 2 | at Princeton | L69-70 | 4-4 | .500 | - | | Jadwin Gymnasium · Princeton, NJ |
| 9 | Mon Dec 4 | at Arkansas | L83-97 | 4-5 | .444 | - | | Bud Walton Arena · Fayetteville, AR |
| 10 | Sat Dec 9 | vsTBD | W100-58 | 5-5 | .500 | - | | Timmons Arena · Greenville, SC |
| 11 | Thu Dec 14 | at Tulane | L110-117 (2OT) | 5-6 | .455 | - | | Devlin Fieldhouse · New Orleans, LA |
| 12 | Tue Dec 19 | vs Presbyterian | W76-61 | 6-6 | .500 | - | | Timmons Arena · Greenville, SC |
| 13 | Sat Dec 30 | vsTBD | L74-79 | 6-7 | .462 | - | | Timmons Arena · Greenville, SC |
| 14 | Wed Jan 3 | at UNC Greensboro | L68-79 | 6-8 | .429 | - | | Greensboro Coliseum · Greensboro, NC |
| 15 | Sat Jan 6 | at Chattanooga | L58-73 | 6-9 | .400 | - | | McKenzie Arena · Chattanooga, TN |
| 16 | Wed Jan 10 | vs The Citadel | W82-68 | 7-9 | .438 | - | | Timmons Arena · Greenville, SC |
| 17 | Sat Jan 13 | vs ETSU | W82-73 | 8-9 | .471 | - | | Timmons Arena · Greenville, SC |
| 18 | Wed Jan 17 | at VMI | W100-60 | 9-9 | .500 | - | | Cameron Hall · Lexington, VA |
| 19 | Sat Jan 20 | vs W Carolina | W65-62 | 10-9 | .526 | - | | Timmons Arena · Greenville, SC |
| 20 | Wed Jan 24 | vs Samford | W78-68 | 11-9 | .550 | - | | Timmons Arena · Greenville, SC |
| 21 | Sat Jan 27 | at Wofford | L67-77 | 11-10 | .524 | - | | Jerry Richardson Indoor Stadium · Spartanburg, SC |
| 22 | Wed Jan 31 | atThe Citadel | W82-79 (OT) | 12-10 | .545 | - | | McAlister Field House · Charleston, SC |
| 23 | Sun Feb 4 | vsUNC Greensboro | L87-89 | 12-11 | .522 | - | ESPNU | Timmons Arena · Greenville, SC |
| 24 | Wed Feb 7 | at Mercer | L69-78 | 12-12 | .500 | - | | Hawkins Arena · Macon, GA |
| 25 | Sat Feb 10 | atETSU | W65-63 | 13-12 | .520 | - | CBS | Freedom Hall Civic Center · Johnson City, TN |
| 26 | Wed Feb 14 | vsVMI | W75-62 | 14-12 | .538 | - | | Timmons Arena · Greenville, SC |
| 27 | Sun Feb 18 | vsChattanooga | W82-65 | 15-12 | .556 | - | CBS | Timmons Arena · Greenville, SC |
| 28 | Wed Feb 21 | atSamford | L72-74 | 15-13 | .536 | - | | Pete Hanna Center · Homewood, AL |
| 29 | Sat Feb 24 | vsWofford | W82-67 | 16-13 | .552 | - | | Timmons Arena · Greenville, SC |
| 30 | Wed Feb 28 | atW Carolina | L77-85 | 16-14 | .533 | - | ESPNU | Ramsey Regional Activity Center · Cullowhee, NC |
| 31 | Sat Mar 2 | vsMercer | L75-82 | 16-15 | .516 | - | | Timmons Arena · Greenville, SC |
| 32 | Sat Mar 9 | atW Carolina | W79-76 (OT) | 17-15 | .531 | - | | Ramsey Regional Activity Center · Cullowhee, NC |
| 33 | Sun Mar 10 | atSamford | L77-84 | 17-16 | .515 | - | ESPNU | Pete Hanna Center · Homewood, AL |
