| 1 | Tue Nov 5 | at Gardner-Webb | W70-63 | -3½ | 1-0 | 1.000 | - | | Paul Porter Arena · Boiling Springs, NC |
| 2 | Fri Nov 8 | vsLoyola Chicago | W87-63 | -4½ | 2-0 | 1.000 | - | | Timmons Arena · Greenville, SC |
| 3 | Tue Nov 12 | atCharleston So | W91-47 | -8½ | 3-0 | 1.000 | - | | Buccaneer Fieldhouse · Charleston, SC |
| 4 | Fri Nov 15 | vsTBD | W83-61 | - | 4-0 | 1.000 | - | | Timmons Arena · Greenville, SC |
| 5 | Tue Nov 19 | atAlabama | L73-81 | +3½ | 4-1 | .800 | - | | Coleman Coliseum · Tuscaloosa, AL |
| 6 | Fri Nov 22 | vsTBD | W90-45 | - | 5-1 | .833 | - | | Timmons Arena · Greenville, SC |
| 7 | Tue Nov 26 | atElon | W97-61 | -15½ | 6-1 | .857 | - | | Schar Center · Elon, NC |
| 8 | Wed Nov 27 | vsUT Arlington | W58-57 | -6 | 7-1 | .875 | - | | Schar Center · Elon, NC |
| 9 | Mon Dec 2 | atSouth Florida | L55-65 | -3½ | 7-2 | .778 | - | | Yuengling Center · Tampa, FL |
| 10 | Thu Dec 5 | at14Auburn | L78-81 (OT) | +12½ | 7-3 | .700 | - | SEC Network | Neville Arena · Auburn, AL |
| 11 | Sun Dec 8 | vsSC Upstate | W84-72 | -23½ | 8-3 | .727 | - | | Timmons Arena · Greenville, SC |
| 12 | Wed Dec 11 | vsTBD | W90-65 | - | 9-3 | .750 | - | | Timmons Arena · Greenville, SC |
| 13 | Sat Dec 14 | vsWinthrop | W80-73 | -9 | 10-3 | .769 | - | | Timmons Arena · Greenville, SC |
| 14 | Fri Dec 20 | atMercer | W64-62 | -9½ | 11-3 | .786 | - | | Hawkins Arena · Macon, GA |
| 15 | Wed Jan 1 | atVMI | W89-73 | -12½ | 12-3 | .800 | - | | Cameron Hall · Lexington, VA |
| 16 | Sat Jan 4 | vsETSU | W65-56 | -2½ | 13-3 | .813 | - | | Timmons Arena · Greenville, SC |
| 17 | Wed Jan 8 | atChattanooga | W73-66 | -6½ | 14-3 | .824 | - | | McKenzie Arena · Chattanooga, TN |
| 18 | Sat Jan 11 | vsUNC Greensboro | L73-86 | -5 | 14-4 | .778 | - | | Timmons Arena · Greenville, SC |
| 19 | Wed Jan 15 | vsW Carolina | W83-79 | -11½ | 15-4 | .789 | - | | Timmons Arena · Greenville, SC |
| 20 | Fri Jan 17 | atWofford | L52-66 | -3½ | 15-5 | .750 | - | ESPNU | Jerry Richardson Indoor Stadium · Spartanburg, SC |
| 21 | Wed Jan 22 | vsSamford | W101-78 | -16½ | 16-5 | .762 | - | | Timmons Arena · Greenville, SC |
| 22 | Sat Jan 25 | atThe Citadel | W78-54 | -13½ | 17-5 | .773 | - | | McAlister Field House · Charleston, SC |
| 23 | Wed Jan 29 | vsVMI | W74-72 (OT) | -16½ | 18-5 | .783 | - | | Timmons Arena · Greenville, SC |
| 24 | Wed Feb 5 | vsMercer | W79-57 | -11½ | 19-5 | .792 | - | | Timmons Arena · Greenville, SC |
| 25 | Sat Feb 8 | atW Carolina | W82-73 | -4½ | 20-5 | .800 | - | | Ramsey Regional Activity Center · Cullowhee, NC |
| 26 | Wed Feb 12 | atSamford | W86-71 | -12 | 21-5 | .808 | - | | Pete Hanna Center · Homewood, AL |
| 27 | Sat Feb 15 | vsChattanooga | W58-53 | -9½ | 22-5 | .815 | - | | Timmons Arena · Greenville, SC |
| 28 | Wed Feb 19 | atETSU | L66-75 | +5 | 22-6 | .786 | - | | Freedom Hall Civic Center · Johnson City, TN |
| 29 | Sat Feb 22 | vsWofford | W67-66 | -7½ | 23-6 | .793 | - | | Bon Secours Wellness Arena · Greenville, SC |
| 30 | Wed Feb 26 | atUNC Greensboro | W81-67 | +4½ | 24-6 | .800 | - | | Greensboro Coliseum · Greensboro, NC |
| 31 | Sat Feb 29 | vsThe Citadel | W82-58 | -20½ | 25-6 | .806 | - | | Timmons Arena · Greenville, SC |
| 32 | Sat Mar 7 | vsWofford | L68-77 | -5½ | 25-7 | .781 | - | | Timmons Arena · Greenville, SC |
