| 1 | Tue Nov 5 | vs Old Dominion | W58-53 | 1-0 | 1.000 | - | | McLeod Center · Cedar Falls, IA |
| 2 | Sat Nov 9 | at N Illinois | W64-54 | 2-0 | 1.000 | - | | NIU Convocation Center · Dekalb, IL |
| 3 | Wed Nov 13 | vs Bakersfield | W67-55 | 3-0 | 1.000 | - | | McLeod Center · Cedar Falls, IA |
| 4 | Sat Nov 16 | vs N Colorado | W77-72 (OT) | 4-0 | 1.000 | - | | McLeod Center · Cedar Falls, IA |
| 5 | Tue Nov 19 | vs UT Martin | W87-67 | 5-0 | 1.000 | - | | McLeod Center · Cedar Falls, IA |
| 6 | Wed Nov 20 | vs TBD | W88-66 | 6-0 | 1.000 | - | | McLeod Center · Cedar Falls, IA |
| 7 | Tue Nov 26 | at West Virginia | L55-60 | 6-1 | .857 | - | CBS | WVU Coliseum · Morgantown, WV |
| 8 | Wed Nov 27 | vs South Carolina | W78-72 | 7-1 | .875 | - | CBS | McLeod Center · Cedar Falls, IA |
| 9 | Mon Dec 2 | vsTBD | W110-51 | 8-1 | .889 | - | | McLeod Center · Cedar Falls, IA |
| 10 | Tue Dec 10 | at #24Colorado | W79-76 | 9-1 | .900 | - | PACN | CU Events Center · Boulder, CO |
| 11 | Thu Dec 12 | at Grand Canyon | W82-58 | 10-1 | .909 | - | | GCU Arena · Phoenix, AZ |
| 12 | Sun Dec 22 | vs Marshall | W88-80 | 11-1 | .917 | - | | McLeod Center · Cedar Falls, IA |
| 13 | Tue Dec 31 | at Illinois St | L70-76 | 11-2 | .846 | - | | Redbird Arena · Normal, IL |
| 14 | Sat Jan 4 | vs Bradley | W69-64 | 12-2 | .857 | - | ESPNU | McLeod Center · Cedar Falls, IA |
| 15 | Tue Jan 7 | vs Indiana St | W68-60 | 13-2 | .867 | - | | McLeod Center · Cedar Falls, IA |
| 16 | Sat Jan 11 | at Missouri St | W80-57 | 14-2 | .875 | - | | Great Southern Bank Arena · Springfield, MO |
| 17 | Wed Jan 15 | vs Valparaiso | W88-78 | 15-2 | .882 | - | | McLeod Center · Cedar Falls, IA |
| 18 | Sat Jan 18 | atBradley | W86-71 | 16-2 | .889 | - | ESPN2 | Carver Arena · Peoria, IL |
| 19 | Wed Jan 22 | at S Illinois | L66-68 | 16-3 | .842 | - | | Banterra Center · Carbondale, IL |
| 20 | Sun Jan 26 | vs Loyola Chicago | W67-62 (OT) | 17-3 | .850 | - | ESPNU | McLeod Center · Cedar Falls, IA |
| 21 | Wed Jan 29 | vsMissouri St | W95-66 | 18-3 | .857 | - | | McLeod Center · Cedar Falls, IA |
| 22 | Sat Feb 1 | at Evansville | W80-68 | 19-3 | .864 | - | | Ford Center · Evansville, IN |
| 23 | Wed Feb 5 | atValparaiso | W63-51 | 20-3 | .870 | - | | Athletics-Recreation Center · Valparaiso, IN |
| 24 | Sat Feb 8 | vs Drake | W83-73 | 21-3 | .875 | - | | McLeod Center · Cedar Falls, IA |
| 25 | Wed Feb 12 | vsIllinois St | W71-63 | 22-3 | .880 | - | | McLeod Center · Cedar Falls, IA |
| 26 | Sat Feb 15 | atLoyola Chicago | L73-82 (OT) | 22-4 | .846 | - | ESPN2 | Joseph J. Gentile Arena · Chicago, IL |
| 27 | Thu Feb 20 | atIndiana St | L64-67 | 22-5 | .815 | - | | Hulman Center · Terre Haute, IN |
| 28 | Sun Feb 23 | vsS Illinois | W64-52 | 23-5 | .821 | - | ESPNU | McLeod Center · Cedar Falls, IA |
| 29 | Wed Feb 26 | vsEvansville | W84-64 | 24-5 | .828 | - | | McLeod Center · Cedar Falls, IA |
| 30 | Sat Feb 29 | atDrake | W70-43 | 25-5 | .833 | - | ESPN2 | The Knapp Center · Des Moines, IA |
| 31 | Fri Mar 6 | vsDrake | L56-77 | 25-6 | .806 | - | | McLeod Center · Cedar Falls, IA |
