| 1 | Tue Nov 9 | vs Nicholls | L58-62 | 0-1 | .000 | - | | McLeod Center · Cedar Falls, IA |
| 2 | Thu Nov 11 | vsVermont | L57-71 | 0-2 | .000 | - | | McLeod Center · Cedar Falls, IA |
| 3 | Sun Nov 14 | vsTBD | W95-58 | 1-2 | .333 | - | | McLeod Center · Cedar Falls, IA |
| 4 | Wed Nov 17 | at#16Arkansas | L80-93 | 1-3 | .250 | - | | Bud Walton Arena · Fayetteville, AR |
| 5 | Sat Nov 27 | at#16St Bonaventure | W90-80 | 2-3 | .400 | - | | Reilly Center · Saint Bonaventure, NY |
| 6 | Wed Dec 1 | atBradley | L69-71 | 2-4 | .333 | - | | Carver Arena · Peoria, IL |
| 7 | Sun Dec 5 | vsRichmond | L52-60 | 2-5 | .286 | - | | McLeod Center · Cedar Falls, IA |
| 8 | Tue Dec 14 | vsJackson St | W66-56 | 3-5 | .375 | - | | McLeod Center · Cedar Falls, IA |
| 9 | Sat Dec 18 | atMarshall | W75-60 | 4-5 | .444 | - | | Cam Henderson Center · Huntington, WV |
| 10 | Wed Dec 22 | vsLiberty | L74-76 | 4-6 | .400 | - | ESPNU | Stan Sheriff Center · Honolulu, HI |
| 11 | Thu Dec 23 | atWyoming | L69-71 | 4-7 | .364 | - | ESPNU | Stan Sheriff Center · Honolulu, HI |
| 14 | Sun Jan 2 | vsEvansville | W83-61 | 5-7 | .417 | - | | McLeod Center · Cedar Falls, IA |
| 15 | Wed Jan 5 | vsValparaiso | W92-65 | 6-7 | .462 | - | | McLeod Center · Cedar Falls, IA |
| 16 | Sat Jan 8 | atMissouri St | W85-84 | 7-7 | .500 | - | CBSSN | Great Southern Bank Arena · Springfield, MO |
| 17 | Tue Jan 11 | vsIndiana St | W80-74 (OT) | 8-7 | .533 | - | | McLeod Center · Cedar Falls, IA |
| 18 | Sat Jan 15 | atS Illinois | W69-68 | 9-7 | .563 | - | | Banterra Center · Carbondale, IL |
| 19 | Wed Jan 19 | atValparaiso | L80-83 (OT) | 9-8 | .529 | - | | Athletics-Recreation Center · Valparaiso, IN |
| 20 | Sat Jan 22 | vsDrake | L74-82 (OT) | 9-9 | .500 | - | ESPNU | McLeod Center · Cedar Falls, IA |
| 21 | Wed Jan 26 | atEvansville | W64-59 | 10-9 | .526 | - | | Ford Center · Evansville, IN |
| 22 | Sat Jan 29 | vsIllinois St | W79-64 | 11-9 | .550 | - | | McLeod Center · Cedar Falls, IA |
| 23 | Wed Feb 2 | vsBradley | W78-65 | 12-9 | .571 | - | | McLeod Center · Cedar Falls, IA |
| 24 | Sat Feb 5 | atDrake | W74-69 (OT) | 13-9 | .591 | - | ESPNU | The Knapp Center · Des Moines, IA |
| 25 | Wed Feb 9 | vsS Illinois | W53-44 | 14-9 | .609 | - | | McLeod Center · Cedar Falls, IA |
| 26 | Sun Feb 13 | atLoyola Chicago | L58-85 | 14-10 | .583 | - | ESPN2 | Joseph J. Gentile Arena · Chicago, IL |
| 27 | Tue Feb 15 | atIllinois St | W72-70 | 15-10 | .600 | - | | Redbird Arena · Normal, IL |
| 28 | Sun Feb 20 | vsMissouri St | W95-75 | 16-10 | .615 | - | ESPNU | McLeod Center · Cedar Falls, IA |
| 29 | Wed Feb 23 | atIndiana St | W88-82 | 17-10 | .630 | - | | Hulman Center · Terre Haute, IN |
| 30 | Sat Feb 26 | vsLoyola Chicago | W102-96 (OT) | 18-10 | .643 | - | ESPNU | McLeod Center · Cedar Falls, IA |
| 31 | Fri Mar 4 | vsIllinois St | W78-65 | 19-10 | .655 | - | | McLeod Center · Cedar Falls, IA |
| 32 | Sat Mar 5 | vsLoyola Chicago | L43-66 | 19-11 | .633 | - | CBSSN | McLeod Center · Cedar Falls, IA |
| 33 | Wed Mar 16 | atSaint Louis | W80-68 | 20-11 | .645 | - | | Chaifetz Arena · St. Louis, MO |
| 34 | Sat Mar 19 | atBYU | L71-90 | 20-12 | .625 | - | | Marriott Center · Provo, UT |
