| 1 | Tue Nov 5 | vs UC Davis | W82-48 | 1-0 | 1.000 | - | | Joseph J. Gentile Arena · Chicago, IL |
| 2 | Fri Nov 8 | atFurman | L63-87 | 1-1 | .500 | - | | Timmons Arena · Greenville, SC |
| 3 | Tue Nov 12 | vsCoppin St | L72-76 | 1-2 | .333 | - | | Joseph J. Gentile Arena · Chicago, IL |
| 4 | Sat Nov 16 | vsSaint Joseph's | W85-68 | 2-2 | .500 | - | | Joseph J. Gentile Arena · Chicago, IL |
| 5 | Wed Nov 20 | vsIU Indy | W85-62 | 3-2 | .600 | - | | Joseph J. Gentile Arena · Chicago, IL |
| 6 | Mon Nov 25 | atSouth Florida | L55-66 | 3-3 | .500 | - | | Yuengling Center · Tampa, FL |
| 7 | Tue Nov 26 | vsColorado St | L60-61 | 3-4 | .429 | - | | Joseph J. Gentile Arena · Chicago, IL |
| 8 | Wed Nov 27 | atOld Dominion | W68-61 | 4-4 | .500 | - | | Chartway Arena · Norfolk, VA |
| 9 | Tue Dec 3 | atBall State | W70-58 | 5-4 | .556 | - | | Worthen Arena · Muncie, IN |
| 10 | Sat Dec 7 | vsTBD | W90-59 | 6-4 | .600 | - | | Joseph J. Gentile Arena · Chicago, IL |
| 11 | Sun Dec 15 | vsNorfolk St | W64-45 | 7-4 | .636 | - | | Joseph J. Gentile Arena · Chicago, IL |
| 12 | Wed Dec 18 | atVanderbilt | W78-70 | 8-4 | .667 | - | CBS | Memorial Gymnasium (TN) · Nashville, TN |
| 13 | Sun Dec 22 | vsDavidson | L56-59 | 8-5 | .615 | - | | Joseph J. Gentile Arena · Chicago, IL |
| 14 | Mon Dec 30 | atValparaiso | W66-63 | 9-5 | .643 | - | | Athletics-Recreation Center · Valparaiso, IN |
| 15 | Sat Jan 4 | vsMissouri St | W62-58 | 10-5 | .667 | - | | Joseph J. Gentile Arena · Chicago, IL |
| 16 | Tue Jan 7 | atDrake | L62-65 | 10-6 | .625 | - | CBS | The Knapp Center · Des Moines, IA |
| 17 | Sat Jan 11 | vsEvansville | W78-44 | 11-6 | .647 | - | | Joseph J. Gentile Arena · Chicago, IL |
| 18 | Thu Jan 16 | vsS Illinois | W64-48 | 12-6 | .667 | - | | Joseph J. Gentile Arena · Chicago, IL |
| 19 | Sun Jan 19 | atIllinois St | W62-50 | 13-6 | .684 | - | ESPNU | Redbird Arena · Normal, IL |
| 20 | Wed Jan 22 | vsIndiana St | W75-55 | 14-6 | .700 | - | | Joseph J. Gentile Arena · Chicago, IL |
| 21 | Sun Jan 26 | atNorthern Iowa | L62-67 (OT) | 14-7 | .667 | - | ESPNU | McLeod Center · Cedar Falls, IA |
| 22 | Wed Jan 29 | atS Illinois | L63-68 | 14-8 | .636 | - | | Banterra Center · Carbondale, IL |
| 23 | Sat Feb 1 | vsBradley | W62-51 | 15-8 | .652 | - | ESPN2 | Joseph J. Gentile Arena · Chicago, IL |
| 24 | Wed Feb 5 | atIndiana St | L39-68 | 15-9 | .625 | - | CBS | Hulman Center · Terre Haute, IN |
| 25 | Sun Feb 9 | vsValparaiso | W70-68 | 16-9 | .640 | - | ESPNU | Joseph J. Gentile Arena · Chicago, IL |
| 26 | Wed Feb 12 | atEvansville | W73-66 | 17-9 | .654 | - | | Ford Center · Evansville, IN |
| 27 | Sat Feb 15 | vsNorthern Iowa | W82-73 (OT) | 18-9 | .667 | - | ESPN2 | Joseph J. Gentile Arena · Chicago, IL |
| 28 | Wed Feb 19 | vsIllinois St | W84-69 | 19-9 | .679 | - | | Joseph J. Gentile Arena · Chicago, IL |
| 29 | Sat Feb 22 | atMissouri St | L62-74 | 19-10 | .655 | - | CBS | Great Southern Bank Arena · Springfield, MO |
| 30 | Tue Feb 25 | vsDrake | W64-60 | 20-10 | .667 | - | | Joseph J. Gentile Arena · Chicago, IL |
| 31 | Sat Feb 29 | atBradley | W67-66 | 21-10 | .677 | - | | Carver Arena · Peoria, IL |
| 32 | Fri Mar 6 | vsValparaiso | L73-74 (OT) | 21-11 | .656 | - | | Joseph J. Gentile Arena · Chicago, IL |
