| 1 | Wed Nov 8 | vs #10FAU | L62-75 | 0-1 | .000 | - | | Joseph J. Gentile Arena · Chicago, IL |
| 2 | Sat Nov 11 | vs E Illinois | W89-65 | 1-1 | .500 | - | | Joseph J. Gentile Arena · Chicago, IL |
| 3 | Tue Nov 14 | vs UIC | L67-72 | 1-2 | .333 | - | | Joseph J. Gentile Arena · Chicago, IL |
| 4 | Sat Nov 18 | vs New Orleans | W73-70 | 2-2 | .500 | - | | Joseph J. Gentile Arena · Chicago, IL |
| 5 | Wed Nov 22 | at #8Creighton | L65-88 | 2-3 | .400 | - | CBS | CHI Health Center Omaha · Omaha, NE |
| 6 | Thu Nov 23 | vs Boston College | W71-68 | 3-3 | .500 | - | | Joseph J. Gentile Arena · Chicago, IL |
| 7 | Tue Nov 28 | vs Chicago St | W62-53 | 4-3 | .571 | - | | Joseph J. Gentile Arena · Chicago, IL |
| 8 | Sat Dec 2 | vs Harvard | W75-53 | 5-3 | .625 | - | | Joseph J. Gentile Arena · Chicago, IL |
| 9 | Tue Dec 5 | at Tulsa | L77-88 | 5-4 | .556 | - | | Donald W. Reynolds Center · Tulsa, OK |
| 10 | Sat Dec 9 | vs TBD | W115-64 | 6-4 | .600 | - | | Joseph J. Gentile Arena · Chicago, IL |
| 11 | Sat Dec 16 | at South Florida | L64-77 | 6-5 | .545 | - | | Yuengling Center · Tampa, FL |
| 12 | Tue Dec 19 | vs Charleston So | W72-59 | 7-5 | .583 | - | | Joseph J. Gentile Arena · Chicago, IL |
| 13 | Sat Dec 30 | vs C Michigan | W73-35 | 8-5 | .615 | - | | Joseph J. Gentile Arena · Chicago, IL |
| 14 | Wed Jan 3 | at Saint Louis | W80-73 | 9-5 | .643 | - | | Chaifetz Arena · St. Louis, MO |
| 15 | Sat Jan 6 | vs Duquesne | W72-67 | 10-5 | .667 | - | CBS | Joseph J. Gentile Arena · Chicago, IL |
| 16 | Tue Jan 9 | vs Richmond | L56-58 | 10-6 | .625 | - | | Joseph J. Gentile Arena · Chicago, IL |
| 17 | Sat Jan 13 | at Saint Joseph's | W78-75 | 11-6 | .647 | - | ESPNU | Michael J. Hagan '85 Arena · Philadelphia, PA |
| 18 | Wed Jan 17 | vs UMass | W79-78 | 12-6 | .667 | - | CBS | Joseph J. Gentile Arena · Chicago, IL |
| 19 | Sat Jan 20 | at Fordham | W65-61 | 13-6 | .684 | - | | Rose Hill Gymnasium · Bronx, NY |
| 20 | Tue Jan 23 | at VCU | L67-74 | 13-7 | .650 | - | CBS | Stuart C. Siegel Center · Richmond, VA |
| 21 | Tue Jan 30 | vsSaint Louis | W77-62 | 14-7 | .667 | - | | Joseph J. Gentile Arena · Chicago, IL |
| 22 | Sun Feb 4 | vs Davidson | W76-63 | 15-7 | .682 | - | CBS | Joseph J. Gentile Arena · Chicago, IL |
| 23 | Wed Feb 7 | at George Mason | W85-79 | 16-7 | .696 | - | | EagleBank Arena · Fairfax, VA |
| 24 | Sat Feb 10 | at G Washington | W81-73 | 17-7 | .708 | - | | Charles E. Smith Center · Washington, D.C. |
| 25 | Wed Feb 14 | vsSaint Joseph's | W64-59 | 18-7 | .720 | - | | Joseph J. Gentile Arena · Chicago, IL |
| 26 | Sun Feb 18 | at Rhode Island | W77-67 | 19-7 | .731 | - | CBS | Ryan Center · Kingston, RI |
| 27 | Sat Feb 24 | vsGeorge Mason | W80-59 | 20-7 | .741 | - | USA Net | Joseph J. Gentile Arena · Chicago, IL |
| 28 | Tue Feb 27 | at St Bonaventure | L64-79 | 20-8 | .714 | - | | Reilly Center · Saint Bonaventure, NY |
| 29 | Fri Mar 1 | vs #21Dayton | W77-72 | 21-8 | .724 | - | ESPN2 | Joseph J. Gentile Arena · Chicago, IL |
| 30 | Wed Mar 6 | atDavidson | W69-59 | 22-8 | .733 | - | | John M. Belk Arena · Davidson, NC |
| 31 | Sat Mar 9 | vs La Salle | W64-54 | 23-8 | .742 | - | | Joseph J. Gentile Arena · Chicago, IL |
| 32 | Thu Mar 14 | vsSt Bonaventure | L74-75 (2OT) | 23-9 | .719 | - | USA Net | Joseph J. Gentile Arena · Chicago, IL |
| 33 | Wed Mar 20 | at Bradley | L62-74 | 23-10 | .697 | - | | Carver Arena · Peoria, IL |
