| 1 | Sat Dec 5 | vs TBD | W76-48 | 1-0 | 1.000 | - | | Joseph J. Gentile Arena · Chicago, IL |
| 2 | Wed Dec 9 | vsChicago St | W88-51 | 2-0 | 1.000 | - | | Joseph J. Gentile Arena · Chicago, IL |
| 3 | Sun Dec 13 | atUIC | W77-66 | 3-0 | 1.000 | - | | Credit Union 1 Arena · Chicago, IL |
| 4 | Tue Dec 15 | at12Wisconsin | L63-77 | 3-1 | .750 | - | BTN | Kohl Center · Madison, WI |
| 5 | Fri Dec 18 | vsRichmond | L73-75 | 3-2 | .600 | - | | Joseph J. Gentile Arena · Chicago, IL |
| 6 | Tue Dec 22 | vsTBD | W92-55 | 4-2 | .667 | - | | Joseph J. Gentile Arena · Chicago, IL |
| 7 | Sun Dec 27 | vsIllinois St | W90-60 | 5-2 | .714 | - | | Joseph J. Gentile Arena · Chicago, IL |
| 8 | Mon Dec 28 | vsIllinois St | W86-55 | 6-2 | .750 | - | CBSSN | Joseph J. Gentile Arena · Chicago, IL |
| 9 | Sat Jan 2 | vsNorth Texas | W57-49 | 7-2 | .778 | - | | Joseph J. Gentile Arena · Chicago, IL |
| 10 | Sun Jan 3 | atBradley | PPD | 26-5 | .839 | - | ESPNU | Carver Arena · Peoria, IL |
| 11 | Mon Jan 4 | atBradley | PPD | 26-5 | .839 | - | CBSSN | Carver Arena · Peoria, IL |
| 12 | Sun Jan 10 | atIndiana St | L71-76 | 7-3 | .700 | - | ESPN2 | Hulman Center · Terre Haute, IN |
| 13 | Mon Jan 11 | atIndiana St | W58-48 | 8-3 | .727 | - | | Hulman Center · Terre Haute, IN |
| 14 | Sat Jan 16 | vsNorthern Iowa | W72-57 | 9-3 | .750 | - | ESPN2 | Joseph J. Gentile Arena · Chicago, IL |
| 15 | Sun Jan 17 | vsNorthern Iowa | W88-46 | 10-3 | .769 | - | ESPN | Joseph J. Gentile Arena · Chicago, IL |
| 16 | Wed Jan 20 | atValparaiso | W75-39 | 11-3 | .786 | - | | Athletics-Recreation Center · Valparaiso, IN |
| 17 | Sun Jan 24 | atBradley | W69-56 | 12-3 | .800 | - | | Carver Arena · Peoria, IL |
| 18 | Mon Jan 25 | atBradley | W65-58 | 13-3 | .813 | - | CBSSN | Carver Arena · Peoria, IL |
| 19 | Sun Jan 31 | atMissouri St | W72-46 | 14-3 | .824 | - | CBSSN | Great Southern Bank Arena · Springfield, MO |
| 20 | Mon Feb 1 | atMissouri St | W70-50 | 15-3 | .833 | - | | Great Southern Bank Arena · Springfield, MO |
| 21 | Sat Feb 6 | vsEvansville | W68-55 | 16-3 | .842 | - | | Joseph J. Gentile Arena · Chicago, IL |
| 22 | Sun Feb 7 | vsEvansville | W69-58 | 17-3 | .850 | - | | Joseph J. Gentile Arena · Chicago, IL |
| 23 | Sat Feb 13 | atDrake | W81-54 | 18-3 | .857 | #22 | ESPN2 | The Knapp Center · Des Moines, IA |
| 24 | Sun Feb 14 | atDrake | L50-51 (OT) | 18-4 | .818 | #22 | ESPN2 | The Knapp Center · Des Moines, IA |
| 25 | Wed Feb 17 | vsValparaiso | W54-52 | 19-4 | .826 | #22 | | Joseph J. Gentile Arena · Chicago, IL |
| 26 | Fri Feb 26 | vsS Illinois | W60-52 | 20-4 | .833 | #21 | CBSSN | Joseph J. Gentile Arena · Chicago, IL |
| 27 | Sat Feb 27 | vsS Illinois | W65-58 (OT) | 21-4 | .840 | #21 | ESPN2 | Joseph J. Gentile Arena · Chicago, IL |
| 28 | Fri Mar 5 | vsS Illinois | W73-49 | 22-4 | .846 | - | | Enterprise Center · St. Louis, MO |
| 29 | Sat Mar 6 | vsIndiana St | W65-49 | 23-4 | .852 | - | CBSSN | Enterprise Center · St. Louis, MO |
| 30 | Sun Mar 7 | vsDrake | W75-65 | 24-4 | .857 | - | CBS | Enterprise Center · St. Louis, MO |
| 31 | Fri Mar 19 | vs9Georgia Tech | W71-60 | 25-4 | .862 | #8 | TBS | Hinkle Fieldhouse · Indianapolis, IN |
| 32 | Sun Mar 21 | at1Illinois | W71-58 | 26-4 | .867 | #8 | CBS | State Farm Center · Champaign, IL |
| 33 | Sat Mar 27 | vs12Oregon St | L58-65 | 26-5 | .839 | #8 | CBS | Joseph J. Gentile Arena · Chicago, IL |
