| 1 | Mon Nov 3 | vs Montana St | 9:00 PM | 15-18 | .455 | - | ESPN+ | CU Events Center · Boulder, CO |
| 2 | Sat Nov 8 | vsE Washington | TBD | 10-22 | .313 | - | ESPN+ | CU Events Center · Boulder, CO |
| 3 | Fri Nov 14 | vsProvidence | 9:00 PM | 12-20 | .375 | - | ESPN+ | CU Events Center · Boulder, CO |
| 4 | Mon Nov 17 | vsAlabama St | 9:00 PM | 20-16 | .556 | - | ESPN+ | CU Events Center · Boulder, CO |
| 5 | Fri Nov 21 | vsUC Davis | 9:00 PM | 15-17 | .469 | - | ESPN+ | CU Events Center · Boulder, CO |
| 6 | Thu Nov 27 | vsSan Francisco | 2:00 PM | 25-10 | .714 | - | CBS | CU Events Center · Boulder, CO |
| 7 | Mon Dec 1 | vsCA Baptist | 9:00 PM | 17-15 | .531 | - | ESPN+ | CU Events Center · Boulder, CO |
| 8 | Sat Dec 6 | atColorado St | TBD | 26-10 | .722 | - | CBS | Moby Arena · Fort Collins, CO |
| 9 | Sat Dec 13 | vsUTSA | 4:00 PM | 12-19 | .387 | - | ESPN+ | CU Events Center · Boulder, CO |
| 10 | Wed Dec 17 | vsPortland St | 9:00 PM | 19-13 | .594 | - | ESPN+ | CU Events Center · Boulder, CO |
| 11 | Sat Dec 20 | vsStanford | 8:00 PM | 21-14 | .600 | - | ESPNU | CU Events Center · Boulder, CO |
| 12 | Sun Dec 28 | vsN Colorado | 3:00 PM | 25-10 | .714 | - | ESPN+ | CU Events Center · Boulder, CO |
| 13 | Sat Jan 3 | atArizona St | 5:00 PM | 13-20 | .394 | - | TNT | Desert Financial Arena · Tempe, AZ |
| 14 | Wed Jan 7 | vsUtah | 9:00 PM | 16-17 | .485 | - | ESPN+ | CU Events Center · Boulder, CO |
| 15 | Sat Jan 10 | vs#10Texas Tech | 7:00 PM | 28-9 | .757 | - | CBS | CU Events Center · Boulder, CO |
| 16 | Wed Jan 14 | atCincinnati | 7:00 PM | 19-16 | .543 | - | Peacock | Fifth Third Arena · Cincinnati, OH |
| 17 | Sat Jan 17 | atWest Virginia | 6:00 PM | 19-13 | .594 | - | CBS | WVU Coliseum · Morgantown, WV |
| 18 | Sun Jan 18 | vs#19Kansas | 11:00 PM | 21-13 | .618 | - | ESPN | CU Events Center · Boulder, CO |
| 19 | Sat Jan 24 | vsUCF | 3:00 PM | 20-17 | .541 | - | ESPN+ | CU Events Center · Boulder, CO |
| 20 | Thu Jan 29 | at#16Iowa State | 7:00 PM | 25-10 | .714 | - | FS1 | James H. Hilton Coliseum · Ames, IA |
| 21 | Sun Feb 1 | vsTCU | 2:00 PM | 16-16 | .500 | - | TNT | CU Events Center · Boulder, CO |
| 22 | Wed Feb 4 | atBaylor | 8:00 PM | 20-15 | .571 | - | Peacock | Ferrell Center · Waco, TX |
| 23 | Sat Feb 7 | vsArizona St | 2:00 PM | 13-20 | .394 | - | TNT | CU Events Center · Boulder, CO |
| 24 | Wed Feb 11 | at#10Texas Tech | 8:00 PM | 28-9 | .757 | - | ESPN+ | United Supermarkets Arena · Lubbock, TX |
| 25 | Sat Feb 14 | at#8BYU | 4:00 PM | 26-10 | .722 | - | FS1 | Marriott Center · Provo, UT |
| 26 | Sat Feb 21 | vsOklahoma St | 3:30 PM | 17-18 | .486 | - | TNT | CU Events Center · Boulder, CO |
| 27 | Wed Feb 25 | vsKansas St | 9:00 PM | 16-17 | .485 | - | FS1 | CU Events Center · Boulder, CO |
| 28 | Sat Feb 28 | at#2Houston | 12:00 PM | 35-5 | .875 | - | | Fertitta Center · Houston, TX |
| 29 | Tue Mar 3 | atUtah | 9:00 PM | 16-17 | .485 | - | ESPN+ | Jon M. Huntsman Center · Salt Lake City, UT |
| 30 | Sat Mar 7 | vs#13Arizona | 11:00 PM | 24-13 | .649 | - | ESPN2 | CU Events Center · Boulder, CO |
