| 1 | Tue Nov 9 | vs Montana St | W94-90 (OT) | 1-0 | 1.000 | - | | CU Events Center · Boulder, CO |
| 2 | Sat Nov 13 | vsNew Mexico | W87-76 | 2-0 | 1.000 | - | | CU Events Center · Boulder, CO |
| 3 | Mon Nov 15 | vsMaine | W90-46 | 3-0 | 1.000 | - | PACN | CU Events Center · Boulder, CO |
| 4 | Fri Nov 19 | vsS Illinois | L63-67 | 3-1 | .750 | - | | CU Events Center · Boulder, CO |
| 5 | Sat Nov 20 | vsDuquesne | W84-76 (OT) | 4-1 | .800 | - | | CU Events Center · Boulder, CO |
| 6 | Mon Nov 22 | vsBrown | W54-52 | 5-1 | .833 | - | | CU Events Center · Boulder, CO |
| 7 | Sun Nov 28 | vsStanford | W80-76 | 6-1 | .857 | - | PACN | CU Events Center · Boulder, CO |
| 8 | Wed Dec 1 | at#5UCLA | L61-73 | 6-2 | .750 | - | PACN | Pauley Pavilion · Los Angeles, CA |
| 9 | Sat Dec 4 | vs#13Tennessee | L54-69 | 6-3 | .667 | - | FS1 | CU Events Center · Boulder, CO |
| 10 | Wed Dec 8 | vsE Washington | W60-57 | 7-3 | .700 | - | | CU Events Center · Boulder, CO |
| 11 | Fri Dec 10 | vsMilwaukee | W65-54 | 8-3 | .727 | - | | CU Events Center · Boulder, CO |
| 12 | Sat Dec 18 | vsBakersfield | W60-46 | 9-3 | .750 | - | | CU Events Center · Boulder, CO |
| 14 | Thu Dec 30 | atOregon | PPD | 21-12 | .636 | - | PACN | Matthew Knight Arena · Eugene, OR |
| 15 | Sat Jan 1 | atOregon St | PPD | 21-12 | .636 | - | PACN | Gill Coliseum · Corvallis, OR |
| 16 | Mon Jan 3 | atOregon | PPD | 21-12 | .636 | - | | Matthew Knight Arena · Eugene, OR |
| 17 | Thu Jan 6 | vsWashington St | W83-78 | 10-3 | .769 | - | ESPN2 | CU Events Center · Boulder, CO |
| 18 | Sun Jan 9 | vsWashington | W78-64 | 11-3 | .786 | - | ESPN2 | CU Events Center · Boulder, CO |
| 19 | Thu Jan 13 | at#6Arizona | L55-76 | 11-4 | .733 | - | FS1 | McKale Center · Tucson, AZ |
| 20 | Sat Jan 15 | atArizona St | W75-57 | 12-4 | .750 | - | ESPN2 | Desert Financial Arena · Tempe, AZ |
| 21 | Thu Jan 20 | vs#16USC | L58-61 | 12-5 | .706 | - | PACN | CU Events Center · Boulder, CO |
| 22 | Sat Jan 22 | vs#9UCLA | L65-71 | 12-6 | .667 | - | | CU Events Center · Boulder, CO |
| 23 | Tue Jan 25 | atOregon | W82-78 | 13-6 | .684 | - | PACN | Matthew Knight Arena · Eugene, OR |
| 24 | Thu Jan 27 | atWashington | L58-60 | 13-7 | .650 | - | PACN | Alaska Airlines Arena · Seattle, WA |
| 25 | Sun Jan 30 | atWashington St | L43-70 | 13-8 | .619 | - | FS1 | Friel Court at Beasley Coliseum · Pullman, WA |
| 26 | Thu Feb 3 | vsOregon | L51-66 | 13-9 | .591 | - | FS1 | CU Events Center · Boulder, CO |
| 27 | Sat Feb 5 | vsOregon St | W86-63 | 14-9 | .609 | - | FS1 | CU Events Center · Boulder, CO |
| 28 | Sat Feb 12 | vsUtah | W81-76 | 15-9 | .625 | - | PACN | CU Events Center · Boulder, CO |
| 29 | Tue Feb 15 | atOregon St | W90-64 | 16-9 | .640 | - | PACN | Gill Coliseum · Corvallis, OR |
| 30 | Thu Feb 17 | atCalifornia | W70-62 | 17-9 | .654 | - | PACN | Haas Pavilion · Berkeley, CA |
| 31 | Sat Feb 19 | atStanford | W70-53 | 18-9 | .667 | - | ESPNU | Maples Pavilion · Stanford, CA |
| 32 | Thu Feb 24 | vsArizona St | L65-82 | 18-10 | .643 | - | PACN | CU Events Center · Boulder, CO |
| 33 | Sat Feb 26 | vs#2Arizona | W79-63 | 19-10 | .655 | - | ESPN2 | CU Events Center · Boulder, CO |
| 34 | Sat Mar 5 | atUtah | W84-71 | 20-10 | .667 | - | ESPNU | Jon M. Huntsman Center · Salt Lake City, UT |
| 35 | Thu Mar 10 | vsOregon | W80-69 | 21-10 | .677 | - | PACN | CU Events Center · Boulder, CO |
| 36 | Fri Mar 11 | atArizona | L72-82 | 21-11 | .656 | - | PACN | McKale Center · Tucson, AZ |
| 37 | Tue Mar 15 | vsSt Bonaventure | L68-76 | 21-12 | .636 | - | ESPN2 | CU Events Center · Boulder, CO |
