| 1 | Mon Nov 7 | vs UC Riverside | W82-66 | 1-0 | 1.000 | - | | CU Events Center · Boulder, CO |
| 2 | Fri Nov 11 | at Grambling | L74-83 | 1-1 | .500 | - | | Fredrick C. Hobdy Assembly Center · Grambling, LA |
| 3 | Sun Nov 13 | at #11Tennessee | W78-66 | 2-1 | .667 | - | ESPN | Thompson-Boling Arena · Knoxville, TN |
| 4 | Thu Nov 17 | at UMass | L63-66 | 2-2 | .500 | - | ESPNU | William D. Mullins Memorial Center · Amherst, MA |
| 5 | Fri Nov 18 | at Texas A&M | W103-75 | 3-2 | .600 | - | ESPNU | Reed Arena · College Station, TX |
| 6 | Sun Nov 20 | at Boise St | L55-68 | 3-3 | .500 | - | ESPNEWS | ExtraMile Arena · Boise, ID |
| 7 | Sun Nov 27 | vs Yale | W65-62 | 4-3 | .571 | - | PACN | CU Events Center · Boulder, CO |
| 8 | Thu Dec 1 | vs Arizona St | L59-60 | 4-4 | .500 | - | FS1 | CU Events Center · Boulder, CO |
| 9 | Sun Dec 4 | at Washington | L63-73 | 4-5 | .444 | - | PACN | Alaska Airlines Arena · Seattle, WA |
| 10 | Thu Dec 8 | vs Colorado St | W93-65 | 5-5 | .500 | - | ESPN2 | CU Events Center · Boulder, CO |
| 11 | Thu Dec 15 | vs North Alabama | W84-60 | 6-5 | .545 | - | PACN | CU Events Center · Boulder, CO |
| 12 | Sun Dec 18 | vs N Colorado | W88-77 | 7-5 | .583 | - | PACN | CU Events Center · Boulder, CO |
| 13 | Wed Dec 21 | vs Southern Utah | W86-78 | 8-5 | .615 | - | PACN | CU Events Center · Boulder, CO |
| 14 | Thu Dec 29 | at Stanford | W73-70 | 9-5 | .643 | - | ESPNU | Maples Pavilion · Stanford, CA |
| 15 | Sat Dec 31 | at California | L76-80 | 9-6 | .600 | - | PACN | Haas Pavilion · Berkeley, CA |
| 16 | Thu Jan 5 | vs Oregon | W68-41 | 10-6 | .625 | - | ESPN2 | CU Events Center · Boulder, CO |
| 17 | Sat Jan 7 | vs Oregon St | W62-42 | 11-6 | .647 | - | PACN | CU Events Center · Boulder, CO |
| 18 | Thu Jan 12 | at USC | L61-68 | 11-7 | .611 | - | PACN | Galen Center · Los Angeles, CA |
| 19 | Sat Jan 14 | at #7UCLA | L54-68 | 11-8 | .579 | - | FOX | Pauley Pavilion · Los Angeles, CA |
| 20 | Thu Jan 19 | vsWashington | L72-75 | 11-9 | .550 | - | ESPNU | CU Events Center · Boulder, CO |
| 21 | Sun Jan 22 | vs Washington St | W58-55 | 12-9 | .571 | - | ESPNU | CU Events Center · Boulder, CO |
| 22 | Thu Jan 26 | atOregon | L69-75 | 12-10 | .545 | - | PACN | Matthew Knight Arena · Eugene, OR |
| 23 | Sat Jan 28 | atOregon St | L52-60 | 12-11 | .522 | - | | Gill Coliseum · Corvallis, OR |
| 24 | Thu Feb 2 | vsCalifornia | W59-46 | 13-11 | .542 | - | PACN | CU Events Center · Boulder, CO |
| 25 | Sun Feb 5 | vsStanford | W84-62 | 14-11 | .560 | - | FS1 | CU Events Center · Boulder, CO |
| 26 | Sat Feb 11 | at Utah | L62-73 | 14-12 | .538 | - | FS1 | Jon M. Huntsman Center · Salt Lake City, UT |
| 27 | Thu Feb 16 | atArizona St | W67-59 | 15-12 | .556 | - | PACN | Desert Financial Arena · Tempe, AZ |
| 28 | Sat Feb 18 | at #8Arizona | L68-78 | 15-13 | .536 | - | ESPN2 | McKale Center · Tucson, AZ |
| 29 | Thu Feb 23 | vsUSC | L65-84 | 15-14 | .517 | - | ESPN2 | CU Events Center · Boulder, CO |
| 30 | Sun Feb 26 | vs#4UCLA | L56-60 | 15-15 | .500 | - | CBS | CU Events Center · Boulder, CO |
| 31 | Sat Mar 4 | vsUtah | W69-60 | 16-15 | .516 | - | PACN | CU Events Center · Boulder, CO |
| 32 | Wed Mar 8 | atWashington | W74-68 | 17-15 | .531 | - | PACN | Alaska Airlines Arena · Seattle, WA |
| 33 | Thu Mar 9 | atUCLA | L69-80 | 17-16 | .515 | - | PACN | Pauley Pavilion · Los Angeles, CA |
| 34 | Tue Mar 14 | vs Seton Hall | W65-64 | 18-16 | .529 | - | ESPN2 | CU Events Center · Boulder, CO |
| 35 | Sun Mar 19 | vs Utah Valley | L69-81 | 18-17 | .514 | - | ESPNU | CU Events Center · Boulder, CO |
