| 1 | Mon Nov 4 | vs E Washington | W76-56 | 1-0 | 1.000 | - | ESPN+ | CU Events Center · Boulder, CO |
| 2 | Fri Nov 8 | vsN Colorado | W90-88 (2OT) | 2-0 | 1.000 | - | ESPN+ | CU Events Center · Boulder, CO |
| 3 | Wed Nov 13 | vsFullerton | W83-53 | 3-0 | 1.000 | - | ESPN+ | CU Events Center · Boulder, CO |
| 4 | Sun Nov 17 | vsHarvard | W88-66 | 4-0 | 1.000 | - | ESPN+ | CU Events Center · Boulder, CO |
| 5 | Mon Nov 25 | atMichigan St | L56-72 | 4-1 | .800 | - | ESPN2 | Breslin Center · East Lansing, MI |
| 6 | Tue Nov 26 | vs#2UConn | W73-72 | 5-1 | .833 | - | ESPN2 | CU Events Center · Boulder, CO |
| 7 | Wed Nov 27 | at#5Iowa State | L71-99 | 5-2 | .714 | - | ESPN2 | James H. Hilton Coliseum · Ames, IA |
| 8 | Mon Dec 2 | vsPacific | W75-66 | 6-2 | .750 | - | ESPN+ | CU Events Center · Boulder, CO |
| 9 | Sat Dec 7 | vsColorado St | W72-55 | 7-2 | .778 | - | ESPN+ | CU Events Center · Boulder, CO |
| 10 | Fri Dec 13 | vsS Dakota St | W81-70 | 8-2 | .800 | - | ESPN+ | CU Events Center · Boulder, CO |
| 11 | Sat Dec 21 | vsBellarmine | W79-55 | 9-2 | .818 | - | ESPN+ | CU Events Center · Boulder, CO |
| 12 | Mon Dec 30 | vs#3Iowa State | L69-79 | 9-3 | .750 | - | CBS | CU Events Center · Boulder, CO |
| 13 | Sat Jan 4 | atArizona St | L61-81 | 9-4 | .692 | - | ESPN+ | Desert Financial Arena · Tempe, AZ |
| 14 | Wed Jan 8 | atUCF | L74-75 | 9-5 | .643 | - | ESPN+ | Addition Financial Arena · Orlando, FL |
| 15 | Sun Jan 12 | vs#21West Virginia | L70-78 | 9-6 | .600 | - | ESPN+ | CU Events Center · Boulder, CO |
| 16 | Wed Jan 15 | vsCincinnati | L62-68 | 9-7 | .563 | - | ESPN+ | CU Events Center · Boulder, CO |
| 17 | Sat Jan 18 | atOklahoma St | L73-83 | 9-8 | .529 | - | ESPN+ | Gallagher-Iba Arena · Stillwater, OK |
| 18 | Tue Jan 21 | vsBYU | L67-83 | 9-9 | .500 | - | ESPNU | CU Events Center · Boulder, CO |
| 19 | Sat Jan 25 | atArizona | L63-78 | 9-10 | .474 | - | ESPN+ | McKale Center · Tucson, AZ |
| 20 | Tue Jan 28 | vsArizona St | L68-70 | 9-11 | .450 | - | ESPN+ | CU Events Center · Boulder, CO |
| 21 | Sun Feb 2 | atTCU | L57-68 | 9-12 | .429 | - | ESPN+ | Ed and Rae Schollmaier Arena · Fort Worth, TX |
| 22 | Wed Feb 5 | atUtah | L59-72 | 9-13 | .409 | - | ESPN+ | Jon M. Huntsman Center · Salt Lake City, UT |
| 23 | Sat Feb 8 | vs#5Houston | L59-69 | 9-14 | .391 | - | ESPN+ | CU Events Center · Boulder, CO |
| 24 | Tue Feb 11 | at#17Kansas | L59-71 | 9-15 | .375 | - | ESPN2 | Allen Fieldhouse · Lawrence, KS |
| 25 | Sat Feb 15 | vsUCF | W76-63 | 10-15 | .400 | - | ESPN+ | CU Events Center · Boulder, CO |
| 26 | Tue Feb 18 | at#8Iowa State | L65-79 | 10-16 | .385 | - | ESPN+ | James H. Hilton Coliseum · Ames, IA |
| 27 | Sat Feb 22 | vsBaylor | W76-74 | 11-16 | .407 | - | ESPN+ | CU Events Center · Boulder, CO |
| 28 | Mon Feb 24 | vsKansas | L64-71 | 11-17 | .393 | - | ESPN | CU Events Center · Boulder, CO |
| 29 | Sun Mar 2 | atKansas St | L56-65 | 11-18 | .379 | - | ESPN+ | Bramlage Coliseum · Manhattan, KS |
| 30 | Wed Mar 5 | at#9Texas Tech | L75-91 | 11-19 | .367 | - | ESPN+ | United Supermarkets Arena · Lubbock, TX |
| 31 | Sat Mar 8 | vsTCU | W76-56 | 12-19 | .387 | - | ESPN+ | CU Events Center · Boulder, CO |
| 32 | Tue Mar 11 | atTCU | W69-67 | 13-19 | .406 | - | ESPN+ | Ed and Rae Schollmaier Arena · Fort Worth, TX |
| 33 | Wed Mar 12 | atWest Virginia | W67-60 | 14-19 | .424 | - | ESPN+ | WVU Coliseum · Morgantown, WV |
| 34 | Thu Mar 13 | at#2Houston | L68-77 | 14-20 | .412 | - | ESPN2 | Fertitta Center · Houston, TX |
| 35 | Tue Apr 1 | vsVillanova | L64-85 | 14-21 | .400 | - | FS1 | CU Events Center · Boulder, CO |
