| 1 | Tue Nov 5 | vs UC Davis | W79-73 | 1-0 | 1.000 | - | BTN | Alaska Airlines Arena · Seattle, WA |
| 2 | Sat Nov 9 | atNevada | L53-63 | 1-1 | .500 | - | | Barclays Center · Brooklyn, NY |
| 3 | Wed Nov 13 | vsTBD | W77-62 | 2-1 | .667 | - | | Alaska Airlines Arena · Seattle, WA |
| 4 | Sun Nov 17 | vsUMass Lowell | W74-69 | 3-1 | .750 | - | B1G+ | Alaska Airlines Arena · Seattle, WA |
| 5 | Fri Nov 22 | vsAlcorn St | W77-60 | 4-1 | .800 | - | B1G+ | Alaska Airlines Arena · Seattle, WA |
| 6 | Thu Nov 28 | atColorado St | W73-67 | 5-1 | .833 | - | truTV | Moby Arena · Fort Collins, CO |
| 7 | Fri Nov 29 | vsSanta Clara | W76-69 | 6-1 | .857 | - | | Alaska Airlines Arena · Seattle, WA |
| 8 | Tue Dec 3 | atUCLA | L58-69 | 6-2 | .750 | - | FS1 | Pauley Pavilion · Los Angeles, CA |
| 9 | Sat Dec 7 | vsUSC | L61-85 | 6-3 | .667 | - | BTN | Alaska Airlines Arena · Seattle, WA |
| 10 | Tue Dec 10 | vsE Washington | W87-69 | 7-3 | .700 | - | BTN | Alaska Airlines Arena · Seattle, WA |
| 11 | Wed Dec 18 | vsWashington St | W89-73 | 8-3 | .727 | - | FS1 | Alaska Airlines Arena · Seattle, WA |
| 12 | Mon Dec 23 | vsSeattle U | L70-79 | 8-4 | .667 | - | BTN | Alaska Airlines Arena · Seattle, WA |
| 13 | Sun Dec 29 | vsNJIT | W90-53 | 9-4 | .692 | - | Peacock | Alaska Airlines Arena · Seattle, WA |
| 14 | Thu Jan 2 | vsMaryland | W75-69 | 10-4 | .714 | - | BTN | Alaska Airlines Arena · Seattle, WA |
| 15 | Sun Jan 5 | vs22Illinois | L77-81 | 10-5 | .667 | - | BTN | Alaska Airlines Arena · Seattle, WA |
| 16 | Thu Jan 9 | at16Michigan St | L54-88 | 10-6 | .625 | - | BTN | Breslin Center · East Lansing, MI |
| 17 | Sun Jan 12 | at24Michigan | L75-91 | 10-7 | .588 | - | BTN | Crisler Center · Ann Arbor, MI |
| 18 | Wed Jan 15 | vs17Purdue | L58-69 | 10-8 | .556 | - | BTN | Alaska Airlines Arena · Seattle, WA |
| 19 | Tue Jan 21 | at15Oregon | L71-82 | 10-9 | .526 | - | BTN | Matthew Knight Arena · Eugene, OR |
| 20 | Fri Jan 24 | vsUCLA | L60-65 | 10-10 | .500 | - | FS1 | Alaska Airlines Arena · Seattle, WA |
| 21 | Sat Feb 1 | atMinnesota | W71-68 | 11-10 | .524 | - | BTN | Williams Arena · Minneapolis, MN |
| 22 | Wed Feb 5 | vsNebraska | L72-86 | 11-11 | .500 | - | BTN | Alaska Airlines Arena · Seattle, WA |
| 23 | Sat Feb 8 | vsNorthwestern | W76-71 | 12-11 | .522 | - | BTN | Alaska Airlines Arena · Seattle, WA |
| 24 | Wed Feb 12 | atOhio State | L69-93 | 12-12 | .500 | - | BTN | Value City Arena · Columbus, OH |
| 25 | Sat Feb 15 | atPenn State | W75-73 | 13-12 | .520 | - | BTN | Bryce Jordan Center · University Park, PA |
| 26 | Wed Feb 19 | vsRutgers | L85-89 (OT) | 13-13 | .500 | - | BTN | Alaska Airlines Arena · Seattle, WA |
| 27 | Sat Feb 22 | atIowa | L79-85 | 13-14 | .481 | - | FS1 | Carver-Hawkeye Arena · Iowa City, IA |
| 28 | Tue Feb 25 | at11Wisconsin | L62-88 | 13-15 | .464 | - | Peacock | Kohl Center · Madison, WI |
| 29 | Sat Mar 1 | vsIndiana | L62-78 | 13-16 | .448 | - | Peacock | Alaska Airlines Arena · Seattle, WA |
| 30 | Wed Mar 5 | atUSC | L61-92 | 13-17 | .433 | - | BTN | Galen Center · Los Angeles, CA |
| 31 | Sun Mar 9 | vsOregon | L73-80 (OT) | 13-18 | .419 | - | BTN | Alaska Airlines Arena · Seattle, WA |
