| 1 | Tue Nov 9 | vs Niagara | W63-60 | 1-0 | 1.000 | - | | Cintas Center · Cincinnati, OH |
| 2 | Fri Nov 12 | vs Kent State | W73-59 | 2-0 | 1.000 | - | FS1 | Cintas Center · Cincinnati, OH |
| 3 | Thu Nov 18 | vs Ohio State | W71-65 | 3-0 | 1.000 | - | FS1 | Cintas Center · Cincinnati, OH |
| 4 | Sun Nov 21 | vs Norfolk St | W88-48 | 4-0 | 1.000 | - | FS1 | Cintas Center · Cincinnati, OH |
| 5 | Wed Nov 24 | at Iowa State | L70-82 | 4-1 | .800 | - | ESPNU | James H. Hilton Coliseum · Ames, IA |
| 6 | Fri Nov 26 | at Virginia Tech | W59-58 | 5-1 | .833 | - | ESPN2 | Cassell Coliseum · Blacksburg, VA |
| 7 | Wed Dec 1 | vs C Michigan | W78-45 | 6-1 | .857 | - | FS1 | Cintas Center · Cincinnati, OH |
| 8 | Sun Dec 5 | at Oklahoma St | W77-71 | 7-1 | .875 | - | ESPN2 | Gallagher-Iba Arena · Stillwater, OK |
| 9 | Wed Dec 8 | vs Ball State | W96-50 | 8-1 | .889 | - | FS1 | Cintas Center · Cincinnati, OH |
| 10 | Sat Dec 11 | vs Cincinnati | W83-63 | 9-1 | .900 | - | FS1 | Cintas Center · Cincinnati, OH |
| 11 | Wed Dec 15 | vs Morehead St | W86-63 | 10-1 | .909 | #22 | FS1 | Cintas Center · Cincinnati, OH |
| 12 | Sat Dec 18 | vs Marquette | W80-71 | 11-1 | .917 | #22 | FS1 | Cintas Center · Cincinnati, OH |
| 13 | Tue Dec 21 | at #23Villanova | L58-71 | 11-2 | .846 | #18 | FS1 | Finneran Pavilion · Villanova, PA |
| 14 | Tue Dec 28 | vs UConn | PPD | 23-13 | .639 | #23 | | Cintas Center · Cincinnati, OH |
| 16 | Fri Jan 7 | at Butler | W87-72 | 12-2 | .857 | #22 | | Hinkle Fieldhouse · Indianapolis, IN |
| 17 | Wed Jan 12 | vs#14Villanova | L60-64 | 12-3 | .800 | #17 | FS1 | Cintas Center · Cincinnati, OH |
| 18 | Sat Jan 15 | vs Creighton | W80-73 | 13-3 | .813 | #17 | FOX | Cintas Center · Cincinnati, OH |
| 19 | Wed Jan 19 | at DePaul | W68-67 | 14-3 | .824 | #20 | FS1 | Wintrust Arena · Chicago, IL |
| 20 | Sun Jan 23 | atMarquette | L64-75 | 14-4 | .778 | #20 | FS1 | Fiserv Forum · Milwaukee, WI |
| 21 | Wed Jan 26 | vs #17Providence | L62-65 | 14-5 | .737 | #21 | CBS | Cintas Center · Cincinnati, OH |
| 22 | Sat Jan 29 | atCreighton | W74-64 | 15-5 | .750 | #21 | FS1 | CHI Health Center Omaha · Omaha, NE |
| 23 | Wed Feb 2 | vsButler | W68-66 | 16-5 | .762 | #21 | CBS | Cintas Center · Cincinnati, OH |
| 24 | Sat Feb 5 | vsDePaul | L65-69 | 16-6 | .727 | #21 | FS1 | Cintas Center · Cincinnati, OH |
| 25 | Wed Feb 9 | at Seton Hall | L71-73 | 16-7 | .696 | #25 | FS1 | Prudential Center · Newark, NJ |
| 26 | Fri Feb 11 | vs#24UConn | W74-68 | 17-7 | .708 | #25 | FS1 | Cintas Center · Cincinnati, OH |
| 27 | Wed Feb 16 | vs St John's | L73-86 | 17-8 | .680 | - | CBS | Cintas Center · Cincinnati, OH |
| 28 | Sat Feb 19 | at#24UConn | L61-72 | 17-9 | .654 | - | FOX | Gampel Pavilion · Storrs, CT |
| 29 | Wed Feb 23 | at#11Providence | L92-99 (3OT) | 17-10 | .630 | - | CBS | Amica Mutual Pavilion · Providence, RI |
| 30 | Sat Feb 26 | vsSeton Hall | L66-82 | 17-11 | .607 | - | FOX | Cintas Center · Cincinnati, OH |
| 31 | Wed Mar 2 | atSt John's | L66-81 | 17-12 | .586 | - | FS1 | Carnesecca Arena · Queens, NY |
| 32 | Sat Mar 5 | vs Georgetown | W97-75 | 18-12 | .600 | - | FS1 | Cintas Center · Cincinnati, OH |
| 33 | Wed Mar 9 | vsButler | L82-89 (OT) | 18-13 | .581 | - | FS1 | Cintas Center · Cincinnati, OH |
| 34 | Tue Mar 15 | vs Cleveland St | W72-68 | 19-13 | .594 | - | ESPNU | Cintas Center · Cincinnati, OH |
| 35 | Sun Mar 20 | vs Florida | W72-56 | 20-13 | .606 | - | ESPN | Cintas Center · Cincinnati, OH |
| 36 | Tue Mar 22 | vs Vanderbilt | W75-73 | 21-13 | .618 | - | ESPN | Cintas Center · Cincinnati, OH |
| 37 | Tue Mar 29 | vs St Bonaventure | W84-77 | 22-13 | .629 | - | ESPN | Cintas Center · Cincinnati, OH |
| 38 | Thu Mar 31 | at Texas A&M | W73-72 | 23-13 | .639 | - | ESPN | Reed Arena · College Station, TX |
