| 1 | Tue Nov 5 | at SDSU | L42-77 | 0-1 | .000 | - | | Viejas Arena · San Diego, CA |
| 2 | Sat Nov 9 | atWichita St | L63-69 | 0-2 | .000 | - | | Charles Koch Arena · Wichita, KS |
| 3 | Fri Nov 15 | atSouth Dakota | L69-88 | 0-3 | .000 | - | | Sanford Coyote Sports Center · Vermillion, SD |
| 4 | Tue Nov 19 | atArkansas | L51-82 | 0-4 | .000 | - | | Bud Walton Arena · Fayetteville, AR |
| 5 | Sat Nov 23 | atN Kentucky | W98-96 (2OT) | 1-4 | .200 | - | | Truist Arena · Highland Heights, KY |
| 6 | Mon Nov 25 | atMontana | L62-74 | 1-5 | .167 | - | | Dahlberg Arena · Missoula, MT |
| 7 | Sat Nov 30 | vsLamar | W76-73 | 2-5 | .286 | - | | H&PE Arena · Houston, TX |
| 8 | Wed Dec 4 | at9Gonzaga | L62-101 | 2-6 | .250 | - | | McCarthey Athletic Center · Spokane, WA |
| 9 | Sat Dec 7 | vsTBD | W85-47 | 3-6 | .333 | - | | H&PE Arena · Houston, TX |
| 10 | Wed Dec 18 | atNevada | L73-91 | 3-7 | .300 | - | | Barclays Center · Brooklyn, NY |
| 11 | Sat Dec 21 | at8Oregon | L78-84 | 3-8 | .273 | - | PACN | Matthew Knight Arena · Eugene, OR |
| 12 | Sat Dec 28 | atArizona St | L81-98 | 3-9 | .250 | - | PACN | Desert Financial Arena · Tempe, AZ |
| 13 | Mon Dec 30 | atTexas A&M | L55-58 | 3-10 | .231 | - | | Reed Arena · College Station, TX |
| 14 | Sat Jan 4 | vsSouthern | W77-68 | 4-10 | .286 | - | | H&PE Arena · Houston, TX |
| 15 | Mon Jan 6 | vsAlcorn St | L80-95 | 4-11 | .267 | - | | H&PE Arena · Houston, TX |
| 16 | Sat Jan 11 | vsPrairie View | W71-67 | 5-11 | .313 | - | | H&PE Arena · Houston, TX |
| 17 | Sat Jan 18 | atJackson St | W77-66 | 6-11 | .353 | - | | Lee E. Williams Athletic and Assembly Center · Jackson, MS |
| 18 | Mon Jan 20 | atGrambling | W68-61 | 7-11 | .389 | - | | Fredrick C. Hobdy Assembly Center · Grambling, LA |
| 19 | Sat Jan 25 | vsMiss Valley St | W80-67 | 8-11 | .421 | - | | H&PE Arena · Houston, TX |
| 20 | Mon Jan 27 | vsAR-Pine Bluff | W68-57 | 9-11 | .450 | - | | H&PE Arena · Houston, TX |
| 21 | Sat Feb 1 | atAlabama A&M | W82-73 | 10-11 | .476 | - | | T.M. Elmore Gymnasium · Normal, AL |
| 22 | Mon Feb 3 | atAlabama St | L55-79 | 10-12 | .455 | - | | Dunn-Oliver Acadome · Montgomery, AL |
| 23 | Sat Feb 8 | atPrairie View | L59-69 | 10-13 | .435 | - | | William Nicks Building · Prairie View, TX |
| 24 | Sat Feb 15 | vsJackson St | W77-74 | 11-13 | .458 | - | | H&PE Arena · Houston, TX |
| 25 | Mon Feb 17 | vsGrambling | W93-79 | 12-13 | .480 | - | | H&PE Arena · Houston, TX |
| 26 | Sat Feb 22 | atMiss Valley St | W94-92 | 13-13 | .500 | - | | Robert W. Harrison HPER Complex · Itta Bena, MS |
| 27 | Mon Feb 24 | atAR-Pine Bluff | L72-74 (OT) | 13-14 | .481 | - | | H. O. Clemmons Arena · Pine Bluff, AR |
| 28 | Sat Feb 29 | vsAlabama A&M | W85-58 | 14-14 | .500 | - | | H&PE Arena · Houston, TX |
| 29 | Mon Mar 2 | vsAlabama St | W78-73 | 15-14 | .517 | - | ESPNU | H&PE Arena · Houston, TX |
| 30 | Thu Mar 5 | atSouthern | L74-89 | 15-15 | .500 | - | | F. G. Clark Activity Center · Baton Rouge, LA |
| 31 | Sat Mar 7 | atAlcorn St | L75-90 | 15-16 | .484 | - | | Davey L. Whitney Complex · Lorman, MS |
| 32 | Tue Mar 10 | vsGrambling | W75-62 | 16-16 | .500 | - | | H&PE Arena · Houston, TX |
